The role of the intrinsic electrophysiological properties of central neurones in oscillation and resonance

Publisher Summary This chapter discusses the role of the intrinsic electrophysiological properties of central neurons in oscillation and resonance. In vitro experiments using brainstem slices have demonstrated that inferior olive neurons have a set of ionic conductances that are activated in such a way as to give these cells intrinsic oscillatory properties. The firing of inferior olive cells is characterized by an initial fast-rising action potential, which is prolonged to 10–15 ms by an after-depolarization. The abrupt, long-lasting after-hyperpolarization the plateau after-depolarization totally silences the spike generating activity. This hyperpolarization is typically terminated by a sharp, active rebound response, which arises when the membrane potential is negative to the resting level. When this rebound reaches threshold for an action potential, the cell is again activated. In this way, the cell will fire at a frequency determined largely by the characteristics of the after-hyperpolarization.

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