A lymphoma patient with Cytomegalovirus retinitis and post‐autologous hematopoietic cell transplantation immune reconstitution uveitis: A case report and review of the literature

Cytomegalovirus (CMV) retinitis in hematologic malignancies in the absence of hematopoietic cell transplant (HCT) is uncommon. We report a case of a 54‐year‐old woman with peripheral T‐cell lymphoma who develops CMV retinitis and subsequently undergoes an autologous HCT, with eventual development of immune reconstitution uveitis. We further reviewed the PubMed literature on CMV retinitis in patients with lymphoma. We describe that CMV retinitis in patients with lymphoma has variable clinical presentations, may occur at any time during the course of the disease and chemotherapy, and is associated with significant morbidity.

[1]  F. Ensoli,et al.  Cytomegalovirus infection in hematologic malignancy settings other than the allogeneic transplant , 2018, Hematological oncology.

[2]  H. Iwasaki,et al.  Cytomegalovirus retinitis in relapsed or refractory low-grade B cell lymphoma patients treated with bendamustine , 2017, Annals of Hematology.

[3]  C. Merle,et al.  Cytomegalovirus Infection With Retinitis After Brentuximab Vedotin Treatment for CD30+ Lymphoma , 2017, Open forum infectious diseases.

[4]  S. Teoh,et al.  Immune recovery uveitis in HIV patients with cytomegalovirus retinitis in the era of HAART therapy—a 5-year study from Singapore , 2016, Journal of Ophthalmic Inflammation and Infection.

[5]  K. Grønbæk,et al.  Lenalidomide-bendamustine-rituximab in patients older than 65 years with untreated mantle cell lymphoma. , 2016, Blood.

[6]  Tarek Alasil,et al.  Delayed bilateral fibrinous anterior chamber reaction following autologous bone marrow transplant and cataract surgery , 2016, American journal of ophthalmology case reports.

[7]  J. Carbone The Immunology of Posttransplant CMV Infection: Potential Effect of CMV Immunoglobulins on Distinct Components of the Immune Response to CMV , 2016, Transplantation.

[8]  A. Mathai,et al.  Atypical cytomegalovirus retinitis in non-Hodgkin's lymphoma , 2015, BMJ Case Reports.

[9]  A. Bakunowicz-Łazarczyk,et al.  Immune Recovery Uveitis: Pathogenesis, Clinical Symptoms, and Treatment , 2014, Mediators of inflammation.

[10]  S. Lim,et al.  Cytomegalovirus infection and end-organ disease in Asian patients with lymphoma receiving chemotherapy , 2014, Leukemia & lymphoma.

[11]  J. Dvořák,et al.  A possible coincidence of cytomegalovirus retinitis and intraocular lymphoma in a patient with systemic non-Hodgkin’s lymphoma , 2013, Virology Journal.

[12]  J. Farmer,et al.  Cytomegalovirus retinitis mimicking intraocular lymphoma , 2008, Clinical ophthalmology.

[13]  A. Younes,et al.  Cytomegalovirus infection in patients with lymphoma: an important cause of morbidity and mortality. , 2006, Clinical lymphoma & myeloma.

[14]  B. Vote,et al.  Recurrent cytomegalovirus retinitis in a patient with a normal lymphocyte count who had undergone splenectomy for lymphoma. , 2005, Retina.

[15]  R. Chawla,et al.  Cytomegalovirus Retinitis in a Patient with Non-Hodgkin's Lymphoma: A Diagnostic Dilemma , 2005, European journal of ophthalmology.

[16]  J. Kempen,et al.  Clinical characteristics and outcomes of cytomegalovirus retinitis in persons without human immunodeficiency virus infection. , 2004, American journal of ophthalmology.

[17]  M. Boeckh,et al.  Virological, clinical, and ophthalmologic features of cytomegalovirus retinitis after hematopoietic stem cell transplantation. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[18]  Dubus,et al.  Variation in the histological pattern of nodal involvement by gamma/delta T‐cell lymphoma , 2000, Histopathology.

[19]  T. Yamauchi,et al.  Successful treatment of cytomegalovirus retinitis in a patient with malignant lymphoma: a case report and review of the literature. , 1999, International journal of hematology.

[20]  D. Rubinstein,et al.  Immune reconstitution and immunotherapy after autologous hematopoietic stem cell transplantation. , 1998, Blood.

[21]  N. Berinstein,et al.  Cytomegalovirus retinitis and low‐grade non‐Hodgkin's lymphoma: Case report and review of the literature , 1998, American journal of hematology.

[22]  P. Ljungman,et al.  Cytomegalovirus excretion as a predictor of cytomegalovirus disease after marrow transplantation: importance of cytomegalovirus viremia. , 1990, The Journal of infectious diseases.

[23]  J. Toy,et al.  Cytomegalovirus retinitis misdiagnosed as Hodgkin's lymphoma deposits. , 1978, British medical journal.

[24]  M. Mura,et al.  Intravitreal ganciclovir in the management of non-AIDS-related human cytomegalovirus retinitis. , 2010, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.

[25]  R. Bouabdallah,et al.  Cytomegalovirus retinitis revealing a leukemic gamma/delta T-cell lymphoma. , 1999, Haematologica.

[26]  A. Caliendo,et al.  Bilateral acute retinal necrosis caused by cytomegalovirus in an immunocompromised patient. , 1999, American journal of ophthalmology.

[27]  G. Jaffe CYTOMEGALOVIRUS RETINITIS ASSOCIATED WITH HODGKIN'S DISEASE , 1996, Retina.