Should linking replace regression when mapping from profile-based measures to preference-based measures?

BACKGROUND Profile instruments are frequently used to assess health-related quality of life and other patient-reported outcomes. However, preference-based measures are required for health-economic cost-utility evaluations. RESULTS Although regression-based approaches are commonly used to map from profile measures to preference measures, we show that this results in biased estimates because of regression to the mean. CONCLUSIONS Linking (scale-aligning) is proposed as an alternative.

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