Blaschkoid blue vitiligo

GVMs will arise from mutations occurring early in development, whereas mild GVMs are due to mutations appearing later and/ or in areas of lower angiogenic activity. Because of the autosomal-dominant inheritance, our patient has a 50% chance of transmitting the mutation to his offspring, who can be severely affected depending on the temporal and spatial occurrence of the second-hit mutations. In conclusion, this case report contributes to document the involvement of the c.157_161del mutation, as well as supporting the somatic second-hit model for GVMs formation because of the high phenotypic variability in individuals who have the same inherited mutation in the same family.