Hyaluronic Acid Encapsulated CuS Gel-Mediated Near-Infrared Laser-Induced Controllable Transdermal Drug Delivery for Sustained Therapy

Efficient transdermal drug delivery to the circulatory system of body has great benefit compared to traditional needle injection and oral administration approach due to avoiding the emotional trauma and pain for the patients. Disrupting the stratum corneum (SC) is crucial for successful transdermal drug delivery, and thermal ablation is emerging as the advanced strategy for it. Herein, hyaluronic acid (HA) encapsulated CuS (HA-CuS) nanoparticles with excellent biocompatibility and remarkable photothermal translation efficacy were synthesized for transdermal drug delivery. The transdermal cargo delivery capability of the proposed HA-CuS gel was comprehensively investigated. Simply controlling the NIR laser irradiation power or time enabled controllable translocation of the model biomacromolecule of bovine serum albumin (BSA) into skin in vivo. Furthermore, the feasibility of the HA-CuS-mediated transdermal insulin delivery for type 1 diabetes therapy of nude mice was investigated. It presented sustained an...

[1]  Chen-zhong Li,et al.  Tunable synthesis solid or hollow Au–Ag nanostructure, assembled with GO and comparative study of their catalytic properties , 2016 .

[2]  Dan Dan Zhu,et al.  Rapidly separating microneedles for transdermal drug delivery. , 2016, Acta biomaterialia.

[3]  Bo-Yang Yu,et al.  Pegylated folate and peptide-decorated graphene oxide nanovehicle for in vivo targeted delivery of anticancer drugs and therapeutic self-monitoring. , 2016, Biosensors & bioelectronics.

[4]  Z. Dai,et al.  Preparation of Silicon-Carbon-Based Dots@Dopamine and Its Application in Intracellular Ag(+) Detection and Cell Imaging. , 2016, ACS applied materials & interfaces.

[5]  D. Frenkel,et al.  Insulin-coated gold nanoparticles as a new concept for personalized and adjustable glucose regulation. , 2015, Nanoscale.

[6]  Qijin Wan,et al.  Lithium-doped NiO nanofibers for non-enzymatic glucose sensing , 2015 .

[7]  Haeshin Lee,et al.  Functionalized biocompatible WO3 nanoparticles for triggered and targeted in vitro and in vivo photothermal therapy. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[8]  Chen-Sheng Yeh,et al.  Rattle‐Type Fe3O4@CuS Developed to Conduct Magnetically Guided Photoinduced Hyperthermia at First and Second NIR Biological Windows , 2015 .

[9]  Hongmei Qin,et al.  Direct Fabrication of the Graphene-Based Composite for Cancer Phototherapy through Graphite Exfoliation with a Photosensitizer. , 2015, ACS applied materials & interfaces.

[10]  Yu Cao,et al.  Tunable Fabrication of Molybdenum Disulfide Quantum Dots for Intracellular MicroRNA Detection and Multiphoton Bioimaging. , 2015, Small.

[11]  Chunshui Yu,et al.  BSA-directed synthesis of CuS nanoparticles as a biocompatible photothermal agent for tumor ablation in vivo. , 2015, Dalton transactions.

[12]  Zhen Gu,et al.  Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery , 2015, Proceedings of the National Academy of Sciences.

[13]  Meifang Zhu,et al.  In vitro and in vivo toxicity studies of copper sulfide nanoplates for potential photothermal applications. , 2015, Nanomedicine : nanotechnology, biology, and medicine.

[14]  K. Vávrová,et al.  Interactions of hyaluronic Acid with the skin and implications for the dermal delivery of biomacromolecules. , 2015, Molecular pharmaceutics.

[15]  Y. Liu,et al.  Reversibly extracellular pH controlled cellular uptake and photothermal therapy by PEGylated mixed-charge gold nanostars. , 2015, Small.

[16]  J. du Plessis,et al.  Breaching the skin barrier through temperature modulations. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[17]  Mei Yang,et al.  Biodegradation of carbon nanohorns in macrophage cells. , 2015, Nanoscale.

[18]  Xiaolan Chen,et al.  Copper sulfide nanoparticles with phospholipid-PEG coating for in vivo near-infrared photothermal cancer therapy. , 2015, Chemistry, an Asian journal.

[19]  Penghui Zhang,et al.  In situ amplification of intracellular microRNA with MNAzyme nanodevices for multiplexed imaging, logic operation, and controlled drug release. , 2015, ACS nano.

[20]  Zhen Gu,et al.  Emerging micro- and nanotechnology based synthetic approaches for insulin delivery. , 2014, Chemical Society reviews.

[21]  T. Niidome,et al.  CW/pulsed NIR irradiation of gold nanorods: effect on transdermal protein delivery mediated by photothermal ablation. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[22]  Xiaogang Qu,et al.  Hydrophobic Anticancer Drug Delivery by a 980 nm Laser‐Driven Photothermal Vehicle for Efficient Synergistic Therapy of Cancer Cells In Vivo , 2013, Advanced materials.

[23]  Ajazuddin,et al.  Approaches for breaking the barriers of drug permeation through transdermal drug delivery. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[24]  Wei Lu,et al.  Hollow copper sulfide nanoparticle-mediated transdermal drug delivery. , 2012, Small.

[25]  M. Goto,et al.  Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice. , 2012, Nanoscale.

[26]  Jung-Hwan Park,et al.  Microsecond thermal ablation of skin for transdermal drug delivery. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[27]  Y. Kalia,et al.  Effect of controlled laser microporation on drug transport kinetics into and across the skin. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[28]  Robert Langer,et al.  Transdermal drug delivery , 2008, Nature Biotechnology.

[29]  M. Kinoshita,et al.  Hyaluronic acid: separation and biological implications. , 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[30]  J. Bos,et al.  The 500 Dalton rule for the skin penetration of chemical compounds and drugs , 2000, Experimental dermatology.