mTOR as a central hub of nutrient signalling and cell growth

[1]  Min Huang,et al.  Cryo-EM structure of human mTOR complex 2 , 2018, Cell Research.

[2]  Christopher H. S. Aylett,et al.  Architecture of the human mTORC2 core complex , 2018, eLife.

[3]  Peng-Yuan Yang,et al.  Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations. , 2018, Cell metabolism.

[4]  M. Hall,et al.  Architecture of the human mTORC 2 core complex , 2018 .

[5]  J. Blenis,et al.  Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling , 2017, Cell.

[6]  A. Tee,et al.  Exploiting cancer vulnerabilities: mTOR, autophagy, and homeostatic imbalance. , 2017, Essays in biochemistry.

[7]  N. Pavletich,et al.  Structural Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40 , 2017, Nature.

[8]  S. Gygi,et al.  SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway , 2017, Science.

[9]  Matthew P. Johnson.  Correction: Photosynthesis , 2017, Essays in biochemistry.

[10]  D. Sabatini.  Twenty-five years of mTOR: Uncovering the link from nutrients to growth , 2017, Proceedings of the National Academy of Sciences.

[11]  Gregory A. Wyant,et al.  mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient , 2017, Cell.

[12]  Y. C. Long,et al.  Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation , 2017, Nature Communications.

[13]  N. Nikitakis.  Glimpses of the near future: a new generation of mTOR inhibitors. , 2017, Oral diseases.

[14]  William A Weiss,et al.  A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. , 2017, Cancer cell.

[15]  David M. Sabatini,et al.  mTOR Signaling in Growth, Metabolism, and Disease , 2017, Cell.

[16]  D. Sabatini,et al.  mTOR Signaling in Growth, Metabolism, and Disease , 2017, Cell.

[17]  Ming O. Li,et al.  SZT2 dictates GATOR control of mTORC1 signalling , 2017, Nature.

[18]  Gregory A. Wyant,et al.  KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 , 2017, Nature.

[19]  Jin Chen,et al.  mTORC1 and mTORC2 in cancer and the tumor microenvironment , 2016, Oncogene.

[20]  Gu,et al.  KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 , 2017, Nature.

[21]  D. Sabatini,et al.  Mechanism of arginine sensing by CASTOR1 upstream of mTORC1 , 2016, Nature.

[22]  Gregory A. Wyant,et al.  The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway , 2016, Cell.

[23]  D. Sabatini,et al.  Sestrin2 is a leucine sensor for the mTORC1 pathway , 2016, Science.

[24]  Michael N. Hall,et al.  Architecture of human mTOR complex 1 , 2016, Science.

[25]  D. Sabatini,et al.  Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway , 2016, Science.

[26]  R. Jaenisch,et al.  Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity , 2015, eLife.

[27]  S. Barrans,et al.  Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma , 2015, Nature Genetics.

[28]  R. Jaenisch,et al.  Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity , 2016, eLife.

[29]  D. Sabatini,et al.  Sestrin 2 is a leucine sensor for the mTORC 1 pathway , 2016 .

[30]  J. Sheen,et al.  Novel links in the plant TOR kinase signaling network. , 2015, Current opinion in plant biology.

[31]  D. Tuveson,et al.  The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1 , 2015, Cell.

[32]  Michael J. Munson,et al.  mTOR activates the VPS34–UVRAG complex to regulate autolysosomal tubulation and cell survival , 2015, The EMBO journal.

[33]  F. Tsai,et al.  Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1. , 2015, Molecular cell.

[34]  Mingyao Liu,et al.  The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. , 2015, Molecular cell.

[35]  C. Behrends,et al.  Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9 , 2015, Molecular and Cellular Biology.

[36]  M. Volpe,et al.  mTORC2 regulates cardiac response to stress by inhibiting MST1. , 2015, Cell reports.

[37]  Q. Zhong.  Faculty Opinions recommendation of Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma. , 2015 .

[38]  Gregory A. Wyant,et al.  Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 , 2015, Science.

[39]  K. Guan,et al.  Differential regulation of mTORC1 by leucine and glutamine , 2015, Science.

[40]  G. Superti-Furga,et al.  SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1 , 2014, Nature.

[41]  Mingyao Liu,et al.  The Ubiquitination of RagA GTPase by RNF 152 Negatively Regulates mTORC 1 Activation , 2015 .

[42]  Michael J. Munson,et al.  mTOR activates the VPS 34 – UVRAG complex to regulate autolysosomal tubulation and cell survival , 2015 .

[43]  Wei Wang,et al.  Sestrins inhibit mTORC1 kinase activation through the GATOR complex. , 2014, Cell reports.

[44]  Steven P Gygi,et al.  The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. , 2014, Cell reports.

[45]  Nikhil Wagle,et al.  Response and acquired resistance to everolimus in anaplastic thyroid cancer. , 2014, The New England journal of medicine.

[46]  J. Blenis,et al.  The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation , 2014, Current Biology.

[47]  Florian Rudroff,et al.  Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins* , 2014, The Journal of Biological Chemistry.

[48]  A. Alavi,et al.  Combined MTOR and autophagy inhibition , 2014, Autophagy.

[49]  Andrew H. Beck,et al.  A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. , 2014, Cancer discovery.

[50]  L. Cantley,et al.  Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome , 2014, Cell.

[51]  S. Gygi,et al.  The Sestrins Interact with GATOR 2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC 1 Citation , 2014 .

[52]  J. Blenis,et al.  Regulates Glutamine Metabolism through the eIF 4 B-Dependent Control of c-Myc Translation , 2014 .

[53]  M. Cobb,et al.  Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals , 2013, Proceedings of the National Academy of Sciences.

[54]  D. Sabatini,et al.  The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. , 2013, Molecular cell.

[55]  S. Ferguson,et al.  Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases , 2013, The Journal of cell biology.

[56]  K. Guan,et al.  Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy , 2013, Autophagy.

[57]  D. Sabatini,et al.  mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin , 2013, Science.

[58]  N. Pavletich,et al.  mTOR kinase structure, mechanism and regulation by the rapamycin-binding domain , 2013, Nature.

[59]  Matthew Meyerson,et al.  A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1 , 2013, Science.

[60]  J. Martina,et al.  Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes , 2013, The Journal of cell biology.

[61]  O. Kirak,et al.  Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival , 2012, Nature.

[62]  B. Su,et al.  mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8. , 2012, Molecular cell.

[63]  N. Sonenberg,et al.  eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies. , 2012, Cancer research.

[64]  D. Sabatini,et al.  Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1 , 2012, Cell.

[65]  E. Gottlieb,et al.  Glutaminolysis activates Rag-mTORC1 signaling. , 2012, Molecular cell.

[66]  Timothy J Griffin,et al.  SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. , 2012, Molecular cell.

[67]  Yong Chen,et al.  MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB , 2012, Autophagy.

[68]  C. De Virgilio,et al.  Leucyl-tRNA synthetase controls TORC1 via the EGO complex. , 2012, Molecular cell.

[69]  Sunghoon Kim,et al.  Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway , 2012, Cell.

[70]  Dudley Lamming,et al.  Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity , 2012, Science.

[71]  Nicholas T. Ingolia,et al.  The translational landscape of mTOR signalling steers cancer initiation and metastasis , 2012, Nature.

[72]  A. Ballabio,et al.  A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB , 2012, The EMBO journal.

[73]  T. Griffin,et al.  Supplemental Information SH 3 BP 4 Is a Negative Regulator of Amino Acid-Rag GTPase-mTORC 1 Signaling , 2012 .

[74]  M. Hall,et al.  Rapamycin passes the torch: a new generation of mTOR inhibitors , 2011, Nature Reviews Drug Discovery.

[75]  Roberto Zoncu,et al.  mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase , 2011, Science.

[76]  Sarat Chandarlapaty,et al.  mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling. , 2011, Cancer discovery.

[77]  Anne E Carpenter,et al.  mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway , 2011, Cell.

[78]  D. Corey,et al.  Regulation of TFEB and V-ATPases by mTORC1 , 2011, The EMBO journal.

[79]  M. Radi,et al.  ATP-competitive inhibitors of mTOR: an update. , 2011, Current medicinal chemistry.

[80]  K. Guan,et al.  Amino acid signaling in TOR activation. , 2011, Annual review of biochemistry.

[81]  B. Viollet,et al.  AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 , 2011, Nature Cell Biology.

[82]  D. Sabatini,et al.  mTORC 1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H +-ATPase , 2011 .

[83]  Q. She,et al.  4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors. , 2010, Cancer cell.

[84]  Qicheng Ma,et al.  Activation of a metabolic gene regulatory network downstream of mTOR complex 1. , 2010, Molecular cell.

[85]  D. Hailey,et al.  Autophagy termination and lysosome reformation regulated by mTOR , 2010, Nature.

[86]  T. P. Neufeld,et al.  Regulation of mTORC1 by the Rab and Arf GTPases* , 2010, The Journal of Biological Chemistry.

[87]  D. Hailey,et al.  Autophagy termination and lysosome reformation regulated by mTOR , 2010, Nature.

[88]  D. Sabatini,et al.  Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids , 2010, Cell.

[89]  K. Shokat,et al.  Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. , 2010, Cancer cell.

[90]  Nicolas Panchaud,et al.  The Vam6 GEF controls TORC1 by activating the EGO complex. , 2009, Molecular cell.

[91]  Zuquan Zou,et al.  A novel dual PI3Kalpha/mTOR inhibitor PI-103 with high antitumor activity in non-small cell lung cancer cells. , 2009, International journal of molecular medicine.

[92]  J. Guan,et al.  Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. , 2009, Molecular biology of the cell.

[93]  C. Jung,et al.  ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. , 2009, Molecular biology of the cell.

[94]  D. Sabatini,et al.  An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1* , 2009, Journal of Biological Chemistry.

[95]  Jeffrey P. MacKeigan,et al.  Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy , 2009, Cell.

[96]  Robbie Loewith,et al.  Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2 , 2009, PLoS biology.

[97]  Michael Karin,et al.  p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling , 2009, Cell.

[98]  D. Alessi,et al.  mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). , 2008, The Biochemical journal.

[99]  Sang Gyun Kim,et al.  Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation , 2008, Proceedings of the National Academy of Sciences.

[100]  T. P. Neufeld,et al.  Regulation of TORC1 by Rag GTPases in nutrient response , 2008, Nature Cell Biology.

[101]  David M. Sabatini,et al.  The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1 , 2008, Science.

[102]  B. Turk,et al.  AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.

[103]  J. Blenis,et al.  SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs , 2008, Cell.

[104]  Suzanne F. Jones,et al.  Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[105]  P. Choyke,et al.  Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. , 2008, Journal of the National Cancer Institute.

[106]  Ernesto Arias-Palomo,et al.  Structure of TOR and its complex with KOG1. , 2007, Molecular cell.

[107]  David M Sabatini,et al.  Defining the role of mTOR in cancer. , 2007, Cancer cell.

[108]  S. Carr,et al.  PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. , 2007, Molecular cell.

[109]  Timothy J. Griffin,et al.  Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 , 2007, Nature Cell Biology.

[110]  Michele Pagano,et al.  S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth , 2006, Science.

[111]  K. Inoki,et al.  Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. , 2006, Genes & development.

[112]  J. Qin,et al.  SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity , 2006, Cell.

[113]  P. Crino,et al.  The tuberous sclerosis complex. , 2006, The New England journal of medicine.

[114]  Jacob D. Jaffe,et al.  mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s , 2006, Current Biology.

[115]  Ming You,et al.  TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth , 2006, Cell.

[116]  C. Kaiser,et al.  A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast , 2006, Nature Cell Biology.

[117]  D. Sabatini,et al.  Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. , 2006, Molecular cell.

[118]  M. Hall,et al.  TOR Signaling in Growth and Metabolism , 2006, Cell.

[119]  J. Bos,et al.  Regulation of the small GTPase Rheb by amino acids , 2006, Oncogene.

[120]  Steven P. Gygi,et al.  mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events , 2005, Cell.

[121]  R. Loewith,et al.  Molecular Organization of Target of Rapamycin Complex 2* , 2005, Journal of Biological Chemistry.

[122]  David M Sabatini,et al.  An expanding role for mTOR in cancer. , 2005, Trends in molecular medicine.

[123]  E. Cameroni,et al.  The TOR and EGO protein complexes orchestrate microautophagy in yeast. , 2005, Molecular cell.

[124]  Joseph Avruch,et al.  Rheb Binds and Regulates the mTOR Kinase , 2005, Current Biology.

[125]  Paul Tempst,et al.  Phosphorylation and Functional Inactivation of TSC2 by Erk Implications for Tuberous Sclerosisand Cancer Pathogenesis , 2005, Cell.

[126]  D. Guertin,et al.  Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.

[127]  R. Loewith,et al.  Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive , 2004, Nature Cell Biology.

[128]  Steven P Gygi,et al.  Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[129]  D. Guertin,et al.  Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton , 2004, Current Biology.

[130]  T. Golub,et al.  mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways , 2004, Nature Medicine.

[131]  Ted Powers,et al.  TOR Complex 1 Includes a Novel Component, Tco89p (YPL180w), and Cooperates with Ssd1p to Maintain Cellular Integrity in Saccharomyces cerevisiae* , 2004, Journal of Biological Chemistry.

[132]  K. Inoki,et al.  TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival , 2003, Cell.

[133]  J. Blenis,et al.  Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb , 2003, Current Biology.

[134]  E. Hafen,et al.  Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. , 2003, Molecular cell.

[135]  J. Blenis,et al.  TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function , 2003, Current Biology.

[136]  J. Avruch,et al.  The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif* , 2003, The Journal of Biological Chemistry.

[137]  A. Chajut,et al.  Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability , 2002, Oncogene.

[138]  J. Crespo,et al.  Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. , 2002, Molecular cell.

[139]  Tian Xu,et al.  Akt regulates growth by directly phosphorylating Tsc2 , 2002, Nature Cell Biology.

[140]  K. Inoki,et al.  TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling , 2002, Nature Cell Biology.

[141]  Maria Merino,et al.  Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome. , 2002, Cancer cell.

[142]  J. Avruch,et al.  Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action , 2002, Cell.

[143]  D. Sabatini,et al.  mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery , 2002, Cell.

[144]  J. Blenis,et al.  Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. , 2002, Molecular cell.

[145]  Kathryn E. Hentges,et al.  FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[146]  J. Blenis,et al.  An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[147]  T. P. Neufeld,et al.  Regulation of cellular growth by the Drosophila target of rapamycin dTOR. , 2000, Genes & development.

[148]  S. Gygi,et al.  Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. , 1999, Genes & development.

[149]  Christine C. Hudson,et al.  Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. , 1997, Science.

[150]  M. Hall,et al.  TOR2 is required for organization of the actin cytoskeleton in yeast. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[151]  A. Gingras,et al.  Rapamycin blocks the phosphorylation of 4E‐BP1 and inhibits cap‐dependent initiation of translation. , 1996, The EMBO journal.

[152]  I. Stansfield,et al.  An MBoC Favorite: TOR controls translation initiation and early G1 progression in yeast , 2012, Molecular biology of the cell.

[153]  Stuart L. Schreiber,et al.  TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin , 1995, Cell.

[154]  R. Abraham,et al.  Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells (*) , 1995, The Journal of Biological Chemistry.

[155]  M. Mclaughlin,et al.  Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue. , 1994, The Journal of biological chemistry.

[156]  V. Berlin,et al.  RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[157]  Paul Tempst,et al.  RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs , 1994, Cell.

[158]  Stuart L. Schreiber,et al.  A mammalian protein targeted by G1-arresting rapamycin–receptor complex , 1994, Nature.

[159]  D. Kwiatkowski,et al.  Tuberous sclerosis. , 1994, Archives of dermatology.

[160]  M. Mclaughlin,et al.  Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity , 1993, Molecular and cellular biology.

[161]  S. Sehgal,et al.  Rapamycin: In Vitro Profile of a New Immunosuppressive Macrolide. , 1993, Annals of the New York Academy of Sciences.

[162]  J. Kunz,et al.  Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression , 1993, Cell.

[163]  G. Crabtree,et al.  Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase , 1992, Nature.

[164]  G. Crabtree,et al.  Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases , 1992, Cell.

[165]  J. Heitman,et al.  Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast , 1991, Science.

[166]  D. Bergsma,et al.  Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein , 1991 .

[167]  D. Bergsma,et al.  Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein. , 1991, Molecular and cellular biology.

[168]  J. Heitman,et al.  FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[169]  K. O. Elliston,et al.  FKBl encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[170]  S. Schreiber,et al.  Chemistry and biology of the immunophilins and their immunosuppressive ligands. , 1991, Science.

[171]  N. Sigal,et al.  The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells. , 1990, Journal of immunology.

[172]  N. Sigal,et al.  Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin. , 1990, Journal of immunology.

[173]  S. Sehgal,et al.  Activity of rapamycin (AY-22,989) against transplanted tumors. , 1984, The Journal of antibiotics.

[174]  K. Johnson.  An Update. , 1984, Journal of food protection.

[175]  J. Douros,et al.  New antitumor substances of natural origin. , 1981, Cancer treatment reviews.

[176]  S. Sun,et al.  Rapamycin (AY-22,989), a new antifungal antibiotic. IV. Mechanism of action. , 1979, The Journal of antibiotics.

[177]  S. Sehgal,et al.  Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation. , 1978, The Journal of antibiotics.

[178]  S. Sehgal,et al.  Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. , 1975, The Journal of antibiotics.

[179]  S. Sehgal,et al.  Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. , 1975, The Journal of antibiotics.

[180]  T. S. P. S.,et al.  GROWTH , 1924, Nature.

[181]  Zuquan Zou,et al.  A novel dual PI 3 K · / mTOR inhibitor PI-103 with high antitumor activity in non-small cell lung cancer cells , 2022 .