Identification of latent membrane protein 2A (LMP2A) specific targets for treatment and eradication of Epstein-Barr virus (EBV)-associated diseases.
暂无分享,去创建一个
[1] T. Portis,et al. Epstein-Barr Virus LMP2A Interferes with Global Transcription Factor Regulation When Expressed during B-Lymphocyte Development , 2003, Journal of Virology.
[2] R. Longnecker,et al. Inhibition of host kinase activity altered by the LMP2A signalosome-a therapeutic target for Epstein-Barr virus latency and associated disease. , 2002, Antiviral research.
[3] S. Hamilton-Dutoit,et al. Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma , 2002, Oncogene.
[4] H. Stein,et al. Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. , 2002, Blood.
[5] H. Stein,et al. Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease. , 2002, Blood.
[6] P. Farmer,et al. The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1 , 2002, British Journal of Cancer.
[7] J. Stein,et al. Piceatannol, a natural analog of resveratrol, inhibits progression through the S phase of the cell cycle in colorectal cancer cell lines. , 2002, The Journal of nutrition.
[8] H. Stein,et al. Activated Notch 1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma , 2002 .
[9] R. Longnecker,et al. LMP2A survival and developmental signals are transmitted through Btk-dependent and Btk-independent pathways. , 2001, Virology.
[10] D. Thorley-Lawson,et al. Epstein-Barr virus: exploiting the immune system , 2001, Nature Reviews Immunology.
[11] R. Longnecker,et al. Epstein-Barr Virus Latent Membrane Protein 2a (Lmp2a) Employs the Slp-65 Signaling Module , 2001, The Journal of experimental medicine.
[12] R. Longnecker,et al. PY Motifs of Epstein-Barr Virus LMP2A Regulate Protein Stability and Phosphorylation of LMP2A-Associated Proteins , 2001, Journal of Virology.
[13] J. Karp,et al. Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial. , 2001, Blood.
[14] R. Longnecker,et al. Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR. , 2001, Immunity.
[15] R. Longnecker,et al. The LMP2A ITAM Is Essential for Providing B Cells with Development and Survival Signals In Vivo , 2000, Journal of Virology.
[16] R. N. Harty,et al. WW- and SH3-domain interactions with Epstein-Barr virus LMP2A. , 2000, Experimental cell research.
[17] R. Longnecker,et al. The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases. , 2000, Virology.
[18] R. Longnecker,et al. Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence? , 2000, Advances in cancer research.
[19] L. Staudt,et al. Reed-Sternberg cell genome expression supports a B-cell lineage. , 1999, Blood.
[20] E. Kremmer,et al. Tyrosine 112 of Latent Membrane Protein 2A Is Essential for Protein Tyrosine Kinase Loading and Regulation of Epstein-Barr Virus Latency , 1998, Journal of Virology.
[21] S. Anderson,et al. Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals. , 1998, Immunity.
[22] K. Rajewsky,et al. In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death , 1997, Cell.
[23] R. Longnecker,et al. The immunoreceptor tyrosine-based activation motif of Epstein-Barr virus LMP2A is essential for blocking BCR-mediated signal transduction. , 1997, Virology.
[24] E. Kieff. Epstein-Barr virus and its replication , 1996 .
[25] G. Niedobitek. The role of Epstein-Barr virus in the pathogenesis of Hodgkin's disease. , 1996, Annals of oncology : official journal of the European Society for Medical Oncology.
[26] E. Kieff,et al. Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. , 1995, Immunity.
[27] E. Kieff,et al. Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes , 1993, Journal of virology.
[28] E. Kieff,et al. An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases , 1992, Journal of virology.
[29] T. Ooka. The molecular biology of Epstein-Barr virus. , 1985, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.