In this paper, the missile database system for the multidisciplinary design and optimization framework has been designed and investigated. The requirements of the missiles database are analyzed and the database design concept has been defined first. The data flow among the analysis disciplines is investigated and the Entity-Relation diagram is constructed to develop the database table and to define the database schema. The developed database system is integrated into the missile design framework to perform the store, search and management of the design data during the design and analysis of the missile development, hence the efficiency and validity of the database designed in this study has been demonstrated.