Fabrication of nanostructured polymeric films and their geometric effects on cell growth

Nanoscaled inverse opal colloid crystal scaffolds with tunable structure based on various biomedical polymers have been fabricated via colloidal crystal templates. Bone marrow-derived mesenchyme stem cells (MSCs) were used to test the cellular compatibility of these nanostructured polymeric films. Cell morphology and viability were investigated by SEM and fluorescence staining, respectively. The results indicate that the MSCs can sense the nanoscale topographic features and grow well on the inverse opal scaffolds, which may imply potential applications in tissue engineering.