Bone adaptation to cyclic loading in murine caudal vertebrae is maintained with age and directly correlated to the local micromechanical environment.

[1]  C. Hernandez,et al.  The effects of misalignment during in vivo loading of bone: techniques to detect the proximity of objects in three-dimensional models. , 2014, Journal of biomechanics.

[2]  W. B. Edwards,et al.  In vivo loading model to examine bone adaptation in humans: A pilot study , 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[3]  Georg N Duda,et al.  Diminished response to in vivo mechanical loading in trabecular and not cortical bone in adulthood of female C57Bl/6 mice coincides with a reduction in deformation to load. , 2013, Bone.

[4]  Ralph Müller,et al.  Trabecular bone adapts to long-term cyclic loading by increasing stiffness and normalization of dynamic morphometric rates. , 2013, Bone.

[5]  Ralph Müller,et al.  Local Mechanical Stimuli Regulate Bone Formation and Resorption in Mice at the Tissue Level , 2013, PloS one.

[6]  R Müller,et al.  Longitudinal in vivo imaging of bone formation and resorption using fluorescence molecular tomography. , 2013, Bone.

[7]  R. Müller,et al.  ESTIMATION OF PHYSIOLOGICAL LOAD ON THE MOUSE TAIL VERTEBRA , 2012 .

[8]  S. Bain,et al.  Bone mechanotransduction may require augmentation in order to strengthen the senescent skeleton , 2012, Ageing Research Reviews.

[9]  Matthew J. Silva,et al.  Tibial Loading Increases Osteogenic Gene Expression and Cortical Bone Volume in Mature and Middle-Aged Mice , 2012, PloS one.

[10]  William J Browne,et al.  Bones' Adaptive Response to Mechanical Loading Is Essentially Linear Between the Low Strains Associated With Disuse and the High Strains Associated With the Lamellar/Woven Bone Transition , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[11]  R. Müller,et al.  Bone morphology allows estimation of loading history in a murine model of bone adaptation , 2012, Biomechanics and modeling in mechanobiology.

[12]  Craig R. Slyfield,et al.  Three‐dimensional dynamic bone histomorphometry , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[13]  Ralph Müller,et al.  Mouse tail vertebrae adapt to cyclic mechanical loading by increasing bone formation rate and decreasing bone resorption rate as shown by time-lapsed in vivo imaging of dynamic bone morphometry. , 2011, Bone.

[14]  Timothy M Wright,et al.  Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging. , 2011, Bone.

[15]  Matthew J. Silva,et al.  Low‐magnitude whole‐body vibration does not enhance the anabolic skeletal effects of intermittent PTH in adult mice , 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[16]  Ralph Müller,et al.  In vivo micro-computed tomography allows direct three-dimensional quantification of both bone formation and bone resorption parameters using time-lapsed imaging. , 2011, Bone.

[17]  Jack C. Yu,et al.  Effect of whole-body vibration on bone properties in aging mice. , 2010, Bone.

[18]  Matthew J. Silva,et al.  Age-Related Changes in Bone Structure and Strength in Female and Male BALB/c Mice , 2010, Calcified Tissue International.

[19]  T. Wilsgaard,et al.  Leisure time physical activity in adulthood is positively associated with bone mineral density 22 years later. The Tromsø study , 2010, European Journal of Epidemiology.

[20]  Matthew J Silva,et al.  Aged Mice Have Enhanced Endocortical Response and Normal Periosteal Response Compared With Young-Adult Mice Following 1 Week of Axial Tibial Compression , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[21]  Matthew J Silva,et al.  Skeletal effects of whole‐body vibration in adult and aged mice , 2010, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[22]  Matthew J. Silva,et al.  Constrained tibial vibration does not produce an anabolic bone response in adult mice. , 2009, Bone.

[23]  Xu Yang,et al.  The Effects of Loading on Cancellous Bone in the Rabbit , 2009, Clinical orthopaedics and related research.

[24]  Lance E. Lanyon,et al.  The mouse fibula as a suitable bone for the study of functional adaptation to mechanical loading , 2009, Bone.

[25]  Steven K Boyd,et al.  Postpubertal Architectural Developmental Patterns Differ Between the L3 Vertebra and Proximal Tibia in Three Inbred Strains of Mice , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[26]  Ralph Müller,et al.  A novel in vivo mouse model for mechanically stimulated bone adaptation – a combined experimental and computational validation study , 2008, Computer methods in biomechanics and biomedical engineering.

[27]  T. Skerry,et al.  The response of bone to mechanical loading and disuse: fundamental principles and influences on osteoblast/osteocyte homeostasis. , 2008, Archives of biochemistry and biophysics.

[28]  Ralph Müller,et al.  A scalable multi‐level preconditioner for matrix‐free µ‐finite element analysis of human bone structures , 2008 .

[29]  Mary L Bouxsein,et al.  Age‐Related Changes in Trabecular Architecture Differ in Female and Male C57BL/6J Mice , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[30]  T. Skerry,et al.  One mechanostat or many? Modifications of the site-specific response of bone to mechanical loading by nature and nurture. , 2006, Journal of musculoskeletal & neuronal interactions.

[31]  R. Müller,et al.  Compartmental Bone Morphometry in the Mouse Femur: Reproducibility and Resolution Dependence of Microtomographic Measurements , 2005, Calcified Tissue International.

[32]  T. Wright,et al.  Loading induces site-specific increases in mineral content assessed by microcomputed tomography of the mouse tibia. , 2005, Bone.

[33]  A. Robling,et al.  Mechanosensitivity of the rat skeleton decreases after a long period of loading, but is improved with time off. , 2005, Bone.

[34]  Matthew J. Silva,et al.  Experimental and finite element analysis of the rat ulnar loading model-correlations between strain and bone formation following fatigue loading. , 2004, Journal of biomechanics.

[35]  J. M. Somerville,et al.  Growth of C57Bl/6 Mice and the Material and Mechanical Properties of Cortical Bone from the Tibia , 2004, Calcified Tissue International.

[36]  Sundar Srinivasan,et al.  Enabling bone formation in the aged skeleton via rest-inserted mechanical loading. , 2003, Bone.

[37]  X. Guo,et al.  Trabecular Bone Response to Mechanical and Parathyroid Hormone Stimulation: The Role of Mechanical Microenvironment , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[38]  Sharmila Majumdar,et al.  Changes in Bone Structure and Mass With Advancing Age in the Male C57BL/6J Mouse , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[39]  Sundar Srinivasan,et al.  Noninvasive Loading of the Murine Tibia: An In Vivo Model for the Study of Mechanotransduction , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[40]  R. Zernicke,et al.  Strain Gradients Correlate with Sites of Exercise‐Induced Bone‐Forming Surfaces in the Adult Skeleton , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[41]  C. Rubin,et al.  Strain Gradients Correlate with Sites of Periosteal Bone Formation , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[42]  I. Owan,et al.  Aging changes mechanical loading thresholds for bone formation in rats , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[43]  T. Skerry,et al.  Inhibition of bone resorption and stimulation of formation by mechanical loading of the modeling rat ulna in vivo , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[44]  M Evans,et al.  Induction of bone formation in rat tail vertebrae by mechanical loading. , 1993, Bone and mineral.

[45]  C. Rubin,et al.  Suppression of the osteogenic response in the aging skeleton , 1992, Calcified Tissue International.

[46]  O H Førde,et al.  The Tromsø Study. Distribution and population determinants of gamma-glutamyltransferase. , 1990, American journal of epidemiology.

[47]  E. Steinhagen-Thiessen,et al.  Long-term physical exercise retards trabecular bone loss in lumbar vertebrae of aging female mice , 1990, Calcified Tissue International.

[48]  N. Kreiger,et al.  Physical activity, body mass index and bone mineral density-associations in a prospective population-based cohort of women and men: the Canadian Multicentre Osteoporosis Study (CaMos). , 2012, Bone.

[49]  F. Lambers.  Functional bone imaging in an in vivo mouse model of bone adaptation, aging and disease , 2011 .

[50]  V. Humphrey,et al.  Ultrasound mimics the effect of mechanical loading on bone formation in vivo on rat ulnae. , 2009, Medical engineering & physics.

[51]  L. Lanyon,et al.  Assessment of the in vivo adaptive response to mechanical loading. , 2008, Methods in molecular biology.

[52]  Harrie Weinans,et al.  Bone loss after OVX is associated with local relative strain, not with global absolute strain , 2006 .

[53]  D B Burr,et al.  Targeted and nontargeted remodeling. , 2002, Bone.

[54]  T. Wronski,et al.  Time course of vertebral osteopenia in ovariectomized rats. , 1989, Bone.