Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies
暂无分享,去创建一个
Michael J. Osborn | A. Boudreau | N. Trinklein | M. Brüggemann | I. Anegon | Duy Pham | R. Buelow | U. Schellenberger | S. Clarke | K. Dang | Katherine E. Harris | B. Jorgensen | P. Pratap | H. Ugamraj | S. Force Aldred | B. Ma | A. Balasubramani | Laura M. Davison | P. Sankaran | L. Ouisse | H. Ogana | W. van Schooten
[1] Michael J. Osborn,et al. Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies , 2018, Front. Immunol..
[2] W. Richards,et al. A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity , 2018, The Journal of Biological Chemistry.
[3] Conor McMahon,et al. Yeast surface display platform for rapid discovery of conformationally selective nanobodies , 2018, Nature Structural & Molecular Biology.
[4] Kevin A. Henry,et al. Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human VH/VL Single-Domain Antibodies from In Vitro Display Libraries , 2017, Front. Immunol..
[5] Harald Kolmar,et al. Camelid and shark single domain antibodies: structural features and therapeutic potential. , 2017, Current opinion in structural biology.
[6] Anke Wienecke-Baldacchino,et al. Functionally Convergent B Cell Receptor Sequences in Transgenic Rats Expressing a Human B Cell Repertoire in Response to Tetanus Toxoid and Measles Antigens , 2017, bioRxiv.
[7] F. Tian,et al. Humanized CD7 nanobody-based immunotoxins exhibit promising anti-T-cell acute lymphoblastic leukemia potential , 2017, International journal of nanomedicine.
[8] J. Nilvebrant,et al. Engineered Autonomous Human Variable Domains. , 2017, Current pharmaceutical design.
[9] N. Trinklein,et al. A Single Human Papillomavirus Vaccine Dose Improves B Cell Memory in Previously Infected Subjects , 2016, EBioMedicine.
[10] C. Chung,et al. Novel Interaction Mechanism of a Domain Antibody-based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency than Ranibizumab and Bevacizumab and Improved Capacity over Aflibercept* , 2016, The Journal of Biological Chemistry.
[11] C. Palomo,et al. Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection , 2015, Antimicrobial Agents and Chemotherapy.
[12] D. Christ,et al. Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies* , 2015, The Journal of Biological Chemistry.
[13] Steven Lantz,et al. Examination of thermal unfolding and aggregation profiles of a series of developable therapeutic monoclonal antibodies. , 2015, Molecular pharmaceutics.
[14] C. Barelle,et al. Shark variable new antigen receptor biologics – a novel technology platform for therapeutic drug development , 2014, Expert opinion on biological therapy.
[15] D. Christ,et al. Stability engineering of the human antibody repertoire , 2014, FEBS letters.
[16] N. Harris,et al. The heavy chain diseases: clinical and pathologic features. , 2014, Oncology.
[17] Michael J. Osborn,et al. Human antibody expression in transgenic rats: comparison of chimeric IgH loci with human VH, D and JH but bearing different rat C-gene regions. , 2013, Journal of immunological methods.
[18] Xinglong Wang,et al. Design and Selection of a Camelid Single-Chain Antibody Yeast Two-Hybrid Library Produced De Novo for the Cap Protein of Porcine Circovirus Type 2 (PCV2) , 2013, PloS one.
[19] Michael J. Osborn,et al. High-Affinity IgG Antibodies Develop Naturally in Ig-Knockout Rats Carrying Germline Human IgH/Igκ/Igλ Loci Bearing the Rat CH Region , 2013, The Journal of Immunology.
[20] Ming Lei,et al. Frontier of therapeutic antibody discovery: The challenges and how to face them. , 2012, World journal of biological chemistry.
[21] J. Lebbink,et al. Heavy chain-only antibodies and tetravalent bispecific antibody neutralizing Staphylococcus aureus leukotoxins , 2011, Proceedings of the National Academy of Sciences.
[22] Nick Deschacht,et al. A Case Of Convergence: Why Did a Simple Alternative to Canonical Antibodies Arise in Sharks and Camels? , 2011, PLoS biology.
[23] A. Marco. Biotechnological applications of recombinant single-domain antibody fragments , 2011 .
[24] A. de Marco. Biotechnological applications of recombinant single-domain antibody fragments , 2011, Microbial cell factories.
[25] N. Pannu,et al. REFMAC5 for the refinement of macromolecular crystal structures , 2011, Acta crystallographica. Section D, Biological crystallography.
[26] M. Son,et al. Preparing DNA libraries for multiplexed paired-end deep sequencing for Illumina GA sequencers. , 2011, Current protocols in microbiology.
[27] Kai Lou. Crescendo's TKO , 2010 .
[28] Michael J. Osborn,et al. Characterization of immunoglobulin heavy chain knockout rats , 2010, European journal of immunology.
[29] C. Plummer,et al. Next generation immunotherapeutics--honing the magic bullet. , 2009, Current opinion in biotechnology.
[30] Ignacio Anegon,et al. Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases , 2009, Science.
[31] M. Seman,et al. Single domain antibodies: promising experimental and therapeutic tools in infection and immunity , 2009, Medical Microbiology and Immunology.
[32] Etienne Weiss,et al. Therapeutic antibodies: successes, limitations and hopes for the future , 2009, British journal of pharmacology.
[33] S. Muyldermans,et al. General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold* , 2009, Journal of Biological Chemistry.
[34] C. J. Bond,et al. Comprehensive Analysis of the Factors Contributing to the Stability and Solubility of Autonomous Human VH Domains* , 2008, Journal of Biological Chemistry.
[35] Michael J. Osborn,et al. Heavy chain–only antibodies are spontaneously produced in light chain–deficient mice , 2007, The Journal of experimental medicine.
[36] Rodrigo Lopez,et al. Clustal W and Clustal X version 2.0 , 2007, Bioinform..
[37] Randy J. Read,et al. Phaser crystallographic software , 2007, Journal of applied crystallography.
[38] F. Grosveld,et al. Generation of heavy-chain-only antibodies in mice , 2006, Proceedings of the National Academy of Sciences.
[39] David Jung,et al. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. , 2006, Annual review of immunology.
[40] P. Hudson,et al. Engineered antibody fragments and the rise of single domains , 2005, Nature Biotechnology.
[41] L. Wyns,et al. Antigen binding and solubility effects upon the veneering of a camel VHH in framework-2 to mimic a VH. , 2005, Journal of molecular biology.
[42] Marie-Paule Lefranc,et al. IMGT , the international ImMunoGeneTics information system , 2003 .
[43] Kevin Cowtan,et al. research papers Acta Crystallographica Section D Biological , 2005 .
[44] Ron D. Appel,et al. ExPASy: the proteomics server for in-depth protein knowledge and analysis , 2003, Nucleic Acids Res..
[45] Andreas Plückthun,et al. Biophysical properties of human antibody variable domains. , 2003, Journal of molecular biology.
[46] I. Lundkvist,et al. Long‐term kinetics of adult human antibody repertoires , 2002, Immunology.
[47] L. Wyns,et al. Camel Single-domain Antibodies as Modular Building Units in Bispecific and Bivalent Antibody Constructs* , 2001, The Journal of Biological Chemistry.
[48] O. Britanova,et al. Amplification of cDNA ends based on template-switching effect and step-out PCR. , 1999, Nucleic acids research.
[49] Lode Wyns,et al. Potent enzyme inhibitors derived from dromedary heavy‐chain antibodies , 1998, The EMBO journal.
[50] R. Brezinschek,et al. Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells. , 1997, The Journal of clinical investigation.
[51] L. Riechmann,et al. Single antibody domains as small recognition units: design and in vitro antigen selection of camelized, human VH domains with improved protein stability. , 1996, Protein engineering.
[52] Austin Hughes,et al. A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks , 1995, Nature.
[53] L. Riechmann,et al. ‘Camelising’ human antibody fragments: NMR studies on VH domains , 1994, FEBS letters.
[54] S. Muyldermans,et al. Naturally occurring antibodies devoid of light chains , 1993, Nature.
[55] D. Eisenberg,et al. Analysis of membrane and surface protein sequences with the hydrophobic moment plot. , 1984, Journal of molecular biology.
[56] R. Doolittle,et al. A simple method for displaying the hydropathic character of a protein. , 1982, Journal of molecular biology.
[57] E. Kabat,et al. Sequences of proteins of immunological interest , 1991 .