In Vivo Model of Human Pathogen Infection and Demonstration of Efficacy by an Antimicrobial Pouch for Pacing Devices

Background: Device‐related infections represent a significant clinical challenge. Once established, these infections prove difficult to treat with existing antibiotic regimens, compromising the health of device recipients, and usually requiring surgical intervention to resolve.

[1]  D. Uslan Infections of electrophysiologic cardiac devices , 2008, Expert review of medical devices.

[2]  K. Slavin Neuronavigation in neurosurgery: current state of affairs , 2008, Expert review of medical devices.

[3]  David L Hayes,et al.  Management and outcome of permanent pacemaker and implantable cardioverter-defibrillator infections. , 2007, Journal of the American College of Cardiology.

[4]  R. Darouiche,et al.  In vivo efficacy of antimicrobial-coated devices. , 2007, The Journal of bone and joint surgery. American volume.

[5]  S. Saba,et al.  Rising rates of cardiac rhythm management device infections in the United States: 1996 through 2003. , 2006, Journal of the American College of Cardiology.

[6]  S. Gordon Antibiotic prophylaxis against postoperative wound infections. , 2006, Cleveland Clinic journal of medicine.

[7]  D Lacroix,et al.  Local symptoms at the site of pacemaker implantation indicate latent systemic infection , 2004, Heart.

[8]  R. Darouiche,et al.  In Vitro Activity and In Vivo Efficacy of Antimicrobial-coated Vascular Grafts , 2004, Annals of vascular surgery.

[9]  A. Pavie,et al.  [Guidelines on prevention, diagnosis and treatment of infective endocarditis. Executive summary]. , 2004, Revista espanola de cardiologia.

[10]  R. Darouiche,et al.  Treatment of infections associated with surgical implants. , 2004, The New England journal of medicine.

[11]  Walter R Wilson,et al.  Nonvalvular Cardiovascular Device–Related Infections , 2003, Circulation.

[12]  J. Olson,et al.  Efficacy of antimicrobial-impregnated external ventricular drain catheters: a prospective, randomized, controlled trial. , 2003, Journal of neurosurgery.

[13]  R. Darouiche,et al.  Activity of Antimicrobial-Impregnated Silicone Tissue Expanders , 2002, Annals of plastic surgery.

[14]  R. Darouiche,et al.  Efficacy of antimicrobial-impregnated silicone sections from penile implants in preventing device colonization in an animal model. , 2002, Urology.

[15]  M. Cabana,et al.  Why don't physicians follow clinical practice guidelines? A framework for improvement. , 1999, JAMA.

[16]  O. Wenker,et al.  A comparison of two antimicrobial-impregnated central venous catheters. Catheter Study Group. , 1999, The New England journal of medicine.

[17]  K Isaaz,et al.  Antibiotic prophylaxis for permanent pacemaker implantation: a meta-analysis. , 1998, Circulation.