SECONDARY METABOLITES FOUND IN BERGENIA SPECIES: A COMPENDIOUS REVIEW

Secondary metabolites are chemical found in plants. These have no role in plant growth but these are important for human because it have many pharmacological activity. Bergenia species such as Bergenia stracheyi, Bergenia ligulata And Bergenia ligulata etc. have many secondary metabolites such as 1. Bergenin 2. Tannic acid 3. Gallic acid 4. Stigmesterol 5. β-Sitosterol 6. catechin 7. (+)-Afzelechin 8. 1,8-cineole 9. Isovalaric acid 10. (+)(6S)-parasorbic acid 11. Arbutin 12. Phytol 13. Caryophyllene 14. Damascenone 15. β-eudesmol 16. 3-methyl-2-buten-1-ol 17. (Z)-asarone 18. Terpinen-4-ol 19. Paashaanolactone which are medicinally important.

[1]  R. Merlanti,et al.  Excretion profile of boldenone in urine of veal calves fed two different milk replacers. , 2007, Analytica chimica acta.

[2]  U. Sonnemann,et al.  Therapy for Acute Nonpurulent Rhinosinusitis With Cineole: Results of a Double‐Blind, Randomized, Placebo‐Controlled Trial , 2004, The Laryngoscope.

[3]  J. H. Thorngate,et al.  Oral sensations associated with the flavan-3-ols (+)-catechin and (-)-epicatechin 1 Journal Series P , 1999 .

[4]  S. R. Smedley,et al.  Bombardier Beetles and Fever Trees: A Close-up Look at Chemical Warfare and Signals in Animals and Plants , 1995 .

[5]  R. Merlanti,et al.  Boldenone, boldione, and milk replacers in the diet of veal calves: the effects of phytosterol content on the urinary excretion of boldenone metabolites. , 2007, Journal of agricultural and food chemistry.

[6]  P. Thompson,et al.  Phytosterols and vascular disease. , 2006, Current opinion in lipidology.

[7]  Y. Kimura,et al.  Norepinephrine-augmenting lipolytic effectors from Astilbe thunbergii rhizomes. , 1998, Journal of natural products.

[8]  L. Vlase,et al.  Natural Resources Containing Arbutin. Determination of Arbutin in the Leaves of Bergenia crassifolia (L.) Fritsch. acclimated in Romania , 2009 .

[9]  C. Ghelardini,et al.  Local anaesthetic activity of beta-caryophyllene. , 2001, Farmaco.

[10]  Swapnil Sharma,et al.  POLYPHARMACOLOGICAL ACTIVITIES OF BERGENIA SPECIES Review Article , 2012 .

[11]  Raymond E. Kirk,et al.  Encyclopedia of chemical technology , 1998 .

[12]  A. Awad,et al.  Phytosterols as anticancer dietary components: evidence and mechanism of action. , 2000, The Journal of nutrition.

[13]  Richard Karban,et al.  Induced Responses to Herbivory , 1997 .

[14]  C. Djerassi,et al.  A convenient synthesis of progesterone from stigmasterol. , 1977, The Journal of organic chemistry.

[15]  Yue-xin Yang,et al.  Contents of phytosterols in vegetables and fruits commonly consumed in China. , 2008, Biomedical and environmental sciences : BES.

[16]  M. Cordeiro,et al.  Phenolic acid derivatives with potential anticancer properties--a structure-activity relationship study. Part 1: methyl, propyl and octyl esters of caffeic and gallic acids. , 2004, Bioorganic & medicinal chemistry.

[17]  K. Mahadik,et al.  Simultaneous quantification of bergenin, catechin, and gallic acid from Bergenia ciliata and Bergenia ligulata by using thin-layer chromatography , 2008 .

[18]  M. Hajaligol,et al.  Sublimation Thermodynamic Parameters for Cholesterol, Ergosterol, β-Sitosterol, and Stigmasterol , 2009 .

[19]  G. Assmann,et al.  Plasma sitosterol elevations are associated with an increased incidence of coronary events in men: results of a nested case-control analysis of the Prospective Cardiovascular Münster (PROCAM) study. , 2006, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[20]  N. Prager,et al.  A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. , 2002, Journal of alternative and complementary medicine.

[21]  T. Senge,et al.  Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. , 1995, Lancet.

[22]  A. S. Hamzah,et al.  Malaysianol A, a new trimer resveratrol oligomer from the stem bark of Dryobalanops aromatica. , 2011, Fitoterapia.

[23]  Takuya Suzuki,et al.  Alpha-glucosidase inhibitor from Bergenia ligulata. , 2008, Journal of oleo science.

[24]  Nighat Nazir,et al.  Immunomodulatory effect of bergenin and norbergenin against adjuvant-induced arthritis--a flow cytometric study. , 2007, Journal of ethnopharmacology.

[25]  A. Imberty,et al.  Investigation of the complexation of (+)-catechin by ?-cyclodextrin by a combination of NMR, microcalorimetry and molecular modeling techniquesElectronic supplementary information (ESI) available: NMR spectra. See http://www.rsc.org/suppdata/ob/b3/b302935m/ , 2003 .

[26]  A. Tiwari,et al.  Synthesis and antiglycation potentials of bergenin derivatives. , 2011, Bioorganic & medicinal chemistry letters.

[27]  T. Senge,et al.  Randomised, placebo-controlled, double-blind clinical trial of β-sitosterol in patients with benign prostatic hyperplasia , 1995, The Lancet.

[28]  Keisuke Matsuoka,et al.  Study of thermodynamic parameters for solubilization of plant sterol and stanol in bile salt micelles. , 2008, Chemistry and physics of lipids.

[29]  Xinhua Lin,et al.  Electrochemical study of bergenin on a poly(4-(2-pyridylazo)-resorcinol) modified glassy carbon electrode and its determination in tablets and urine. , 2007, Talanta.

[30]  A. Imberty,et al.  Investigation of the complexation of (+)-catechin by beta-cyclodextrin by a combination of NMR, microcalorimetry and molecular modeling techniques. , 2003, Organic & biomolecular chemistry.

[31]  Xiaojie Xu,et al.  In Vitro Anti-HCV Activities of Saxifraga Melanocentra and its Related Polyphenolic Compounds , 2005, Antiviral chemistry & chemotherapy.

[32]  R. Chauhan,et al.  BERGENIA CILIATA MINE OF MEDICINAL PROPERTIES: A REVIEW , 2012 .

[33]  W. Lorenz,et al.  Histamine and acute haemorrhagic lesions in rat gastric mucosa: Prevention of stress ulcer formation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro , 1977, Agents and Actions.

[34]  K. Priyadarsini,et al.  Reactions of hydroxyl radical with bergenin, a natural poly phenol studied by pulse radiolysis. , 2009, Bioorganic & medicinal chemistry.

[35]  R. Payne,et al.  The Synthesis of Naturally Occurring Vitamin K and Vitamin K Analogues , 2003 .

[36]  S. Omaye,et al.  Phytochemicals as bioactive agents , 2000 .

[37]  A. Gillissen,et al.  Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes. , 2004, Pulmonary pharmacology & therapeutics.

[38]  A. Gillissen,et al.  Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial. , 2003, Respiratory medicine.

[39]  J. Dwivedi,et al.  PASHANBHEDA A GOLDEN HERB OF HIMALAYA: A REVIEW , 2012 .

[40]  A. S. Chawla,et al.  High pressure liquid chromatographic determination of bergenin and (+)-afzelechin from different parts of Paashaanbhed (Bergenia ligulata Yeo) , 1999 .

[41]  K. Suk,et al.  Anti-inflammatory effects of catechols in lipopolysaccharide-stimulated microglia cells: inhibition of microglial neurotoxicity. , 2008, European journal of pharmacology.

[42]  H. Vetter,et al.  Inhibition of cytokine production and arachidonic acid metabolism by eucalyptol (1.8-cineole) in human blood monocytes in vitro. , 1998, European journal of medical research.

[43]  J. Harborne,et al.  Chemical dictionary of economic plants , 2001 .

[44]  Takuya Suzuki,et al.  Insecticidal effect and chemical composition of the volatile oil from Bergenia ligulata. , 2011, Journal of agricultural and food chemistry.

[45]  K. B. Hicks,et al.  Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and health-promoting uses. , 2002, Progress in lipid research.

[46]  R. Wanders,et al.  Phytanic acid: production from phytol, its breakdown and role in human disease , 2006, Cellular and Molecular Life Sciences.

[47]  Mei-Hsien Lee,et al.  Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla. , 2005, Journal of ethnopharmacology.

[48]  S. Nath,et al.  Catechins protect neurons against mitochondrial toxins and HIV proteins via activation of the BDNF pathway , 2012, Journal of NeuroVirology.

[49]  A. S. Chawla,et al.  Paashaanolactone from Bergenia ligulata , 1998 .

[50]  A. Kar,et al.  Thyroid inhibitory, antiperoxidative and hypoglycemic effects of stigmasterol isolated from Butea monosperma. , 2009, Fitoterapia.

[51]  F. Berenbaum,et al.  Stigmasterol: a phytosterol with potential anti-osteoarthritic properties. , 2010, Osteoarthritis and cartilage.

[52]  C. Ghelardini,et al.  Local anaesthetic activity of β-caryophyllene ☆ , 2001 .

[53]  A. Stalenhoef,et al.  Phytosterol consumption and the anabolic steroid boldenone in humans: A hypothesis piloted , 2007, Food additives and contaminants.

[54]  Ying-Jun Zhang,et al.  A carbon-carbon-coupled dimeric bergenin derivative biotransformed by Pleurotus ostreatus. , 2005, Bioorganic & medicinal chemistry letters.

[55]  .. Z.Charrouf,et al.  Phenols and Polyphenols from Argania spinosa , 2007 .

[56]  A. House,et al.  Eucalyptus Leaf Oils Use Chemistry Distillation and Marketing , 1991 .

[57]  G. Perkins,et al.  (–)‐Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle , 2011, The Journal of physiology.

[58]  M. Eadie Could Valerian Have Been the First Anticonvulsant? , 2004, Epilepsia.

[59]  A. Kinghorn,et al.  Flavonoids and a proanthocyanidin from rhizomes of Selliguea feei , 1994 .

[60]  S. Mertens-Talcott,et al.  Chemical composition, antioxidant properties, and thermal stability of a phytochemical enriched oil from Acai (Euterpe oleracea Mart.). , 2008, Journal of agricultural and food chemistry.

[61]  M. Berenbaum,et al.  Herbivores: their interactions with secondary plant metabolites. Volume 1: The chemical participants. , 1991 .

[62]  Y. Zhong,et al.  Chemical composition of the volatiles of three wild Bergenia species from western China , 2006 .

[63]  T. Okuda,et al.  Carbonic anhydrase inhibitors from the pericarps of Punica granatum L. , 1993, Biological & pharmaceutical bulletin.