Pilot study of computerised differentiation of Huntington's disease, schizophrenic, and parkinson's disease patients using the contingent negative variation

In this study a potential known as the contingent negative variation was used to differentiate between schizophrenic, Parkinson's disease (PD), Huntington's disease (HD) patients and normal control subjects. The aim was to assist diagnosis and the avoidance of false diagnosis. 20 schizophrenic, 16 PD, 11 HD and 43 normal control subjects were enrolled for this study. The discriminatory variables were generated by applying spectral analysis to pre- and post-stimulus sections of the CNV responses. The patient differentiation was achieved by using the measured variables in a discriminant analysis program. It was possible to accurately differentiate between HD, schizophrenic, PD patients and normal control subjects. It was also attempted to differentiate between HD and schizophrenic patients, HD and PD patients, and schizophrenic and PD patients. The test results indicated that the method is useful in differentiating between these patients. This study had a number of limitations. It was based on a limited number of individuals, and an analysis of medication effects on the test results and the test-retest reliability assessment could not be carried out.

[1]  J. Parkinson.  An Essay on the Shaking Palsy , 2002 .

[2]  W. Walter,et al.  Contingent Negative Variation : An Electric Sign of Sensori-Motor Association and Expectancy in the Human Brain , 1964, Nature.

[3]  S. Shapiro,et al.  An Analysis of Variance Test for Normality (Complete Samples) , 1965 .

[4]  W G Walter,et al.  The contingent negative variation in cases of known brain lesions. , 1970, Electroencephalography and clinical neurophysiology.

[5]  J. Tecce.  Contingent negative variation (CNV) and psychological processes in man. , 1972, Psychological bulletin.

[6]  Kanti V. Mardia,et al.  Statistics of Directional Data , 1972 .

[7]  J. Cohen.  Chapter 7 – Cerebral Psychophysiology: The Contingent Negative Variation , 1974 .

[8]  D B Lindsley,et al.  Brain wave components of the contingent negative variation in humans. , 1976, Science.

[9]  W. Roth.  Late event-related potentials and psychopathology. , 1977, Schizophrenia bulletin.

[10]  C. Finch,et al.  Parkinson’s Disease—II , 1978, Advances in Experimental Medicine and Biology.

[11]  C. K. Yuen,et al.  Theory and Application of Digital Signal Processing , 1978, IEEE Transactions on Systems, Man, and Cybernetics.

[12]  F. Harris.  On the use of windows for harmonic analysis with the discrete Fourier transform , 1978, Proceedings of the IEEE.

[13]  Henry Stark,et al.  Modern Electrical Communications: Theory and Systems , 1979 .

[14]  M. Hayden,et al.  Huntington’s Chorea , 1981, Springer London.

[15]  Barrie W. Jervis,et al.  A Fundamental Investigation of the Composition of Auditory Evoked Potentials , 1983, IEEE Transactions on Biomedical Engineering.

[16]  D. Weinberger,et al.  Neuropathological studies of schizophrenia: a selective review. , 1983, Schizophrenia bulletin.

[17]  A. Young,et al.  A polymorphic DNA marker genetically linked to Huntington's disease , 1983, Nature.

[18]  Nigel R. Hudson,et al.  The Application of Pattern Recognition Techniques to the Contingent Negative Variation for the Differentiation of Subject Categories , 1984, IEEE Transactions on Biomedical Engineering.

[19]  M. Reveley,et al.  CT Scans in Schizophrenia , 1985, British Journal of Psychiatry.

[20]  A Predictive Test for Huntington's Disease: Recombinant DNA Technology and Implications for Nursing , 1987, The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses.

[21]  S. Youngman,et al.  Huntington's disease: prediction and prevention. , 1988, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[22]  Genetic prediction in Huntington's disease: What are the limitations imposed by pedigree structure , 1988, Movement disorders : official journal of the Movement Disorder Society.

[23]  P. Abraham.  Two measures of mental illness: contingent negative variation and spiral after-effect. , 1989, Comparative biochemistry and physiology. A, Comparative physiology.

[24]  J. Mazziotta.  Huntington's Disease: Studies with Structural Imaging Techniques and Positron Emission Tomography , 1989, Seminars in neurology.

[25]  M. Ron,et al.  The brain in schizophrenia. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[26]  Daniel J. Luchins,et al.  Relationship between Brain Imaging Findings in Schizophrenia and Psychopathology , 1990 .

[27]  W. Weiner,et al.  The comprehensive management of Parkinson's disease , 1994 .

[28]  The Comprehensive Management of Parkinson's Disease , 1995 .

[29]  Allan H. Ropper,et al.  Evoked potentials in clinical medicine (second of two parts). , 1982 .

[30]  B. Bogerts,et al.  Cell loss in the hippocampus of schizophrenics , 2004, European archives of psychiatry and neurological sciences.

[31]  Houeto Jean-Luc.  [Parkinson's disease]. , 2022, La Revue du praticien.

[32]  B. W. Jervis,et al.  Effect on EEG responses of removing ocular artefacts by proportional EOG subtraction , 2006, Medical and Biological Engineering and Computing.

[33]  B. W. Jervis,et al.  Spectral analysis of EEG responses , 1989, Medical and Biological Engineering and Computing.