Target Prediction Algorithms and Bioinformatics Resources for miRNA Studies

The recent publication of the Chinese hamster ovary (CHO) genome has heralded the beginning of an exciting new era of research in this industrially important cell line. Advances in our understanding of CHO at the molecular level have the potential to facilitate the development of modified cell lines and biomarkers to increase the efficiency of recombinant protein production processes. In recent years there has been growing interest in the function of small non-coding RNA molecules, known as microRNAs (miRNAs), as targets to enable multigene CHO cell engineering. To date, miRNAs have been shown to be dysregulated in a number of processes including cell growth and apoptosis.

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