Preserving expression of Pdx1 improves β-cell failure in diabetic mice.

[1]  I. Shimomura,et al.  Sustained expression of GLP-1 receptor differentially modulates β-cell functions in diabetic and nondiabetic mice. , 2016, Biochemical and biophysical research communications.

[2]  J. Miyazaki,et al.  Preserving Mafa Expression in Diabetic Islet β-Cells Improves Glycemic Control in Vivo* , 2015, The Journal of Biological Chemistry.

[3]  Y. Terauchi,et al.  Glucokinase Activation Ameliorates ER Stress–Induced Apoptosis in Pancreatic β-Cells , 2013, Diabetes.

[4]  Olle Korsgren,et al.  A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets. , 2012, Cell metabolism.

[5]  L. Sussel,et al.  FoxA2, Nkx2.2, and PDX-1 Regulate Islet β-Cell-Specific mafA Expression through Conserved Sequences Located between Base Pairs −8118 and −7750 Upstream from the Transcription Start Site , 2006, Molecular and Cellular Biology.

[6]  S. Akira,et al.  Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. , 2006, Genes & development.

[7]  C. Wright,et al.  Efficient recombination in pancreatic islets by a tamoxifen‐inducible Cre‐recombinase , 2005, Genesis.

[8]  C. Kahn,et al.  PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. , 2004, The Journal of clinical investigation.

[9]  J. Miyazaki,et al.  Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. , 2003, Biochemical and biophysical research communications.

[10]  James D. Johnson,et al.  Increased islet apoptosis in Pdx1+/- mice. , 2003, The Journal of clinical investigation.

[11]  Masataka Mori,et al.  Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. , 2002, The Journal of clinical investigation.

[12]  B. Ahrén,et al.  Altered beta-cell distribution of pdx-1 and GLUT-2 after a short-term challenge with a high-fat diet in C57BL/6J mice. , 2002, Diabetes.

[13]  C. Wollheim,et al.  Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation* , 2001, The Journal of Biological Chemistry.

[14]  Y. Matsuzawa,et al.  Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. , 1999, Diabetes.

[15]  Allen,et al.  Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes , 1999, The Journal of clinical investigation.

[16]  R. Robertson,et al.  In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression. , 1999, Diabetes.

[17]  J. Habener,et al.  Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. , 1998, The Journal of clinical investigation.

[18]  H. Edlund,et al.  beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. , 1998, Genes & development.

[19]  M. Birnbaum,et al.  Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2 , 1997, Nature Genetics.

[20]  Masato Yoshioka,et al.  A Novel Locus, Mody4, Distal to D7Mit189 on Chromosome 7 Determines Early-Onset NIDDM in Nonobese C57BL/6 (Akita) Mutant Mice , 1997, Diabetes.

[21]  H. Kaneto,et al.  The Human Glucokinase Gene β-Cell-Type Promoter: An Essential Role of Insulin Promoter Factor 1/PDX-1 in Its Activation in HIT-T15 Cells , 1996, Diabetes.

[22]  G. Waeber,et al.  Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. , 1996, Molecular endocrinology.

[23]  H. Edlund,et al.  Insulin-promoter-factor 1 is required for pancreas development in mice , 1994, Nature.

[24]  H. Ohlsson,et al.  IPF1, a homeodomain‐containing transactivator of the insulin gene. , 1993, The EMBO journal.

[25]  T. Miyatsuka Chronology of endocrine differentiation and beta-cell neogenesis. , 2016, Endocrine journal.

[26]  Danhong Lu,et al.  A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse. , 1999, The Journal of clinical investigation.

[27]  William L. Clarke,et al.  Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence , 1997, Nature Genetics.