Regional haemodynamic effects of human α‐ and β‐calcitonin gene‐related peptide in conscious Wistar rats

1 A comparative study was carried out to assess the regional haemodynamic effects of intravenous infusion of human α‐ and β‐calcitonin gene‐related peptide (CGRP; 0.006, 0.06 and 0.6 nmol h−1) in conscious, unrestrained Wistar rats. 2 With human α‐CGRP, tachycardia was always accompanied by a fall in mean arterial blood pressure (MBP), but human β‐CGRP at the middle dose caused tachycardia with no significant hypotension. 3 Human α‐ and β‐CGRP both caused dose‐dependent falls in MBP accompanied by common carotid and hindquarters vasodilatations and increased flows. The highest dose of α‐ and β‐CGRP caused mesenteric vasoconstriction and renal vasodilatation, but the latter was not associated with an increase in flow. 4 With the intermediate dose, human α‐CGRP caused more significant haemodynamic changes than did human β‐CGRP. In addition, comparison with previous experiments involving infusion of rat α‐CGRP indicated that human α‐CGRP had more potent haemodynamic effects than the former.

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