Influence of temperature on the precision of noninvasive glucose sensing by near-infrared spectroscopy

The use of near-infrared spectroscopy for the monitoring of blood glucose concentration is limited by many ambiguous factors, which leads to the prediction precision is not satisfied. Due to the weak interested signal and the difficulty to quantify the physiological noise directly, the absorbance induced by glucose concentration and temperature was analyzed based on Beer-Lambert Law and displacement between glucose and water. Then the transmittance of glucose aqueous solution in different temperatures was measured by spectrometer to investigate the influence of glucose concentration and temperature. As it's difficult to distinguish the influence of temperature from the diffuse reflectance, the Monte Carlo simulation was used to compute the light intensity induced by the change in glucose concentration and physiological temperature. Finally, the influence of actual physiological temperature on the prediction model of glucose concentration was estimated based on the oral glucose tolerance tests of two diabetics. The result showed that, near the normal physiological temperature, the intensity of diffuse reflectance caused by -0.1 °C change in temperature was equivalent to that caused by 2.7 mmol/L change in glucose concentration. Moreover, the proportion of prediction error induced by temperature to the total error was more than 50%.

[1]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[2]  Kexin Xu,et al.  Non-invasive glucose sensing with near-infrared spectroscopy enhanced by optical measurement conditions reproduction technique , 2005 .

[3]  L Wang,et al.  MCML--Monte Carlo modeling of light transport in multi-layered tissues. , 1995, Computer methods and programs in biomedicine.

[4]  S. Thennadil,et al.  Optical properties of human skin in the near infrared wavelength range of 1000 to 2200 nm. , 2001, Journal of biomedical optics.

[5]  R. C. Weast.  CRC Handbook of Chemistry and Physics , 1973 .

[6]  O. Khalil,et al.  Non-invasive glucose measurement technologies: an update from 1999 to the dawn of the new millennium. , 2004, Diabetes technology & therapeutics.

[7]  Y. Ozaki,et al.  In Vivo Noninvasive Measurement of Blood Glucose by Near-Infrared Diffuse-Reflectance Spectroscopy , 2003, Applied spectroscopy.

[8]  S. Venyaminov,et al.  Water (H2O and D2O) molar absorptivity in the 1000-4000 cm-1 range and quantitative infrared spectroscopy of aqueous solutions. , 1997, Analytical biochemistry.

[9]  Yukio Yamada,et al.  Simulation study of in vitro glucose measurement by NIR spectroscopy and a method of error reduction. , 2003, Physics in medicine and biology.

[11]  G. W. Small,et al.  Noninvasive glucose sensing. , 2005, Analytical chemistry.

[12]  Kevin H. Hazen,et al.  Measurement of Glucose in Water with First-Overtone Near-Infrared Spectra , 1998 .

[13]  Michael S. Feld,et al.  Noninvasive Glucose Sensing with Raman Spectroscopy , 2009 .

[14]  S. V. Selishchev,et al.  Noninvasive methods for blood glucose measurement , 2007, Meditsinskaia tekhnika.

[15]  Kexin Xu,et al.  Study on optical measurement conditions for noninvasive blood glucose sensing , 2004, SPIE BiOS.

[16]  Stefan Andersson-Engels,et al.  Influence of Temperature on Water and Aqueous Glucose Absorption Spectra in the Near- and Mid-Infrared Regions at Physiologically Relevant Temperatures , 2003, Applied spectroscopy.

[17]  T. B. Blank,et al.  Noninvasive prediction of glucose by near-infrared diffuse reflectance spectroscopy. , 1999, Clinical chemistry.