Some clinical effects of midazolam premedication in propofol-induced and isoflurane-maintained anaesthesia in dogs during ovariohysterectomy.

In a randomised, placebo-controlled clinical trial, anaesthesia was induced with propofol (4 mg/kg) after intravenous premedication with or without midazolam (0.1 mg/kg), in a group of 8 dogs scheduled for ovariohysterectomy. Midazolam administration induced acute behavioural changes, and increased reflex suppression after propofol induction. Compared to the control group, the dose required to obtain loss of the pedal reflex was significantly reduced by 37%, and the end-tidal isoflurane concentration during maintenance, reduced by 23%.

[1]  L. Bester,et al.  Some cardiopulmonary effects of midazolam premedication in clenbuterol-treated bitches during surgical endoscopic examination of the uterus and ovariohysterectomy. , 2001, Journal of the South African Veterinary Association.

[2]  T. Mammoto,et al.  Midazolam premedication reduces propofol requirements for sedation during regional anesthesia , 2000, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[3]  G. Stegmann.  Observations on the use of midazolam for sedation, and induction of anaesthesia with midazolam in combination with ketamine in the goat. , 1998, Journal of the South African Veterinary Association.

[4]  J. Ilkiw,et al.  The behaviour of healthy awake cats following intravenous and intramuscular administration of midazolam. , 1996, Journal of veterinary pharmacology and therapeutics.

[5]  A. Waterman,et al.  Antinociceptive activity of midazolam in sheep. , 1995, Journal of veterinary pharmacology and therapeutics.

[6]  R. Moon,et al.  Effects of clenbuterol hydrochloride on pulmonary gas exchange and hemodynamics in anesthetized horses. , 1993, American journal of veterinary research.

[7]  G. Benson,et al.  Thiamylal-sparing effect of midazolam for canine endotracheal intubation. A clinical study of 118 dogs. , 1993, Veterinary surgery : VS.

[8]  D. Greenblatt,et al.  Pharmacokinetics and preliminary observations of behavioral changes following administration of midazolam to dogs. , 1992, Journal of veterinary pharmacology and therapeutics.

[9]  J. Dembo.  Propofol and midazolam act synergistically in combination , 1992 .

[10]  M. Swindle,et al.  Sedative and cardiovascular effects of midazolam in swine. , 1991, Laboratory animal science.

[11]  K. Isenberg,et al.  Insights into the structure and function of GABA-benzodiazepine receptors: ion channels and psychiatry. , 1991, The American journal of psychiatry.

[12]  R. Amrein,et al.  Pharmacology of Dormicum (midazolam) and Anexate (flumazenil) , 1990, Acta anaesthesiologica Scandinavica. Supplementum.

[13]  A. van Miert,et al.  Appetite-modulating drugs in dwarf goats, with special emphasis on benzodiazepine-induced hyperphagia and its antagonism by flumazenil and RO 15-3505. , 1989, Journal of veterinary pharmacology and therapeutics.

[14]  I. Yamamoto,et al.  Bronchodilating and cardiovascular effects of intraduodenally and orally administered clenbuterol in dogs. , 1985, Arzneimittel-Forschung.

[15]  R. Sams,et al.  Pharmacodynamic and pharmacokinetic properties of diazepam in horses. , 1982, American journal of veterinary research.

[16]  H. Mohler,et al.  Benzodiazepine receptor: demonstration in the central nervous system , 1977, Science.

[17]  E. Steffey,et al.  Isoflurane potency in the dog and cat. , 1977, American journal of veterinary research.

[18]  C. Saint-Maurice.  [Nonbarbiturate intravenous anesthetics]. , 1971, Cahiers d'anesthesiologie.