Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans

[1]  J. Chin,et al.  Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms , 2020, Nature.

[2]  J. Niu,et al.  ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA enriched extracellular vesicles. , 2019, Journal of hepatology.

[3]  F. Hamey,et al.  Machine learning predicts putative hematopoietic stem cells within large single-cell transcriptomics data sets , 2019, Experimental hematology.

[4]  Sergey O. Sulima,et al.  Hallmarks of ribosomopathies , 2019, Nucleic acids research.

[5]  A. Shimamura,et al.  Genetic predisposition to MDS: clinical features and clonal evolution. , 2019, Blood.

[6]  Ryan L. Collins,et al.  The mutational constraint spectrum quantified from variation in 141,456 humans , 2020, Nature.

[7]  M. Stratton,et al.  Abstract IA007: The mutational landscape of normal human endometrial epithelium , 2021, Functional Genomics and Proteomics.

[8]  M. Stratton,et al.  The landscape of somatic mutation in normal colorectal epithelial cells , 2018, Nature.

[9]  Peter J. Campbell,et al.  Population dynamics of normal human blood inferred from somatic mutations , 2018, Nature.

[10]  Samuel L. Wolock,et al.  A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice. , 2018, Blood.

[11]  Ville Mustonen,et al.  The repertoire of mutational signatures in human cancer , 2018, Nature.

[12]  J. Soulier,et al.  A landscape of germ line mutations in a cohort of inherited bone marrow failure patients. , 2018, Blood.

[13]  Fabian J Theis,et al.  SCANPY: large-scale single-cell gene expression data analysis , 2018, Genome Biology.

[14]  M. Stratton,et al.  Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells , 2018, Nature.

[15]  Christopher J. Chang,et al.  Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism , 2017, Nature.

[16]  Ruedi Aebersold,et al.  A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability , 2017, Cell.

[17]  S. Miyano,et al.  Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes , 2017, Genetics in Medicine.

[18]  Hans Clevers,et al.  Tissue-specific mutation accumulation in human adult stem cells during life , 2016, Nature.

[19]  A. D’Andrea,et al.  The Fanconi anaemia pathway: new players and new functions , 2016, Nature Reviews Molecular Cell Biology.

[20]  K. Rudolph,et al.  Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing , 2016, Nature Cell Biology.

[21]  Gad Getz,et al.  Somatic ERCC2 Mutations Are Associated with a Distinct Genomic Signature in Urothelial Tumors , 2016, Nature Genetics.

[22]  Charles H. Yoon,et al.  Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq , 2016, Science.

[23]  J. Walter,et al.  What is the DNA repair defect underlying Fanconi anemia? , 2015, Current opinion in cell biology.

[24]  M. Stratton,et al.  Clock-like mutational processes in human somatic cells , 2015, Nature Genetics.

[25]  K. J. Patel,et al.  Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen , 2015, Molecular cell.

[26]  Melanie Doyle-Eisele,et al.  Formation, Accumulation, and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage. , 2015, Toxicological sciences : an official journal of the Society of Toxicology.

[27]  David A. Williams,et al.  Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells , 2015, Nature.

[28]  Julio C. B. Ferreira,et al.  A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant. , 2015, Annual review of pharmacology and toxicology.

[29]  S. Miyano,et al.  Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients. , 2013, Blood.

[30]  Mauricio O. Carneiro,et al.  From FastQ Data to High‐Confidence Variant Calls: The Genome Analysis Toolkit Best Practices Pipeline , 2013, Current protocols in bioinformatics.

[31]  F. Wright,et al.  Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following [13C2]-acetaldehyde exposure. , 2013, Toxicological sciences : an official journal of the Society of Toxicology.

[32]  Molly C. Kottemann,et al.  Fanconi anaemia and the repair of Watson and Crick DNA crosslinks , 2013, Nature.

[33]  K. J. Patel,et al.  Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function , 2012, Nature.

[34]  K. J. Patel,et al.  Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway , 2011, Nature Structural &Molecular Biology.

[35]  K. J. Patel,et al.  Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice , 2011, Nature.

[36]  C. C. Garcia,et al.  [13C2]-Acetaldehyde promotes unequivocal formation of 1,N2-propano-2'-deoxyguanosine in human cells. , 2011, Journal of the American Chemical Society.

[37]  Brian C. Jackson,et al.  Update on the aldehyde dehydrogenase gene (ALDH) superfamily , 2011, Human Genomics.

[38]  J. McDonald,et al.  Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposure. , 2011, Chemical research in toxicology.

[39]  B. Ebert,et al.  Ribosomopathies: human disorders of ribosome dysfunction. , 2010, Blood.

[40]  S. Franco,et al.  Differential Requirement for H2AX and 53BP1 in Organismal Development and Genome Maintenance in the Absence of Poly(ADP)ribosyl Polymerase 1 , 2010, Molecular and Cellular Biology.

[41]  Patricia A Stewart,et al.  Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries: the National Cancer Institute Cohort. , 2009, Journal of the National Cancer Institute.

[42]  David Goldman,et al.  The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption , 2009, PLoS medicine.

[43]  邓伟平,et al.  Dyskeratosis congenita , 2007 .

[44]  Stephen D Dertinger,et al.  In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity. , 2007, Mutation research.

[45]  S. Kato,et al.  In Vitro Effect of Fludarabine, Cyclophosphamide, and Cytosine Arabinoside on Chromosome Breakage in Fanconi Anemia Patients: Relevance to Stem Cell Transplantation , 2007, International journal of hematology.

[46]  K. Kidd,et al.  The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination , 2004, Annals of human genetics.

[47]  H. E. Marshall,et al.  Essential Roles of S-Nitrosothiols in Vascular Homeostasis and Endotoxic Shock , 2004, Cell.

[48]  F. Ventura,et al.  Determination of aldehydes in drinking water using pentafluorobenzylhydroxylamine derivatization and solid-phase microextraction. , 2002, Journal of chromatography. A.

[49]  T Takezaki,et al.  Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer. , 2001, Carcinogenesis.

[50]  Yuan Zhang,et al.  Determination of formaldehyde in blood plasma by high-performance liquid chromatography with fluorescence detection. , 2001, Journal of chromatography. B, Biomedical sciences and applications.

[51]  T. Omori,et al.  Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics. , 2001, Carcinogenesis.

[52]  Yuko Yamaguchi-Iwai,et al.  Sister Chromatid Exchanges Are Mediated by Homologous Recombination in Vertebrate Cells , 1999, Molecular and Cellular Biology.

[53]  J. Pawliszyn,et al.  Sampling and determination of formaldehyde using solid-phase microextraction with on-fiber derivatization. , 1998, Analytical chemistry.

[54]  A. Chatterjee,et al.  Modulation of mitomycin C-induced sister chromatid exchanges and cell cycle delay by buthionine sulfoximine and reduced glutathione in mouse bone marrow cells in vivo. , 1998, Mutation research.

[55]  H. Morreau,et al.  Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence , 1997, Current Biology.

[56]  D. Agarwal,et al.  ALDEHYDE DEHYDROGENASE DEFICIENCY AS CAUSE OF FACIAL FLUSHING REACTION TO ALCOHOL IN JAPANESE , 1981, The Lancet.

[57]  M. Koivusalo,et al.  Formaldehyde dehydrogenase from human liver. Purification, properties, and evidence for the formation of glutathione thiol esters by the enzyme. , 1974, The Journal of biological chemistry.

[58]  J. German,et al.  A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[59]  C. Bernofsky,et al.  Mitochondrial acetaldehyde dehydrogenase from Saccharomyces cerevisiae. , 1974, Biochimica et biophysica acta.

[60]  M. Sasaki,et al.  A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents. , 1973, Cancer research.

[61]  Sharon A Savage,et al.  Dyskeratosis congenita. , 2009, Hematology/oncology clinics of North America.

[62]  Susan E. Luczak,et al.  ALDH2, ADH1B, and ADH1C Genotypes in Asians: A Literature Review , 2007, Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism.

[63]  K. Matsuo,et al.  Gene-environment Interactions and Polymorphism Studies of Cancer Risk in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center II (HERPACC-II). , 2001, Asian Pacific journal of cancer prevention : APJCP.

[64]  H J Edenberg,et al.  Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. , 1989, The Journal of clinical investigation.

[65]  H. Heck,et al.  Formaldehyde (CH2O) concentrations in the blood of humans and Fischer-344 rats exposed to CH2O under controlled conditions. , 1985, American Industrial Hygiene Association journal.