Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans
暂无分享,去创建一个
Nicola K. Wilson | B. Göttgens | N. Wilson | S. Miyano | Y. Shiraishi | S. Ogawa | K. Matsuo | P. Monks | Y. Okuno | Kenichi Yoshida | K. J. Patel | E. Ito | S. Kojima | M. Takata | H. Muramatsu | Lucas B. Pontel | Rui Yu | R. Cordell | Masayuki Kobayashi | Frédéric Langevin | H. Yabe | M. Yabe | T. Moriguchi | T. Osumi | S. Watcham | Felix A. Dingler | M. Hodskinson | Asuka Hira | Anfeng Mu | Christopher L. Millington | Minako Mori | Nina Oberbeck | Ashley N. Kamimae-Lanning | Meng Wang | Yusuke Okamoto | M. Kato | Camille Nadler | Motohiro Kato
[1] J. Chin,et al. Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms , 2020, Nature.
[2] J. Niu,et al. ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA enriched extracellular vesicles. , 2019, Journal of hepatology.
[3] F. Hamey,et al. Machine learning predicts putative hematopoietic stem cells within large single-cell transcriptomics data sets , 2019, Experimental hematology.
[4] Sergey O. Sulima,et al. Hallmarks of ribosomopathies , 2019, Nucleic acids research.
[5] A. Shimamura,et al. Genetic predisposition to MDS: clinical features and clonal evolution. , 2019, Blood.
[6] Ryan L. Collins,et al. The mutational constraint spectrum quantified from variation in 141,456 humans , 2020, Nature.
[7] M. Stratton,et al. The mutational landscape of normal human endometrial epithelium , 2018, bioRxiv.
[8] M. Stratton,et al. The landscape of somatic mutation in normal colorectal epithelial cells , 2018, Nature.
[9] Peter J. Campbell,et al. Population dynamics of normal human blood inferred from somatic mutations , 2018, Nature.
[10] Samuel L. Wolock,et al. A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice. , 2018, Blood.
[11] Ville Mustonen,et al. The repertoire of mutational signatures in human cancer , 2018, Nature.
[12] J. Soulier,et al. A landscape of germ line mutations in a cohort of inherited bone marrow failure patients. , 2018, Blood.
[13] Fabian J Theis,et al. SCANPY: large-scale single-cell gene expression data analysis , 2018, Genome Biology.
[14] M. Stratton,et al. Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells , 2018, Nature.
[15] Christopher J. Chang,et al. Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism , 2017, Nature.
[16] Ruedi Aebersold,et al. A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability , 2017, Cell.
[17] S. Miyano,et al. Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes , 2017, Genetics in Medicine.
[18] Hans Clevers,et al. Tissue-specific mutation accumulation in human adult stem cells during life , 2016, Nature.
[19] A. D’Andrea,et al. The Fanconi anaemia pathway: new players and new functions , 2016, Nature Reviews Molecular Cell Biology.
[20] K. Rudolph,et al. Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing , 2016, Nature Cell Biology.
[21] Gad Getz,et al. Somatic ERCC2 Mutations Are Associated with a Distinct Genomic Signature in Urothelial Tumors , 2016, Nature Genetics.
[22] Charles H. Yoon,et al. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq , 2016, Science.
[23] J. Walter,et al. What is the DNA repair defect underlying Fanconi anemia? , 2015, Current opinion in cell biology.
[24] M. Stratton,et al. Clock-like mutational processes in human somatic cells , 2015, Nature Genetics.
[25] K. J. Patel,et al. Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen , 2015, Molecular cell.
[26] Melanie Doyle-Eisele,et al. Formation, Accumulation, and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage. , 2015, Toxicological sciences : an official journal of the Society of Toxicology.
[27] David A. Williams,et al. Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells , 2015, Nature.
[28] Julio C. B. Ferreira,et al. A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant. , 2015, Annual review of pharmacology and toxicology.
[29] S. Miyano,et al. Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients. , 2013, Blood.
[30] Mauricio O. Carneiro,et al. From FastQ Data to High‐Confidence Variant Calls: The Genome Analysis Toolkit Best Practices Pipeline , 2013, Current protocols in bioinformatics.
[31] F. Wright,et al. Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following [13C2]-acetaldehyde exposure. , 2013, Toxicological sciences : an official journal of the Society of Toxicology.
[32] Molly C. Kottemann,et al. Fanconi anaemia and the repair of Watson and Crick DNA crosslinks , 2013, Nature.
[33] K. J. Patel,et al. Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function , 2012, Nature.
[34] K. J. Patel,et al. Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway , 2011, Nature Structural &Molecular Biology.
[35] K. J. Patel,et al. Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice , 2011, Nature.
[36] C. C. Garcia,et al. [13C2]-Acetaldehyde promotes unequivocal formation of 1,N2-propano-2'-deoxyguanosine in human cells. , 2011, Journal of the American Chemical Society.
[37] Brian C. Jackson,et al. Update on the aldehyde dehydrogenase gene (ALDH) superfamily , 2011, Human Genomics.
[38] J. McDonald,et al. Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposure. , 2011, Chemical research in toxicology.
[39] B. Ebert,et al. Ribosomopathies: human disorders of ribosome dysfunction. , 2010, Blood.
[40] S. Franco,et al. Differential Requirement for H2AX and 53BP1 in Organismal Development and Genome Maintenance in the Absence of Poly(ADP)ribosyl Polymerase 1 , 2010, Molecular and Cellular Biology.
[41] Patricia A Stewart,et al. Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries: the National Cancer Institute Cohort. , 2009, Journal of the National Cancer Institute.
[42] David Goldman,et al. The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption , 2009, PLoS medicine.
[43] 邓伟平,et al. Dyskeratosis congenita , 2007 .
[44] Stephen D Dertinger,et al. In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity. , 2007, Mutation research.
[45] S. Kato,et al. In Vitro Effect of Fludarabine, Cyclophosphamide, and Cytosine Arabinoside on Chromosome Breakage in Fanconi Anemia Patients: Relevance to Stem Cell Transplantation , 2007, International journal of hematology.
[46] K. Kidd,et al. The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination , 2004, Annals of human genetics.
[47] H. E. Marshall,et al. Essential Roles of S-Nitrosothiols in Vascular Homeostasis and Endotoxic Shock , 2004, Cell.
[48] F. Ventura,et al. Determination of aldehydes in drinking water using pentafluorobenzylhydroxylamine derivatization and solid-phase microextraction. , 2002, Journal of chromatography. A.
[49] T Takezaki,et al. Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer. , 2001, Carcinogenesis.
[50] Yuan Zhang,et al. Determination of formaldehyde in blood plasma by high-performance liquid chromatography with fluorescence detection. , 2001, Journal of chromatography. B, Biomedical sciences and applications.
[51] T. Omori,et al. Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics. , 2001, Carcinogenesis.
[52] Yuko Yamaguchi-Iwai,et al. Sister Chromatid Exchanges Are Mediated by Homologous Recombination in Vertebrate Cells , 1999, Molecular and Cellular Biology.
[53] J. Pawliszyn,et al. Sampling and determination of formaldehyde using solid-phase microextraction with on-fiber derivatization. , 1998, Analytical chemistry.
[54] A. Chatterjee,et al. Modulation of mitomycin C-induced sister chromatid exchanges and cell cycle delay by buthionine sulfoximine and reduced glutathione in mouse bone marrow cells in vivo. , 1998, Mutation research.
[55] H. Morreau,et al. Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence , 1997, Current Biology.
[56] D. Agarwal,et al. Aldehyde Dehydrogenase Deficiency as Cause of Facial Flushing Reaction to Alcohol in Japanese , 1995, Alcohol health and research world.
[57] M. Koivusalo,et al. Formaldehyde dehydrogenase from human liver. Purification, properties, and evidence for the formation of glutathione thiol esters by the enzyme. , 1974, The Journal of biological chemistry.
[58] J. German,et al. A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. , 1974, Proceedings of the National Academy of Sciences of the United States of America.
[59] C. Bernofsky,et al. Mitochondrial acetaldehyde dehydrogenase from Saccharomyces cerevisiae. , 1974, Biochimica et biophysica acta.
[60] M. Sasaki,et al. A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents. , 1973, Cancer research.
[61] Sharon A Savage,et al. Dyskeratosis congenita. , 2009, Hematology/oncology clinics of North America.
[62] Susan E. Luczak,et al. ALDH2, ADH1B, and ADH1C Genotypes in Asians: A Literature Review , 2007, Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism.
[63] K. Matsuo,et al. Gene-environment Interactions and Polymorphism Studies of Cancer Risk in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center II (HERPACC-II). , 2001, Asian Pacific journal of cancer prevention : APJCP.
[64] H J Edenberg,et al. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. , 1989, The Journal of clinical investigation.
[65] H. Heck,et al. Formaldehyde (CH2O) concentrations in the blood of humans and Fischer-344 rats exposed to CH2O under controlled conditions. , 1985, American Industrial Hygiene Association journal.