Phase I/II clinical trials of carbon ion therapy for prostate cancer

Heavy ion beams possess high linear energy transfer components and a prominent Bragg peak in the human body, resulting in higher relative biological effectiveness and improved dose distribution. To establish heavy ion therapy techniques for the treatment of prostate cancer, phase I/II clinical trials were initiated.

[1]  Jacques Bernier,et al.  Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial , 2002, The Lancet.

[2]  D. Hussey American Society for Therapeutic Radiology and Oncology , 2001 .

[3]  G. Hanks,et al.  Updated results of the phase III Radiation Therapy Oncology Group (RTOG) trial 85-31 evaluating the potential benefit of androgen suppression following standard radiation therapy for unfavorable prognosis carcinoma of the prostate. , 2001, International journal of radiation oncology, biology, physics.

[4]  D. Grignon,et al.  Predicting long-term survival, and the need for hormonal therapy: a meta-analysis of RTOG prostate cancer trials. , 2000, International journal of radiation oncology, biology, physics.

[5]  C. Ling,et al.  Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancer. , 1999, International journal of radiation oncology, biology, physics.

[6]  Y. Furuya,et al.  External beam radiation monotherapy for prostate cancer , 1999, International journal of urology : official journal of the Japanese Urological Association.

[7]  S Minohara,et al.  Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. , 1999, International journal of radiation oncology, biology, physics.

[8]  A. Hanlon,et al.  Diabetes mellitus: a predictor for late radiation morbidity. , 1999, International journal of radiation oncology, biology, physics.

[9]  P. Grimm,et al.  A survey of current clinical practice of permanent prostate brachytherapy in the United States. , 1998, International journal of radiation oncology, biology, physics.

[10]  James D. Cox,et al.  Consensus statement: Guidelines for PSA following radiation therapy , 1997 .

[11]  C. Begg,et al.  The indications, rationale, and results of neoadjuvant androgen deprivation in the treatment of prostatic cancer: Memorial Sloan-Kettering Cancer Center results. , 1997, Urology.

[12]  L. Verhey,et al.  Advanced prostate cancer: the results of a randomized comparative trial of high dose irradiation boosting with conformal protons compared with conventional dose irradiation using photons alone. , 1995, International journal of radiation oncology, biology, physics.

[13]  T. Pajak,et al.  Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) , 1995, International journal of radiation oncology, biology, physics.

[14]  S. Hancock,et al.  Control of prostate cancer with radiotherapy: long-term results. , 1994, The Journal of urology.

[15]  K. Akakura,et al.  RADIATION THERAPY FOR PROSTATE CANCER CONFINED TO PELVIS , 1994, International journal of urology : official journal of the Japanese Urological Association.

[16]  K. Russell,et al.  Fast Neutron Radiotherapy for Locally Advanced Prostate Cancer: Final Report of a Radiation Therapy Oncology Group Randomized Clinical Trial , 1993, American journal of clinical oncology.

[17]  T. Phillips,et al.  Neon ion radiotherapy: results of the phase I/II clinical trial. , 1991, International journal of radiation oncology, biology, physics.

[18]  S. Yoo,et al.  Present status of fast neutron therapy in Asian countries. , 1989, Bulletin du cancer. Radiotherapie : journal de la Societe francaise du cancer : organe de la societe francaise de radiotherapie oncologique.

[19]  J. Forman,et al.  Fast Neutron Irradiation for Prostate Cancer , 2004, Cancer and Metastasis Reviews.

[20]  J. Forman,et al.  Fast neutron irradiation for prostate cancer : Clinical and translational research in prostate cancer, part II , 2002 .

[21]  G. Noël,et al.  [Predicting long-term survival, and the need for hormonal therapy: a meta-analysis of RTOG prostate cancer trials]. , 2001, Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique.

[22]  R Mohan,et al.  A feasibility study of automated inverse treatment planning for cancer of the prostate. , 1998, International journal of radiation oncology, biology, physics.

[23]  Daniel W. Miller,et al.  Combined proton and photon conformal radiation therapy for locally advanced carcinoma of the prostate: preliminary results of a phase I/II study. , 1997, International journal of radiation oncology, biology, physics.

[24]  H. Tsujii Preliminary results of Phase I/II carbon-ion therapy , 1997 .

[25]  K. Russell,et al.  Photon versus fast neutron external beam radiotherapy in the treatment of locally advanced prostate cancer: results of a randomized prospective trial. , 1994, International journal of radiation oncology, biology, physics.

[26]  Cornelius A. Tobias,et al.  Heavy-Ion Radiobiology: Cellular Studies , 1984 .

[27]  E. J. Ainsworth,et al.  Heavy-Ion Radiobiology: Normal Tissue Studies , 1983 .

[28]  D. Gleason Classification of prostatic carcinomas. , 1966, Cancer chemotherapy reports.