InfoHub: an Alternative Approach to Process Visualization

Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis are depicted in formulas (1), (2) and (3): (1) (2) (3) wherein: A is -C 3BOND C-, trans -HC=CH-, -CH2CH2- or -CH=CHCH2-; X is lower alkoxy, hydroxy, or (2,2,2)-trifluoroethoxy; Y is hydrogen, exo-(lower alkyl) or endo-(lower alkyl); is an integer of 2-4; R1 is -CH2OH, -CHO, -CO2R or -CO2H, and the olefin formed by the R1(CH2)nCH= moiety is either (E) or (Z); R2 is hydrogen or methyl, or optionally -CH=CH2 when A is -CH=CHCH2-; and R3 is linear or branched alkyl, alkenyl or alkynyl having 5-10 carbon atoms, +TR -(CH2)m-phenyl or CH2O-phenyl; in which each phenyl may be optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen; in which: a is an integer of 0, 1 or 2; b is an integer of 3-7; m is an integer of 0, 1 or 2; and R is wherein x is +TR in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.