Photodynamic therapy with cationic photosensitizers

We characterized sites of photodamage catalyzed by two cationic photosensitizers tetrabromo- rhodamine 123 (TBR), which is recognized by the multidrug transporter, and a monocationic porphyrin (MCP), which is not. The transporter is an outward transport system associated with examples of drug resistance. Irradiation of multidrug-resistant cells treated with TBR resulted in highly selective photodamage to the transporter site, while MCP catalyzed non- specific membrane damage to cells regardless of transporter expression.

[1]  Johnson Rk,et al.  In vivo characteristics of resistance and cross-resistance of an adriamycin-resistant subline of P388 leukemia. , 1978 .

[2]  S. Selman,et al.  IMINIUM SALT OF COPPER BENZOCHLORIN (CDS1), A NOVEL PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY: MECHANISM OF CELL KILLING , 1993, Photochemistry and photobiology.

[3]  A. Oseroff,et al.  Intramitochondrial dyes allow selective in vitro photolysis of carcinoma cells. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[4]  David Kessel,et al.  IMPAIRED ACCUMULATION OF A CATIONIC PHOTOSENSITIZING AGENT BY A CELL LINE EXHIBITING MULTIDRUG RESISTANCE , 1994, Photochemistry and photobiology.

[5]  Kevin M. Smith,et al.  PHOTOSENSITIZATION WITH BACTERIOCHLORINS , 1993, Photochemistry and photobiology.

[6]  C J Gomer,et al.  Metabolic properties and photosensitizing responsiveness of mono-L-aspartyl chlorin e6 in a mouse tumor model. , 1992, Cancer research.

[7]  K. Berg,et al.  THE PHOTODEGRADATION OF PORPHYRINS IN CELLS CAN BE USED TO ESTIMATE THE LIFETIME OF SINGLET OXYGEN , 1991, Photochemistry and photobiology.

[8]  D. Kessel,et al.  Exploring multidrug resistance using rhodamine 123. , 1989, Cancer communications.

[9]  D. Kessel,et al.  Correlations between anthracycline resistance, drug accumulation and membrane glycoprotein patterns in solid tumors of mice. , 1985, Cancer letters.

[10]  D Kukuruga,et al.  Characterization of multidrug resistance by fluorescent dyes. , 1991, Cancer research.

[11]  I. Pastan,et al.  Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells. , 1990, The Journal of biological chemistry.

[12]  Julia G. Levy,et al.  Characterization Of Benzoporphyrin Derivative, A New Photosensitizer , 1989, Other Conferences.

[13]  David Kessel,et al.  Characterization of photodynamic and sonodynamic cytotoxicity by fluorescent probes , 1993, Photonics West - Lasers and Applications in Science and Engineering.

[14]  T. Dougherty,et al.  HOW DOES PHOTODYNAMIC THERAPY WORK? , 1992, Photochemistry and photobiology.

[15]  T. Hasan,et al.  Rhodamine dyes as potential agents for photochemotherapy of cancer in human bladder carcinoma cells. , 1989, Cancer research.

[16]  J Moan,et al.  PHOTOCHEMOTHERAPY OF CANCER: EXPERIMENTAL RESEARCH , 1992, Photochemistry and photobiology.

[17]  M. Inaba.  Uptake and retention of adriamycin and daunorubicin by sensitive and anthracycline-resistant subline of P388 leukemia. , 1978 .

[18]  I. Pastan,et al.  Biochemistry of multidrug resistance mediated by the multidrug transporter. , 1993, Annual review of biochemistry.

[19]  C. Schanbacher,et al.  Photosensitization, uptake, and retention of phenoxazine Nile blue derivatives in human bladder carcinoma cells. , 1991, Cancer research.