Poloxamers and poloxamines in nanoparticle engineering and experimental medicine.

Poloxamers and poloxamine nonionic surfactants have diverse applications in various biomedical fields ranging from drug delivery and medical imaging to management of vascular diseases and disorders. Although this is a progressive, rapidly advancing field in biotechnology, the future will depend on the recognition and rectification of a range of toxicity issues, which have to be addressed but have frequently been ignored until now.

[1]  V. Alakhov,et al.  Hypersensitizing effect of pluronic L61 on cytotoxic activity, transport, and subcellular distribution of doxorubicin in multiple drug-resistant cells. , 1996, Cancer research.

[2]  E. Roden,et al.  Recovery of Humic-Reducing Bacteria from a Diversity of Environments , 1998, Applied and Environmental Microbiology.

[3]  R. Hunter,et al.  The adjuvant activity of nonionic block polymer surfactants. II. Antibody formation and inflammation related to the structure of triblock and octablock copolymers. , 1984, Journal of immunology.

[4]  G. G. Cameron,et al.  Thermal and thermooxidative degradation of poly(ethylene oxide)-metal salt complexes , 1992 .

[5]  R. Hunter,et al.  Induction of macrophage Ia expression in vivo by a synthetic block copolymer, L81. , 1990, Journal of immunology.

[6]  R L Hunter,et al.  Significantly improved oral uptake of amikacin in FVB mice in the presence of CRL-1605 copolymer. , 1999, Life sciences.

[7]  R. Gibbons,et al.  Beneficial effects of RheothRx injection in patients receiving thrombolytic therapy for acute myocardial infarction. Results of a randomized, double-blind, placebo-controlled trial. , 1996, Circulation.

[8]  C. Goodman.  United States Pharmacopeial Convention , 1988 .

[9]  K. Lowe,et al.  Pluronic F-68 inhibits agonist-induced platelet aggregation in human whole blood in vitro. , 1998, Artificial cells, blood substitutes, and immobilization biotechnology.

[10]  R. Nalbandian,et al.  Pluronic F-127 gel preparation as an artificial skin in the treatment of third-degree burns in pigs. , 1987, Journal of biomedical materials research.

[11]  F. Kawai.  Biodegradation of polyethers and polyacrylate , 1994 .

[12]  Agnès Rivaton,et al.  Photooxidative degradation of polyether-based polymers , 1999 .

[13]  H. Simon,et al.  On the reduction of aliphatic and aromatic nitro compounds by Clostridia, the role of ferredoxin and its stabilization. , 1983, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

[14]  S. Davis,et al.  Non-phagocytic uptake of intravenously injected microspheres in rat spleen: influence of particle size and hydrophilic coating. , 1991, Biochemical and biophysical research communications.

[15]  J. Murray,et al.  Phagocytic activation of human neutrophils by the detergent component of fluosol. , 1992, The American journal of pathology.

[16]  R. Lipton,et al.  Phase I clinical and pharmacokinetic study of taxol. , 1987, Cancer research.

[17]  M. Flens,et al.  Tissue distribution of the multidrug resistance protein. , 1996, The American journal of pathology.

[18]  A. Groom,et al.  The Microcirculatory Society Eugene M. Landis award lecture. Microcirculation of the spleen: new concepts, new challenges. , 1987, Microvascular research.

[19]  M. Steinberg,et al.  RheothRx (poloxamer 188) injection for the acute painful episode of sickle cell disease: a pilot study. , 1997, Blood.

[20]  Martindale.,et al.  THE EXTRA PHARMACOPOEIA , 1937 .

[21]  F. Okada,et al.  Enhancement of therapeutic effects of recombinant interleukin 2 on a transplantable rat fibrosarcoma by the use of a sustained release vehicle, pluronic gel. , 1987, Cancer research.

[22]  L. Krumholz,et al.  A freshwater anaerobe coupling acetate oxidation to tetrachloroethylene dehalogenation , 1996, Applied and environmental microbiology.

[23]  Gert Storm,et al.  Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system , 1995 .

[24]  T. Gray,et al.  A single dose of intravenously injected poloxamine-coated long-circulating particles triggers macrophage clearance of subsequent doses in rats. , 1997, Clinical science.

[25]  K. Caldwell,et al.  PLASMA PROTEIN INTERACTIONS WITH PLURONIC-TREATED COLLOIDS , 1996 .

[26]  J. Lloyd,et al.  Reduction of Technetium by Desulfovibrio desulfuricans: Biocatalyst Characterization and Use in a Flowthrough Bioreactor , 1999, Applied and Environmental Microbiology.

[27]  R. Crawford,et al.  Initial-phase optimization for bioremediation of munition compound-contaminated soils , 1993, Applied and environmental microbiology.

[28]  Poloxamer-188 revisited: a potentially valuable immune modulator. , 1996, Journal of the National Cancer Institute.

[29]  Johnston Tp,et al.  Sustained-Release of Urease from a Poloxamer Gel Matrix , 1990 .

[30]  S. Davis,et al.  An investigation of the filtration capacity and the fate of large filtered sterically-stabilized microspheres in rat spleen. , 1993, Biochimica et biophysica acta.

[31]  R. Weichselbaum,et al.  Poloxamine 1107 sealing of radiopermeabilized erythrocyte membranes. , 1999, International journal of radiation biology.

[32]  T. Gray,et al.  Surface engineered nanospheres with enhanced drainage into lymphatics and uptake by macrophages of the regional lymph nodes , 1994, FEBS letters.

[33]  D. Lovley,et al.  Quinone Moieties Act as Electron Acceptors in the Reduction of Humic Substances by Humics-Reducing Microorganisms , 1998 .

[34]  R. Hunter,et al.  Effects of poloxamer 188 in a rabbit model of hemorrhagic shock. , 1994, Annals of clinical and laboratory science.

[35]  Christof Holliger,et al.  Complete Reduction of TNT and Other (Poly)nitroaromatic Compounds under Iron-Reducing Subsurface Conditions , 1999 .

[36]  K. Caldwell,et al.  Surface Properties of Pluronic-Coated Polymeric Colloids , 1994 .

[37]  F M Muggia,et al.  Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: an in vitro study. , 1998, Journal of the National Cancer Institute.

[38]  I. Pastan,et al.  P-glycoproteins: mediators of multidrug resistance. , 1993, Seminars in cell biology.

[39]  V. Kolb-Bachofen,et al.  Coating particles with a block co-polymer (poloxamine-908) suppresses opsonization but permits the activity of dysopsonins in the serum. , 1993, Biochimica et biophysica acta.

[40]  P. Tso,et al.  Dietary supplementation with Pluronic L-81 modifies hepatic secretion of very low density lipoproteins in the rat. , 1986, Journal of lipid research.

[41]  R. Schwarzenbach,et al.  Reduction of nitroaromatic compounds coupled to microbial iron reduction in laboratory aquifer columns. , 1995, Environmental science & technology.

[42]  R. Hunter,et al.  Activities of poloxamer CRL8131 against Mycobacterium tuberculosis in vitro and in vivo , 1995, Antimicrobial agents and chemotherapy.

[43]  M. Newman,et al.  Design and development of adjuvant-active nonionic block copolymers. , 1998, Journal of pharmaceutical sciences.

[44]  E. Eisenhauer,et al.  Clinical toxicities encountered with paclitaxel (Taxol). , 1993, Seminars in oncology.

[45]  M J Dybas,et al.  Effects of medium and trace metals on kinetics of carbon tetrachloride transformation by Pseudomonas sp. strain KC , 1993, Applied and environmental microbiology.

[46]  I. R. Schmolka.  Artificial skin. I. Preparation and properties of pluronic F-127 gels for treatment of burns. , 1972, Journal of biomedical materials research.

[47]  B. Paton,et al.  A study of labeled pluronic F-68 after intravenous injection into the dog. , 1978, The Journal of surgical research.

[48]  J. H. Beijnen,et al.  Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs , 1994, Cell.

[49]  Z. Y. Wang,et al.  Disposition in rats of a polyoxypropylene-polyoxyethylene copolymer used in plasma fractionation. , 1975, Drug metabolism and disposition: the biological fate of chemicals.

[50]  R. Hunter,et al.  The adjuvant activity of nonionic block polymer surfactants. I. The role of hydrophile-lipophile balance. , 1981, Journal of immunology.

[51]  G. Vercellotti,et al.  Activation of plasma complement by perfluorocarbon artificial blood: probable mechanism of adverse pulmonary reactions in treated patients and rationale for corticosteroids prophylaxis , 1982 .

[52]  K. Lowe,et al.  Purification of Pluronic F‐68 for perfluorochemical emulsification * , 1989, The Journal of pharmacy and pharmacology.

[53]  A. Banga,et al.  Controlled release of human growth hormone in rats following parenteral administration of poloxamer gels , 1997 .

[54]  I. Roninson,et al.  Inhibition of cytarabine‐induced MDR1 (P‐glycoprotein) gene activation in human tumor cells by fatty acid‐polyethylene glycol‐fatty acid diesters, novel inhibitors of P‐glycoprotein function , 1996, International journal of cancer.

[55]  Martindale : the extra pharmacopoeia , 1996 .

[56]  G. G. Cameron,et al.  The thermal Degradation of Poly(Propylene Oxide) and its Complexes with LiBr and LiI , 1995 .

[57]  I. R. Schmolka.  Physical basis for poloxamer interactions. , 1994, Annals of the New York Academy of Sciences.

[58]  F. Follis,et al.  Role of poloxamer 188 during recovery from ischemic spinal cord injury: a preliminary study. , 1996, Journal of investigative surgery.

[59]  F. Widdel,et al.  Anaerobic degradation of naphthalene by a pure culture of a novel type of marine sulphate-reducing bacterium. , 1999, Environmental microbiology.

[60]  W. Ludwig,et al.  Complete oxidation of toluene under strictly anoxic conditions by a new sulfate-reducing bacterium , 1993, Applied and environmental microbiology.

[61]  K. Lowe,et al.  Evaluation of commercial and purified Pluronic F-68 in a human blood neutrophil bioassay. , 1999, Artificial cells, blood substitutes, and immobilization biotechnology.

[62]  D. Norris,et al.  Transient cortical blindness secondary to vincristine therapy in childhood malignancies , 1981, Cancer.

[63]  B. Bennett,et al.  The Adjuvant Activity of Nonionic Block Polymer Surfactants , 1986, Scandinavian journal of immunology.

[64]  A. Kabanov,et al.  Interactions of pluronic block copolymers with brain microvessel endothelial cells: evidence of two potential pathways for drug absorption. , 1997, Bioconjugate chemistry.

[65]  S. M. Moghimi.  Prolonging the circulation time and modifying the body distribution of intravenously injected polystyrene nanospheres by prior intravenous administration of poloxamine-908. A 'hepatic-blockade' event or manipulation of nanosphere surface in vivo? , 1997, Biochimica et biophysica acta.

[66]  S. Davis,et al.  Effect of splenic congestion associated with haemolytic anaemia on filtration of 'spleen-homing' microspheres. , 1993, Clinical science.

[67]  W. Weaver,et al.  Randomized, controlled trial of RheothRx (poloxamer 188) in patients with suspected acute myocardial infarction , 1998 .

[68]  W. Bochenek,et al.  Absorption and excretion of the hydrophobic surfactant, 14C-poloxalene 2930, in the rat. , 1984, Drug metabolism and disposition: the biological fate of chemicals.

[69]  Craig S. Criddle,et al.  Motility-Enhanced Bioremediation of Carbon Tetrachloride-Contaminated Aquifer Sediments , 1999 .

[70]  M. Davies,et al.  Differences in the molecular weight profile of poloxamer 407 affect its ability to redirect intravenously administered colloids to the bone marrow , 1992 .

[71]  Raphael C. Lee,et al.  Pharmaceutical Therapies for Sealing of Permeabilized Cell Membranes in Electrical Injuriesa , 1999, Annals of the New York Academy of Sciences.

[72]  W. Konings,et al.  Multidrug transporters from bacteria to man: similarities in structure and function. , 1997, Seminars in cancer biology.

[73]  M. Keltai,et al.  The effect of RheothRx Injection on the hemorheological parameters in patients with acute myocardial infarction. , 1997, Clinical hemorheology and microcirculation.

[74]  Ramaraj Boopathy,et al.  Characterization of partial anaerobic metabolic pathway for 2,4,6-trinitrotoluene degradation by a sulfate-reducing bacterial consortium. , 1996, Canadian journal of microbiology.

[75]  J. Ramos,et al.  Potential of Toluene-Degrading Systems for the Construction of Hybrid Pathways for Nitrotoluene Metabolism , 1995 .

[76]  L. Weiss,et al.  Anatomical hazards to the passage of erythrocytes through the spleen. , 1970, Seminars in hematology.