The sheep as a model for osteoporosis in humans.

There is great interest in large animal models for studying different aspects of osteoporosis. Several laboratories around the world have used ovariectomized sheep as a model because of their ease of housing and handling, low expense compared to other large animals, availability and acceptance in society as a research animal. They have been used to study the response to new therapies for post-menopausal osteoporosis, low-magnitude mechanical stimulation, orthopedic implants in osteoporotic bone and bioactive ceramics to strengthen vertebral bodies. To produce severely osteopenic bone comparable to that seen in humans, a combination of estrogen deficiency following ovariectomy plus a calcium-wasting diet is currently being investigated.

[1]  S. Robins.  Biomarkers of Disease: Biochemical markers of bone resorption , 2002 .

[2]  M. Petri,et al.  Percutaneous vertebroplasty treatment of steroid-induced osteoporotic compression fractures. , 1998, Arthritis and rheumatism.

[3]  J. Barr,et al.  Percutaneous Vertebroplasty for Pain Relief and Spinal Stabilization , 2000, Spine.

[4]  A. Turner,et al.  Changes in bone mineral density and bone-specific alkaline phosphatase in ovariectomized ewes. , 1995, Bone.

[5]  P. Delmas,et al.  Dose effects on ewe bone remodeling of short-term sodium fluoride administration--a histomorphometric and biochemical study. , 1991, Bone.

[6]  James Hartke,et al.  Preclinical Development of Agents for the Treatment of Osteoporosis , 1999, Toxicologic pathology.

[7]  R. Assaker,et al.  Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up. , 1996, Radiology.

[8]  M. Holick,et al.  Elderly women in northern New England exhibit seasonal changes in bone mineral density and calciotropic hormones. , 1994, Bone and mineral.

[9]  J. Wark,et al.  Hormonal regulation of osteocalcin plasma production and clearance in sheep. , 1989, Endocrinology.

[10]  Grier Sj,et al.  The Use of Dual-Energy X-ray Absorptiometry in Animals , 1996 .

[11]  E. Block,et al.  Effects of manipulating dietary cation-anion balance on macromineral balance in sheep. , 1991, Journal of dairy science.

[12]  S. Belkoff,et al.  Temperature elevation caused by bone cement polymerization during vertebroplasty. , 1999, Bone.

[13]  D. Mitton,et al.  Comparison between bone density and bone strength in glucocorticoid-treated aged ewes. , 1995, Bone.

[14]  A L Boskey,et al.  Musculoskeletal disorders and orthopedic conditions. , 2001, JAMA.

[15]  小野卓史.  歯科と医科の接点 睡眠とこう合-閉塞型睡眠時無呼吸症候群- , 2003 .

[16]  D. Kalu.  The ovariectomized rat model of postmenopausal bone loss. , 1991, Bone and mineral.

[17]  E. Block,et al.  Effects of reducing dietary cation-anion balance on calcium kinetics in sheep. , 1991, Journal of dairy science.

[18]  E L Smith,et al.  Dose-response relationship between physical loading and mechanical competence of bone. , 1996, Bone.

[19]  J. D. Neill,et al.  The Physiology of reproduction , 1988 .

[20]  A. Cigada,et al.  In vitro and in vivo behaviour of Ca- and P-enriched anodized titanium. , 1999, Biomaterials.

[21]  R. Turner,et al.  The effects of fluoride on bone and implant histomorphometry in growing rats , 1989, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[22]  H. Paul,et al.  Effects of estrogen deficiency on the growth of tissue into porous titanium implants. , 1988, Journal of Bone and Joint Surgery. American volume.

[23]  E. Block,et al.  Effects of various dietary cation-anion balances on response to experimentally induced hypocalcemia in sheep. , 1991, Journal of dairy science.

[24]  G. Van der Perre,et al.  Effect of Salmon Calcitonin on Femoral Bone Quality in Adult Ovariectomized Ewes , 1996, Calcified Tissue International.

[25]  M. Lamghari,et al.  A model for evaluating injectable bone replacements in the vertebrae of sheep: radiological and histological study. , 1999, Biomaterials.

[26]  R. B. Johnson,et al.  Alveolar bone loss one year following ovariectomy in sheep. , 1997, Journal of periodontology.

[27]  G. Mcclearn,et al.  Selection of an appropriate animal model to study aging processes with special emphasis on the use of rat strains. , 1992, Journal of gerontology.

[28]  J. Wark,et al.  The potential of sheep for the study of osteopenia: current status and comparison with other animal models. , 1995, Bone.

[29]  P. Chavassieux,et al.  Bone effects of fluoride in animal models in vivo. A review and a recent study , 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[30]  J. Spence,et al.  Mandibular bone in ageing sheep. , 1982, Journal of comparative pathology.

[31]  S. Belkoff,et al.  An in vitro biomechanical evaluation of bone cements used in percutaneous vertebroplasty. , 1999, Bone.

[32]  M. Edgerton,et al.  Mandibular bone density in the ovariectomized ewe , 1996 .

[33]  C. Mallinckrodt,et al.  Dual-energy X-ray absorptiometry in sheep: experiences with in vivo and ex vivo studies. , 1995, Bone.

[34]  E. Barengolts,et al.  Effects of endurance exercise on bone mass and mechanical properties in intact and ovariectomized rats , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.