In vivo measurement of the human epidermal thickness in different localizations by multiphoton laser tomography

Background: The in vivo measurement of epidermal thickness is still challenging. While ultrasound, optical coherence tomography and confocal laser microscopy are used with moderate success, this issue has not been addressed by multiphoton laser tomography.

[1]  H. Wulf,et al.  Epidermal thickness at different body sites: relationship to age, gender, pigmentation, blood content, skin type and smoking habits. , 2003, Acta dermato-venereologica.

[2]  G F Gerberick,et al.  Cumulative effects from repeated exposures to suberythemal doses of UVB and UVA in human skin. , 1995, Journal of the American Academy of Dermatology.

[3]  A. Ormerod,et al.  Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double‐blind trial , 2005, The British journal of dermatology.

[4]  Gregor B.E. Jemec,et al.  Morphology and Epidermal Thickness of Normal Skin Imaged by Optical Coherence Tomography , 2008, Dermatology.

[5]  Karsten König,et al.  Morphological skin ageing criteria by multiphoton laser scanning tomography: non‐invasive in vivo scoring of the dermal fibre network , 2008, Experimental dermatology.

[6]  J T Whitton,et al.  The thickness of the epidermis , 1973, The British journal of dermatology.

[7]  K. Sellheyer Pathogenesis of solar elastosis: synthesis or degradation? , 2003, Journal of cutaneous pathology.

[8]  K. König,et al.  Multiphoton tissue imaging using high‐NA microendoscopes and flexible scan heads for clinical studies and small animal research , 2008, Journal of biophotonics.

[9]  J. Uitto,et al.  Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin , 2002, Experimental dermatology.

[10]  Roland Bazin,et al.  Influence of age on the wrinkling capacities of skin , 2002, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[11]  J. Welzel,et al.  Evaluation of the atrophogenic potential of different glucocorticoids using optical coherence tomography, 20‐MHz ultrasound and profilometry; a double‐blind, placebo‐controlled trial , 2006, The British journal of dermatology.

[12]  Karsten König,et al.  Clinical multiphoton tomography , 2008, Journal of biophotonics.

[13]  P. Corcuff,et al.  Morphometry of human epidermis in vivo by real-time confocal microscopy , 2004, Archives of Dermatological Research.

[14]  P Altmeyer,et al.  UVA1 and UVB irradiated skin investigated by optical coherence tomography in vivo: a preliminary study , 2005, Clinical and experimental dermatology.

[15]  M. Ichihashi,et al.  Epidermal changes caused by chronic low-dose UV irradiation induce wrinkle formation in hairless mouse. , 2001, Journal of dermatological science.

[16]  H. Wulf,et al.  Photoprotection due to pigmentation and epidermal thickness after repeated exposure to ultraviolet light and psoralen plus ultraviolet A therapy , 1995, Photodermatology, photoimmunology & photomedicine.

[17]  M Rajadhyaksha,et al.  Topographic variations in normal skin, as viewed by in vivo reflectance confocal microscopy. , 2001, The Journal of investigative dermatology.

[18]  T. Desai,et al.  The Use of High‐Frequency Ultrasound in the Evaluation of Superficial and Nodular Basal Cell Carcinomas , 2007, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[19]  Karsten König,et al.  In vivo assessment of human skin aging by multiphoton laser scanning tomography. , 2006, Optics letters.

[20]  P. Bastien,et al.  In vivo epidermal thickness measurement: ultrasound vs. confocal imaging , 2004, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[21]  T. Gambichler,et al.  Epidermal thickness assessed by optical coherence tomography and routine histology: preliminary results of method comparison , 2006, Journal of the European Academy of Dermatology and Venereology : JEADV.

[22]  A D Pearse,et al.  Epidermal changes in human skin following irradiation with either UVB or UVA. , 1987, The Journal of investigative dermatology.