EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly

[1]  J. Yue,et al.  The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle , 2022, Cell Death & Differentiation.

[2]  Christopher J. Obara,et al.  ER proteins decipher the tubulin code to regulate organelle distribution , 2021, Nature.

[3]  R. Hegde,et al.  The architecture of EMC reveals a path for membrane protein insertion , 2020, bioRxiv.

[4]  Billy Tsai,et al.  Selective EMC subunits act as molecular tethers of intracellular organelles exploited during viral entry , 2020, Nature Communications.

[5]  Takunori Satoh,et al.  ER membrane protein complex is required for the insertions of late-synthesized transmembrane helices of Rh1 in Drosophila photoreceptors , 2019, Molecular Biology of the Cell.

[6]  H. Rothan,et al.  Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes , 2019, Pathogens.

[7]  Xianjun Zhu,et al.  ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice , 2019, Cell Death & Differentiation.

[8]  Billy Tsai,et al.  The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection , 2019, Cell reports.

[9]  R. Hegde,et al.  The Role of EMC during Membrane Protein Biogenesis. , 2019, Trends in cell biology.

[10]  J. Smyth,et al.  A novel, dynein-independent mechanism focuses the endoplasmic reticulum around spindle poles in dividing Drosophila spermatocytes , 2019, Scientific Reports.

[11]  Matthias J. Feige,et al.  A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration , 2019, Nature Communications.

[12]  R. Hegde,et al.  The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis , 2019, Journal of Cell Science.

[13]  Martin Eisenacher,et al.  The PRIDE database and related tools and resources in 2019: improving support for quantification data , 2018, Nucleic Acids Res..

[14]  R. Hegde,et al.  EMC Is Required to Initiate Accurate Membrane Protein Topogenesis , 2018, Cell.

[15]  Jeffrey A. Hussmann,et al.  The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins , 2018, eLife.

[16]  J. Whitsett,et al.  EMC3 coordinates surfactant protein and lipid homeostasis required for respiration , 2017, The Journal of clinical investigation.

[17]  T. Rapoport,et al.  Toward an understanding of the Cdc48/p97 ATPase , 2017, F1000Research.

[18]  Devin P. Sullivan,et al.  A subcellular map of the human proteome , 2017, Science.

[19]  L. Pelletier,et al.  Mitotic spindle assembly in animal cells: a fine balancing act , 2017, Nature Reviews Molecular Cell Biology.

[20]  Billy Tsai,et al.  EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus , 2016, eLife.

[21]  Lauren M. Zasadil,et al.  Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression. , 2016, Developmental cell.

[22]  Jeremy G. Wideman.  The ubiquitous and ancient ER membrane protein complex (EMC): tether or not? , 2015, F1000Research.

[23]  Takunori Satoh,et al.  dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors , 2015, eLife.

[24]  M. Greenblatt,et al.  Spindle Microtubule Dysfunction and Cancer Predisposition , 2014, Journal of cellular physiology.

[25]  Barry P. Young,et al.  A Conserved Endoplasmic Reticulum Membrane Protein Complex (EMC) Facilitates Phospholipid Transfer from the ER to Mitochondria , 2014, PLoS biology.

[26]  Samuel Wagner,et al.  Pre- and post-processing workflow for affinity purification mass spectrometry data. , 2014, Journal of proteome research.

[27]  P. Thurner,et al.  Sox17 is required for normal pulmonary vascular morphogenesis. , 2014, Developmental biology.

[28]  P. Meraldi,et al.  The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A , 2013, The Journal of cell biology.

[29]  Roland L. Dunbrack,et al.  Aurora A kinase (AURKA) in normal and pathological cell division , 2013, Cellular and Molecular Life Sciences.

[30]  K. Fukasawa,et al.  Nucleophosmin/B23 activates Aurora A at the centrosome through phosphorylation of serine 89 , 2012, The Journal of cell biology.

[31]  J. Wade Harper,et al.  Defining human ERAD networks through an integrative mapping strategy , 2011, Nature Cell Biology.

[32]  L. Galluzzi,et al.  Mitotic catastrophe: a mechanism for avoiding genomic instability , 2011, Nature Reviews Molecular Cell Biology.

[33]  M. Selbach,et al.  Global quantification of mammalian gene expression control , 2011, Nature.

[34]  D. Gerlich,et al.  Cdc48/p97–Ufd1–Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells , 2011, Journal of Cell Science.

[35]  P. Stukenberg,et al.  Spindle Poisons and Cell Fate : A Tale of Two Pathways , 2011 .

[36]  D. Livingston,et al.  Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation , 2010, Proceedings of the National Academy of Sciences.

[37]  R. Durbin,et al.  Systematic Analysis of Human Protein Complexes Identifies Chromosome Segregation Proteins , 2010, Science.

[38]  J. Taylor,et al.  VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD , 2010, Autophagy.

[39]  P. Young,et al.  A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. , 2009, Journal of molecular biology.

[40]  Jing Chen,et al.  ToppGene Suite for gene list enrichment analysis and candidate gene prioritization , 2009, Nucleic Acids Res..

[41]  S. Collins,et al.  Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum , 2009, Science.

[42]  M. Mann,et al.  MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification , 2008, Nature Biotechnology.

[43]  J. Pines,et al.  APC/CCdh1 Targets Aurora Kinase to Control Reorganization of the Mitotic Spindle at Anaphase , 2008, Current Biology.

[44]  J. Schumacher,et al.  An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2. , 2008, Developmental cell.

[45]  I. Vernos,et al.  Dissecting the role of Aurora A during spindle assembly , 2008, The EMBO journal.

[46]  R. Heald,et al.  Mechanisms of mitotic spindle assembly and function. , 2008, International review of cytology.

[47]  M. Gotta,et al.  Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin , 2007, Nature.

[48]  Merja Joensuu,et al.  Endoplasmic reticulum remains continuous and undergoes sheet-to-tubule transformation during cell division in mammalian cells , 2007, The Journal of cell biology.

[49]  F. Gergely,et al.  Aurora-A: the maker and breaker of spindle poles , 2007, Journal of Cell Science.

[50]  A. Chakravarty,et al.  MLN8054, a Small-Molecule Inhibitor of Aurora A, Causes Spindle Pole and Chromosome Congression Defects Leading to Aneuploidy , 2007, Molecular and Cellular Biology.

[51]  Qing Jiang,et al.  Roles of Aurora Kinases in Mitosis and Tumorigenesis , 2007, Molecular Cancer Research.

[52]  Tomoki Nakamura,et al.  Neural Crest Cells Retain Multipotential Characteristics in the Developing Valves and Label the Cardiac Conduction System , 2006, Circulation research.

[53]  Hui Yang,et al.  Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase , 2005, FEBS letters.

[54]  Michael R. Taylor,et al.  The Zebrafish pob Gene Encodes a Novel Protein Required for Survival of Red Cone Photoreceptor Cells Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under accession no. AY745978. , 2005, Genetics.

[55]  G. Hannon,et al.  Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[56]  Hiroshi Katayama,et al.  The Aurora kinases: Role in cell transformation and tumorigenesis , 2003, Cancer and Metastasis Reviews.

[57]  E. Nigg,et al.  Proteome analysis of the human mitotic spindle , 2004 .

[58]  Yixian Zheng,et al.  The AAA-ATPase Cdc48/p97 Regulates Spindle Disassembly at the End of Mitosis , 2003, Cell.

[59]  H. Saya,et al.  Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells , 2003, Cell.

[60]  E. Olson,et al.  Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth , 2003, Development.

[61]  H. Saya,et al.  Roles of aurora‐A kinase in mitotic entry and G2 checkpoint in mammalian cells , 2002, Genes to cells : devoted to molecular & cellular mechanisms.

[62]  K. Ohashi,et al.  Mitosis-specific Activation of LIM Motif-containing Protein Kinase and Roles of Cofilin Phosphorylation and Dephosphorylation in Mitosis* , 2002, The Journal of Biological Chemistry.

[63]  Michael J. Lee,et al.  Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules , 2002, The Journal of cell biology.

[64]  J. Partanen,et al.  The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics. , 2002, Molecular biology of the cell.

[65]  K. Kinzler,et al.  Genetic instabilities in human cancers , 1998, Nature.

[66]  M. Dorée,et al.  The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly. , 1998, Journal of cell science.

[67]  W. Scott,et al.  Potentiation of acetazolamide induced ectrodactyly in SWV and C57BL/6J mice by cadmium sulfate. , 1984, Teratology.