Regulation of muscle mass by growth hormone and IGF‐I

[1]  C. Ward,et al.  A functional insulin‐like growth factor receptor is not necessary for load‐induced skeletal muscle hypertrophy , 2008, The Journal of physiology.

[2]  A. Goldberg,et al.  FoxO3 controls autophagy in skeletal muscle in vivo. , 2007, Cell metabolism.

[3]  J. Baker,et al.  Short-term recombinant human growth hormone administration improves respiratory function in abstinent anabolic-androgenic steroid users. , 2007, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[4]  J. Wit,et al.  Genetic disorders in the GH IGF-I axis in mouse and man. , 2007, European journal of endocrinology.

[5]  N. Goldenberg,et al.  Factors regulating growth hormone secretion in humans. , 2007, Endocrinology and metabolism clinics of North America.

[6]  G. Butler-Browne,et al.  IL-13 mediates the recruitment of reserve cells for fusion during IGF-1-induced hypertrophy of human myotubes , 2007, Journal of Cell Science.

[7]  E. Barton,et al.  The ABCs of IGF-I isoforms: impact on muscle hypertrophy and implications for repair. , 2006, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[8]  S. Bodine,et al.  Resistance exercise, muscle loading/unloading and the control of muscle mass. , 2006, Essays in biochemistry.

[9]  Z. Yablonka-Reuveni,et al.  The Skeletal Muscle Satellite Cell: The Stem Cell That Came in From the Cold , 2006, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[10]  T. Shavlakadze,et al.  Of bears, frogs, meat, mice and men: complexity of factors affecting skeletal muscle mass and fat , 2006, BioEssays : news and reviews in molecular, cellular and developmental biology.

[11]  L. Metherell,et al.  Endocrine assessment, molecular characterization and treatment of growth hormone insensitivity disorders , 2006, Nature Clinical Practice Endocrinology &Metabolism.

[12]  L. Avois,et al.  Human growth hormone doping in sport , 2006, British Journal of Sports Medicine.

[13]  L. Gormsen,et al.  GH receptor signaling in skeletal muscle and adipose tissue in human subjects following exposure to an intravenous GH bolus. , 2006, American journal of physiology. Endocrinology and metabolism.

[14]  J. M. Boswell,et al.  Rskα-actin/hIGF-1 transgenic mice with increased IGF-I in skeletal muscle and blood: Impact on regeneration, denervation and muscular dystrophy , 2006 .

[15]  P. Kelly,et al.  Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[16]  S. Ezzat,et al.  The influence of growth hormone status on physical impairments, functional limitations, and health-related quality of life in adults. , 2006, Endocrine reviews.

[17]  M. Vance,et al.  Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline. , 2006, The Journal of clinical endocrinology and metabolism.

[18]  F. Martin,et al.  The effects of growth hormone and/or testosterone in healthy elderly men: a randomized controlled trial. , 2006, The Journal of clinical endocrinology and metabolism.

[19]  M. Sheppard,et al.  Growth hormone and its disorders , 2006, Postgraduate Medical Journal.

[20]  David J. Kosek,et al.  Resting and load-induced levels of myogenic gene transcripts differ between older adults with demonstrable sarcopenia and young men and women. , 2005, Journal of applied physiology.

[21]  D. Glass,et al.  Skeletal muscle hypertrophy and atrophy signaling pathways. , 2005, The international journal of biochemistry & cell biology.

[22]  A. Sartorio,et al.  Growth hormone abuse: methods of detection , 2005, Trends in Endocrinology & Metabolism.

[23]  D. Leroith,et al.  Intact insulin and insulin-like growth factor-I receptor signaling is required for growth hormone effects on skeletal muscle growth and function in vivo. , 2005, Endocrinology.

[24]  P. Sönksen,et al.  Toward the development of a test for growth hormone (GH) abuse: a study of extreme physiological ranges of GH-dependent markers in 813 elite athletes in the postcompetition setting. , 2005, The Journal of clinical endocrinology and metabolism.

[25]  N. Mauras,et al.  Are the metabolic effects of GH and IGF-I separable? , 2005, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[26]  N. Rosenthal,et al.  Reconciling data from transgenic mice that overexpress IGF-I specifically in skeletal muscle. , 2005, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[27]  A. Bigot,et al.  IGF-1 induces human myotube hypertrophy by increasing cell recruitment. , 2004, Experimental Cell Research.

[28]  G. Yancopoulos,et al.  The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. , 2004, Molecular cell.

[29]  D. Bolster,et al.  Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling , 2004, The Proceedings of the Nutrition Society.

[30]  P. Yin,et al.  Evidence That IGF Binding Protein-5 Functions as a Ligand-Independent Transcriptional Regulator in Vascular Smooth Muscle Cells , 2004, Circulation research.

[31]  F. Booth,et al.  Control of the size of the human muscle mass. , 2004, Annual review of physiology.

[32]  H. Sweeney,et al.  Viral expression of insulin-like growth factor-I enhances muscle hypertrophy in resistance-trained rats. , 2004, Journal of applied physiology.

[33]  M. Kjaer,et al.  The effect of recombinant human growth hormone and resistance training on IGF‐I mRNA expression in the muscles of elderly men , 2004, The Journal of physiology.

[34]  A. Umpleby,et al.  High dose growth hormone exerts an anabolic effect at rest and during exercise in endurance-trained athletes. , 2003, The Journal of clinical endocrinology and metabolism.

[35]  M. Rennie.  Claims for the anabolic effects of growth hormone: a case of the Emperor’s new clothes? , 2003, British journal of sports medicine.

[36]  Richard W. Orrell,et al.  Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise.[see comment] , 2003 .

[37]  R W Orrell,et al.  Expression of IGF‐I splice variants in young and old human skeletal muscle after high resistance exercise , 2003, The Journal of physiology.

[38]  A. Belfiore,et al.  Insulin/Insulin-like Growth Factor I Hybrid Receptors Have Different Biological Characteristics Depending on the Insulin Receptor Isoform Involved* , 2002, The Journal of Biological Chemistry.

[39]  D. Bolster,et al.  AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling* , 2002, The Journal of Biological Chemistry.

[40]  E. Kajantie,et al.  IGF-I, IGF binding protein (IGFBP)-3, phosphoisoforms of IGFBP-1, and postnatal growth in very low birth weight infants. , 2002, The Journal of clinical endocrinology and metabolism.

[41]  C. Lang,et al.  Regulation of IGF-I mRNA and signal transducers and activators of transcription-3 and -5 (Stat-3 and -5) by GH in C2C12 myoblasts. , 2002, Endocrinology.

[42]  J. Bülow,et al.  GH administration changes myosin heavy chain isoforms in skeletal muscle but does not augment muscle strength or hypertrophy, either alone or combined with resistance exercise training in healthy elderly men. , 2002, The Journal of clinical endocrinology and metabolism.

[43]  C. Rommel,et al.  Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways , 2001, Nature Cell Biology.

[44]  J. Guevara-Aguirre,et al.  The IGF-I generation test revisited: a marker of GH sensitivity. , 2001, The Journal of clinical endocrinology and metabolism.

[45]  D. Kiel,et al.  Growth Hormone Administration and Exercise Effects on Muscle Fiber Type and Diameter in Moderately Frail Older People , 2001, Journal of the American Geriatrics Society.

[46]  J. Yesavage,et al.  One year of insulin-like growth factor I treatment does not affect bone density, body composition, or psychological measures in postmenopausal women. , 2001, The Journal of clinical endocrinology and metabolism.

[47]  G R Hunter,et al.  Mechanical load increases muscle IGF-I and androgen receptor mRNA concentrations in humans. , 2001, American journal of physiology. Endocrinology and metabolism.

[48]  Antonio Musarò,et al.  Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle , 2001, Nature Genetics.

[49]  S. Yakar,et al.  The somatomedin hypothesis: 2001. , 2001, Endocrine reviews.

[50]  M. Nakazato,et al.  Ghrelin is a growth-hormone-releasing acylated peptide from stomach , 1999, Nature.

[51]  V R Edgerton,et al.  Modulation of myonuclear number in functionally overloaded and exercised rat plantaris fibers. , 1999, Journal of applied physiology.

[52]  F. Kadi,et al.  Training affects myosin heavy chain phenotype in the trapezius muscle of women , 1999, Histochemistry and Cell Biology.

[53]  J. Kehayias,et al.  Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. , 1999, American journal of physiology. Endocrinology and metabolism.

[54]  D. Leroith,et al.  Normal growth and development in the absence of hepatic insulin-like growth factor I. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[55]  K. Sjögren,et al.  Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[56]  D. Chinkes,et al.  Muscle protein catabolism after severe burn: effects of IGF-1/IGFBP-3 treatment. , 1999, Annals of surgery.

[57]  L. Shantz,et al.  Leucine Regulates Translation of Specific mRNAs in L6 Myoblasts through mTOR-mediated Changes in Availability of eIF4E and Phosphorylation of Ribosomal Protein S6* , 1999, The Journal of Biological Chemistry.

[58]  D. Clemmons,et al.  Binding of insulin-like growth factor (IGF)-binding protein-5 to smooth-muscle cell extracellular matrix is a major determinant of the cellular response to IGF-I. , 1998, Molecular biology of the cell.

[59]  G. Adams,et al.  Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats. , 1998, Journal of applied physiology.

[60]  T. Wagner,et al.  A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[61]  B. Saltin,et al.  Net Fluxes Over Working Thigh of Hormones, Growth Factors and Biomarkers of Bone Metabolism During Short Lasting Dynamic Exercise , 1997, Calcified Tissue International.

[62]  F. Haddad,et al.  The relationships among IGF-1, DNA content, and protein accumulation during skeletal muscle hypertrophy. , 1996, Journal of applied physiology.

[63]  M. Kendall,et al.  Growth hormone treatment for growth hormone deficient adults , 1996, Journal of clinical pharmacy and therapeutics.

[64]  S. Welle,et al.  Growth hormone increases muscle mass and strength but does not rejuvenate myofibrillar protein synthesis in healthy subjects over 60 years old. , 1996, The Journal of clinical endocrinology and metabolism.

[65]  D. Meyer,et al.  The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH. , 1996, Molecular endocrinology.

[66]  E. Barrett,et al.  Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. , 1995, The Journal of clinical investigation.

[67]  Robert J. Schwartz,et al.  Myogenic Vector Expression of Insulin-like Growth Factor I Stimulates Muscle Cell Differentiation and Myofiber Hypertrophy in Transgenic Mice (*) , 1995, The Journal of Biological Chemistry.

[68]  K. Yarasheski,et al.  Effect of growth hormone and resistance exercise on muscle growth and strength in older men. , 1995, The American journal of physiology.

[69]  E. Froesch,et al.  Expression and regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein messenger ribonucleic acid levels in tissues of hypophysectomized rats infused with IGF-I and growth hormone. , 1994, Endocrinology.

[70]  T. Yagi,et al.  Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 , 1994, Nature.

[71]  C. Kahn,et al.  Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene , 1994, Nature.

[72]  R L Hintz,et al.  Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. , 1994, The Journal of clinical endocrinology and metabolism.

[73]  A. Barkan,et al.  Negative feedback regulation of pulsatile growth hormone secretion by insulin-like growth factor I. Involvement of hypothalamic somatostatin. , 1994, The Journal of clinical investigation.

[74]  P. Bechtel,et al.  Modulation of IGF mRNA abundance during stretch-induced skeletal muscle hypertrophy and regression. , 1994, Journal of applied physiology.

[75]  M. Preece,et al.  Clinical features and endocrine status in patients with growth hormone insensitivity (Laron syndrome). , 1993, The Journal of clinical endocrinology and metabolism.

[76]  L. Powell-Braxton,et al.  IGF-I is required for normal embryonic growth in mice. , 1993, Genes & development.

[77]  D. Clemmons,et al.  Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[78]  J. Baker,et al.  Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r) , 1993, Cell.

[79]  Elizabeth J. Robertson,et al.  Role of insulin-like growth factors in embryonic and postnatal growth , 1993, Cell.

[80]  W. Gonyea,et al.  Progressive stretch overload of skeletal muscle results in hypertrophy before hyperplasia. , 1993, Journal of applied physiology.

[81]  E. Barrett,et al.  Growth hormone acutely stimulates skeletal muscle but not whole-body protein synthesis in humans. , 1993, Metabolism: clinical and experimental.

[82]  K. Yarasheski,et al.  Short-term growth hormone treatment does not increase muscle protein synthesis in experienced weight lifters. , 1993, Journal of applied physiology.

[83]  M. Rechler,et al.  Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6. , 1993, The Journal of biological chemistry.

[84]  W. Blum,et al.  Effect of growth hormone treatment on hormonal parameters, body composition and strength in athletes. , 1993, Acta endocrinologica.

[85]  R. Baxter,et al.  Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously. , 1993, The Journal of clinical investigation.

[86]  J. Rosenblatt,et al.  Gamma irradiation prevents compensatory hypertrophy of overloaded mouse extensor digitorum longus muscle. , 1992, Journal of applied physiology.

[87]  G. Norstedt,et al.  Activation of insulin-like growth factor II expression during skeletal muscle regeneration in the rat: correlation with myotube formation. , 1992, Molecular endocrinology.

[88]  D. Clemmons,et al.  Reversal of diet-induced catabolism by infusion of recombinant insulin-like growth factor-I in humans. , 1992, The Journal of clinical endocrinology and metabolism.

[89]  K. Yarasheski,et al.  Effect of growth hormone and resistance exercise on muscle growth in young men. , 1992, The American journal of physiology.

[90]  E. Schoenle,et al.  Recombinant human insulin-like growth factor I (rhIGF I) reduces hyperglycaemia in patients with extreme insulin resistance , 1991, Diabetologia.

[91]  N. Møłler,et al.  The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[92]  E. Barrett,et al.  Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans. , 1991, The American journal of physiology.

[93]  H. Vandenburgh,et al.  Insulin and IGF-I induce pronounced hypertrophy of skeletal myofibers in tissue culture. , 1991, The American journal of physiology.

[94]  C. Wiles,et al.  Growth hormone treatment in growth hormone-deficient adults. I. Effects on muscle mass and strength. , 1991, Journal of applied physiology.

[95]  R. Palmiter,et al.  Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone-deficient transgenic mice. , 1990, Endocrinology.

[96]  D. Rudman,et al.  Effects of human growth hormone in men over 60 years old. , 1990, The New England journal of medicine.

[97]  P. Bechtel,et al.  Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth. , 1990, The American journal of physiology.

[98]  R. Palmiter,et al.  Growth enhancement of transgenic mice expressing human insulin-like growth factor I. , 1988, Endocrinology.

[99]  M. Rennie,et al.  PREVENTION OF DISUSE MUSCLE ATROPHY BY MEANS OF ELECTRICAL STIMULATION: MAINTENANCE OF PROTEIN SYNTHESIS , 1988, The Lancet.

[100]  G. Dudley,et al.  Histochemical Characteristics of Soleus Muscle in hGH Transgenic Mice , 1987, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[101]  R. Palmiter,et al.  Regulation of insulin-like growth factor I gene expression by growth hormone. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[102]  S. M. Russell,et al.  Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[103]  A. Stiles,et al.  Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[104]  J. Jansson,et al.  Growth hormone stimulates longitudinal bone growth directly. , 1982, Science.

[105]  R L Hintz,et al.  Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. , 1981, Science.

[106]  M. Davies,et al.  Muscle changes in acromegaly. , 1976, British medical journal.

[107]  P. Henneman,et al.  Effects of human growth hormone in man. , 1960, The Journal of clinical investigation.

[108]  P. Sönksen,et al.  The growth hormone/insulin-like growth factor-I axis in exercise and sport. , 2007, Endocrine reviews.

[109]  J. M. Boswell,et al.  Rskalpha-actin/hIGF-1 transgenic mice with increased IGF-I in skeletal muscle and blood: impact on regeneration, denervation and muscular dystrophy. , 2006, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[110]  S. Harridge,et al.  Two weeks of GH administration does not increase the expression of insulin-like growth factor-I mRNA splice variants in the skeletal muscles of young men , 2004 .

[111]  J. Terwilliger,et al.  Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. , 2001, Developmental biology.

[112]  J. Kopchick,et al.  Transgenic models of growth hormone action. , 1999, Annual review of nutrition.

[113]  A. Efstratiadis.  Genetics of mouse growth. , 1998, The International journal of developmental biology.

[114]  R. Marcus,et al.  Effect of rhGH and rhIGF-I treatment on protein utilization in elderly women. , 1997, The American journal of physiology.

[115]  Andrew,et al.  Lack of effect of recombinant human growth hormone (GH) on muscle morphology and GH-insulin-like growth factor expression in resistance-trained elderly men. , 1996, The Journal of clinical endocrinology and metabolism.

[116]  M. Preece,et al.  Clinical Features and Endocrine Status in Patients with Growth Hormone Insensitivity , 1993 .

[117]  C. Wiles,et al.  Histology of skeletal muscle in adults with GH deficiency: comparison with normal muscle and response to GH treatment. , 1992, Hormone research.

[118]  D. Rudman,et al.  Effects of human growth hormone on body composition in elderly men. , 1991, Hormone research.

[119]  Obert,et al.  Effects of human growth hormone in men over 60 years old. , 1990, The New England journal of medicine.

[120]  N. Stickland.  Muscle development in the human fetus as exemplified by m. sartorius: a quantitative study. , 1981, Journal of anatomy.

[121]  H. E. Jones,et al.  Letter: Splenectomy in acute lymphatic leukaemia. , 1975, Lancet.

[122]  G. Frick,et al.  Printed in U.S.A. Copyright © 1998 by The Endocrine Society Tissue Distribution, Turnover, and Glycosylation of the Long and Short Growth Hormone Receptor Isoforms in Rat Tissues* , 2022 .