Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial
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Gabriel A. Koepp | Sanjiv J. Shah | K. Anstrom | E. Braunwald | J. Levine | G. Felker | Adrian F. Hernandez | D. Mann | M. LeWinter | D. Whellan | K. Margulies | G. Lewis | W. Tang | S. McNulty | B. Borlaug | M. Redfield | Andrew L. Smith | V. Dávila-Román | M. Givertz | P. Desvigne‐Nickens | Horng H. Chen | A. Hernandez | W. Tang | Andrew L. Smith | Sanjiv J. Shah | Horng H. Chen | G. Lewis | Adrian F. Hernandez | Douglas L. Mann | Martin M Lewinter | W. H. W. Tang | Horng H. Chen | K. Anstrom | Margaret M. Redfield | Kenneth B. Margulies | Gregory D. Lewis | James A. Levine | Gabe A. Koepp | Andrew L. Smith | Martin M. Lewinter | W. W. Tang | M. Redfield
[1] V. Melenovský,et al. Haemodynamics, dyspnoea, and pulmonary reserve in heart failure with preserved ejection fraction , 2018, European heart journal.
[2] V. Melenovský,et al. Hemodynamic Correlates and Diagnostic Role of Cardiopulmonary Exercise Testing in Heart Failure With Preserved Ejection Fraction. , 2018, JACC. Heart failure.
[3] G. Lewis,et al. Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure , 2018, Circulation. Heart failure.
[4] N. Houstis,et al. Exercise Intolerance in Heart Failure With Preserved Ejection Fraction: Diagnosing and Ranking Its Causes Using Personalized O2 Pathway Analysis , 2017, Circulation.
[5] Ashley R. Morgan,et al. Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction. , 2017, Nitric oxide : biology and chemistry.
[6] V. Melenovský,et al. Arterial Stiffening With Exercise in Patients With Heart Failure and Preserved Ejection Fraction. , 2017, Journal of the American College of Cardiology.
[7] V. Melenovský,et al. Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction , 2017, Circulation.
[8] S. Russell,et al. Fatigability, Exercise Intolerance, and Abnormal Skeletal Muscle Energetics in Heart Failure , 2017, Circulation. Heart failure.
[9] Sanjiv J. Shah,et al. INDIE-HFpEF (Inorganic Nitrite Delivery to Improve Exercise Capacity in Heart Failure With Preserved Ejection Fraction): Rationale and Design. , 2017, Circulation. Heart failure.
[10] R. Townsend,et al. Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction , 2017, Circulation research.
[11] Sanjiv J. Shah,et al. Vericiguat in patients with worsening chronic heart failure and preserved ejection fraction: results of the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED EF (SOCRATES-PRESERVED) study , 2017, European heart journal.
[12] Gabriel A. Koepp,et al. Accelerometer-Measured Daily Activity in Heart Failure With Preserved Ejection Fraction: Clinical Correlates and Association With Standard Heart Failure Severity Indices , 2016, Circulation. Heart failure.
[13] J. Dammin. Case 39-2016: A Man with a History of Prostate Cancer and Recent Rectal Bleeding. , 2017, The New England journal of medicine.
[14] M. Gladwin,et al. Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction. , 2016, JCI insight.
[15] V. Melenovský,et al. Inhaled Sodium Nitrite Improves Rest and Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction. , 2016, Circulation research.
[16] D. Kitzman,et al. One Week of Daily Dosing With Beetroot Juice Improves Submaximal Endurance and Blood Pressure in Older Patients With Heart Failure and Preserved Ejection Fraction. , 2016, JACC. Heart failure.
[17] Gabriel A. Koepp,et al. Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction. , 2015, The New England journal of medicine.
[18] Frederick A. Masoudi,et al. Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction , 2015 .
[19] V. Melenovský,et al. Sodium Nitrite Improves Exercise Hemodynamics and Ventricular Performance in Heart Failure With Preserved Ejection Fraction. , 2015, Journal of the American College of Cardiology.
[20] A. Coggan,et al. Acute Dietary Nitrate Intake Improves Muscle Contractile Function in Patients With Heart Failure: A Double-Blind, Placebo-Controlled, Randomized Trial , 2015, Circulation. Heart failure.
[21] A. Shah,et al. Central cardiac limit to aerobic capacity in patients with exertional pulmonary venous hypertension: implications for heart failure with preserved ejection fraction. , 2015, Circulation. Heart failure.
[22] N. Houstis,et al. Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction: The Role of Abnormal Peripheral Oxygen Extraction , 2015, Circulation. Heart failure.
[23] A. Webb,et al. Paradoxical Normoxia-Dependent Selective Actions of Inorganic Nitrite in Human Muscular Conduit Arteries and Related Selective Actions on Central Blood Pressures , 2015, Circulation.
[24] R. Townsend,et al. Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure With Preserved Ejection Fraction , 2015, Circulation.
[25] Gabriel A. Koepp,et al. Nitrate’s Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction Trial: Rationale and Design , 2015, Circulation. Heart failure.
[26] Ambarish Pandey,et al. Exercise Training in Patients With Heart Failure and Preserved Ejection Fraction: Meta-Analysis of Randomized Control Trials , 2014, Circulation. Heart failure.
[27] Robert J Mentz,et al. Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction. , 2014, Journal of the American College of Cardiology.
[28] M. Gladwin,et al. Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Nebulized Sodium Nitrite (AIR001) Following Repeat-Dose Inhalation in Healthy Subjects , 2014, Clinical Pharmacokinetics.
[29] W. Kraus,et al. Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. , 2014, American journal of physiology. Heart and circulatory physiology.
[30] B. Nicklas,et al. Skeletal muscle composition and its relation to exercise intolerance in older patients with heart failure and preserved ejection fraction. , 2014, The American journal of cardiology.
[31] Wolfgang A. Linke,et al. Heart failure with preserved ejection fraction , 2014, Pflügers Archiv - European Journal of Physiology.
[32] W. Paulus,et al. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. , 2013, Journal of the American College of Cardiology.
[33] I. Piña,et al. Forecasting the Impact of Heart Failure in the United States: A Policy Statement From the American Heart Association , 2013, Circulation. Heart failure.
[34] Manesh R. Patel,et al. Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial. , 2013, JAMA.
[35] E. Braunwald,et al. PhosphdiesteRasE-5 Inhibition to Improve CLinical Status and EXercise Capacity in Diastolic Heart Failure (RELAX) trial: rationale and design. , 2012, Circulation. Heart failure.
[36] W. Kraus,et al. Modest Increase in Peak VO2 Is Related to Better Clinical Outcomes in Chronic Heart Failure Patients: Results From Heart Failure and a Controlled Trial to Investigate Outcomes of Exercise Training , 2012, Circulation. Heart failure.
[37] J. Bronzwaer,et al. Low Myocardial Protein Kinase G Activity in Heart Failure With Preserved Ejection Fraction , 2012, Circulation.
[38] R. Nishimura,et al. Effects of vasodilation in heart failure with preserved or reduced ejection fraction implications of distinct pathophysiologies on response to therapy. , 2012, Journal of the American College of Cardiology.
[39] D. Logeart,et al. Increased proximal arterial stiffness and cardiac response with moderate exercise in patients with heart failure and preserved ejection fraction. , 2012, Journal of the American College of Cardiology.
[40] B. Adams-Huet,et al. Abnormal haemodynamic response to exercise in heart failure with preserved ejection fraction , 2011, European journal of heart failure.
[41] D. Kitzman,et al. Determinants of exercise intolerance in elderly heart failure patients with preserved ejection fraction. , 2011, Journal of the American College of Cardiology.
[42] S. Ommen,et al. Diastolic relaxation and compliance reserve during dynamic exercise in heart failure with preserved ejection fraction , 2011, Heart.
[43] W. Paulus,et al. Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. , 2011, European heart journal.
[44] K. Sahlin,et al. Dietary inorganic nitrate improves mitochondrial efficiency in humans. , 2011, Cell metabolism.
[45] Amir Lerman,et al. Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction. , 2010, Journal of the American College of Cardiology.
[46] H. Brunner-La Rocca,et al. Hemodynamic basis of exercise limitation in patients with heart failure and normal ejection fraction. , 2010, Journal of the American College of Cardiology.
[47] R. Nishimura,et al. Exercise Hemodynamics Enhance Diagnosis of Early Heart Failure With Preserved Ejection Fraction , 2010, Circulation. Heart failure.
[48] Jamie R. Blackwell,et al. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. , 2009, Journal of applied physiology.
[49] A. Henning,et al. Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency. , 2009, Journal of the American College of Cardiology.
[50] V. Roger,et al. Contractility and ventricular systolic stiffening in hypertensive heart disease insights into the pathogenesis of heart failure with preserved ejection fraction. , 2009, Journal of the American College of Cardiology.
[51] Yu Ting Tan,et al. The pathophysiology of heart failure with normal ejection fraction: exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion. , 2009, Journal of the American College of Cardiology.
[52] W. Kraus,et al. Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. , 2009, JAMA.
[53] J. Bronzwaer,et al. Hypophosphorylation of the Stiff N2B Titin Isoform Raises Cardiomyocyte Resting Tension in Failing Human Myocardium , 2009, Circulation research.
[54] Rebekah A. Weaver,et al. Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans , 2008, Circulation.
[55] Mark T. Gladwin,et al. The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics , 2008, Nature Reviews Drug Discovery.
[56] M. Gladwin,et al. Nitrite Infusion in Humans and Nonhuman Primates: Endocrine Effects, Pharmacokinetics, and Tolerance Formation , 2007, Circulation.
[57] B. Ekblom,et al. Effects of dietary nitrate on oxygen cost during exercise , 2007, Acta physiologica.
[58] D. Kass,et al. Impaired Chronotropic and Vasodilator Reserves Limit Exercise Capacity in Patients With Heart Failure and a Preserved Ejection Fraction , 2006, Circulation.
[59] V. Roger,et al. Trends in prevalence and outcome of heart failure with preserved ejection fraction. , 2006, The New England journal of medicine.
[60] Wolfgang A Linke,et al. Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure , 2006, Circulation.
[61] R. Arena,et al. Cardiopulmonary exercise testing in the clinical and prognostic assessment of diastolic heart failure. , 2005, Journal of the American College of Cardiology.
[62] T. Münzel,et al. Explaining the phenomenon of nitrate tolerance. , 2005, Circulation research.
[63] J. Stoner,et al. Cross-Over Trials in Clinical Research (2nd ed.) (Book) , 2004 .
[64] M. Gladwin,et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation , 2003, Nature Medicine.
[65] P R Jackson,et al. Cross over trials. , 1996, British journal of clinical pharmacology.
[66] V. Froelicher,et al. Exercise standards. A statement for healthcare professionals from the American Heart Association. Writing Group. , 1995, Circulation.
[67] V. Froelicher,et al. Exercise standards. A statement for health professionals from the American Heart Association. , 1990, Circulation.
[68] Douglas G. Altman,et al. Practical statistics for medical research , 1990 .
[69] B. Amor,et al. Nicardipine in the Treatment of Raynaud's Phenomenon: A Randomized Double-Blind Trial , 1987, Angiology.
[70] J. Grizzle. THE TWO-PERIOD CHANGE-OVER DESIGN AN ITS USE IN CLINICAL TRIALS. , 1965, Biometrics.