The future of human gene therapy.
暂无分享,去创建一个
[1] M. Cipolla. Pathophysiology and clinical applications of nitric oxide , 2000 .
[2] R. Samulski,et al. Roles of Adeno-Associated Virus Rep Protein and Human Chromosome 19 in Site-Specific Recombination , 2000, Journal of Virology.
[3] V. Krasnykh,et al. Genetic targeting of adenoviral vectors. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.
[4] F. Deist,et al. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. , 2000, Science.
[5] M. Brenner. Reports of adenovector "death" are greatly exaggerated. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.
[6] Alan McClelland,et al. Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector , 2000, Nature Genetics.
[7] J. Isner,et al. Stem cell therapy and gene transfer for regeneration , 2000, Gene Therapy.
[8] P. Herrling,et al. Progress and potential for gene-based medicines. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.
[9] A. Giaccia,et al. Development of a hypoxia-responsive vector for tumor-specific gene therapy , 2000, Gene Therapy.
[10] B. Carter. Gene therapy as drug development. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.
[11] M. Lusky,et al. Modulation of the inflammatory properties and hepatotoxicity of recombinant adenovirus vectors by the viral E4 gene products. , 2000, Human gene therapy.
[12] L. Phillips,et al. Glucose regulated production of human insulin in rat hepatocytes , 2000, Gene Therapy.
[13] P. Boekstegers,et al. Myocardial gene transfer by selective pressure-regulated retroinfusion of coronary veins , 2000, Gene Therapy.
[14] S. Ylä-Herttuala,et al. Cardiovascular gene therapy , 2000, The Lancet.
[15] J. Pearlman,et al. Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: results of a phase I randomized, double-blind, placebo-controlled trial. , 1999, Circulation.
[16] J. Polak,et al. Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: the PREVENT single-centre, randomised, controlled trial , 1999, The Lancet.
[17] Sally Lehrman,et al. Virus treatment questioned after gene therapy death , 1999, Nature.
[18] W. Hancock,et al. Reversed-phase high-performance liquid chromatographic assay for the adenovirus type 5 proteome. , 1999, Journal of chromatography. B, Biomedical sciences and applications.
[19] J. Isner,et al. Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease. , 1999, The Annals of thoracic surgery.
[20] M. Post,et al. Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease. , 1999, Circulation.
[21] M. Balter. Support Builds for Allègre's Reforms , 1999, Science.
[22] I. Chen,et al. Lentiviral Vectors--the Promise of Gene Therapy Within Reach? , 1999, Science.
[23] A. Asai,et al. Highly augmented cytopathic effect of a fiber-mutant E1B-defective adenovirus for gene therapy of gliomas. , 1999, Cancer research.
[24] S. Kochanek,et al. Frequency and Stability of Chromosomal Integration of Adenovirus Vectors , 1999, Journal of Virology.
[25] G. Yancopoulos,et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. , 1999, Science.
[26] D. Cumberland,et al. Ultrasound enhances reporter gene expression after transfection of vascular cells in vitro. , 1999, Circulation.
[27] A. Thor,et al. Systemic Gene Delivery Expands the Repertoire of Effective Antiangiogenic Agents* , 1999, The Journal of Biological Chemistry.
[28] P. Kuppen,et al. Specific tumor-cell killing with adenovirus vectors containing the apoptin gene , 1999, Gene Therapy.
[29] M. Bureau,et al. High-efficiency gene transfer into skeletal muscle mediated by electric pulses. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[30] M A Konerding,et al. Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. , 1999, Circulation.
[31] Haruchika Masuda,et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization , 1999, Nature Medicine.
[32] G. Palù,et al. Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: a pilot study in humans , 1999, Gene Therapy.
[33] E. Svensson,et al. Efficient and stable transduction of cardiomyocytes after intramyocardial injection or intracoronary perfusion with recombinant adeno-associated virus vectors. , 1999, Circulation.
[34] M. Marcelli,et al. Signaling pathway activated during apoptosis of the prostate cancer cell line LNCaP: overexpression of caspase-7 as a new gene therapy strategy for prostate cancer. , 1999, Cancer research.
[35] P. Musiani,et al. Immune events associated with the cure of established tumors and spontaneous metastases by local and systemic interleukin 12. , 1999, Cancer research.
[36] G. Neufeld,et al. Vascular endothelial growth factor (VEGF) and its receptors , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[37] J. Isner,et al. Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia. , 1998, Circulation.
[38] J. Isner,et al. Direct intramuscular injection of plasmid DNA encoding angiopoietin-1 but not angiopoietin-2 augments revascularization in the rabbit ischemic hindlimb. , 1998, Circulation.
[39] H. Blau,et al. VEGF gene delivery to muscle: potential role for vasculogenesis in adults. , 1998, Molecular cell.
[40] D. Neuberg,et al. Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[41] R. Munford,et al. Physiologically responsive gene therapy. , 1998, Molecular medicine today.
[42] T. Liu,et al. Bystander effect in the adenovirus-mediated wild-type p53 gene therapy model of human squamous cell carcinoma of the head and neck. , 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.
[43] K. Channon. Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications , 1998 .
[44] N. Lemoine,et al. Targeting angiogenesis: genetic intervention which strikes at the weak link of tumorigenesis , 1998, Gene Therapy.
[45] P. Opolon,et al. Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice , 1998, Gene Therapy.
[46] Simon C Watkins,et al. Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells. , 1998, Circulation.
[47] M. Aoki,et al. Inhibition of intimal hyperplasia after vein grafting by in vivo transfer of human senescent cell-derived inhibitor-1 gene , 1998, Gene Therapy.
[48] J D Pearlman,et al. Therapeutic angiogenesis with basic fibroblast growth factor: technique and early results. , 1998, The Annals of thoracic surgery.
[49] L. Ellis,et al. Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer. , 1998, Cancer research.
[50] J. Isner,et al. Mouse model of angiogenesis. , 1998, The American journal of pathology.
[51] K Walsh,et al. Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. , 1998, Circulation.
[52] R. Steinman,et al. Dendritic cells and the control of immunity , 1998, Nature.
[53] P. Huang,et al. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. , 1998, The Journal of clinical investigation.
[54] B. V. von Specht,et al. Induction of neoangiogenesis in ischemic myocardium by human growth factors: first clinical results of a new treatment of coronary heart disease. , 1998, Circulation.
[55] E. Nabel,et al. Expression of cyclin-dependent kinase inhibitors in vascular disease. , 1998, Circulation research.
[56] K. March,et al. Gene therapy for restenosis: getting nearer the heart of the matter. , 1998, Circulation research.
[57] D. Dichek,et al. Gene therapy for restenosis: are we ready? , 1998, Circulation research.
[58] Y. Kaneda,et al. Transfer of wild-type p53 gene effectively inhibits vascular smooth muscle cell proliferation in vitro and in vivo. , 1998, Circulation research.
[59] T. Libermann,et al. Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[60] W. Schaper,et al. The delivery of angiogenic factors to the heart by microsphere therapy , 1998, Nature Biotechnology.
[61] Jennifer L Hall,et al. Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease , 1998, Nature Medicine.
[62] R. Vile,et al. Strategies for achieving multiple layers of selectivity in gene therapy. , 1998, Molecular medicine today.
[63] E. Chau,et al. Large Unruptured Aneurysm in Sinus of Valsalva , 1998 .
[64] I. Zachary,et al. Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen‐activated protein kinase , 1997, FEBS letters.
[65] A. Melcher,et al. Personal paper: Gene therapy for cancer—managing expectations , 1997, BMJ.
[66] Shannon R. Magari,et al. Pharmacologic control of a humanized gene therapy system implanted into nude mice. , 1997, The Journal of clinical investigation.
[67] D. Brough,et al. Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins , 1997, Journal of virology.
[68] I. Verma,et al. Gene therapy - promises, problems and prospects , 1997, Nature.
[69] T. Clackson. Controlling mammalian gene expression with small molecules. , 1997, Current opinion in chemical biology.
[70] T. Ogihara,et al. In vivo transfection of cis element “decoy” against nuclear factor- κB binding site prevents myocardial infarction , 1997, Nature Medicine.
[71] R. Crystal,et al. Inhibition of vascular smooth muscle cell proliferation and neointimal accumulation by adenovirus-mediated gene transfer of cytosine deaminase. , 1997, Circulation.
[72] D. Kirn,et al. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents , 1997, Nature Medicine.
[73] S. Ylä-Herttuala. Vascular gene transfer. , 1997, Current opinion in lipidology.
[74] H. Matsuzaki,et al. Hematopoietic stem cell-based gene therapy for acquired immunodeficiency syndrome: efficient transduction and expression of RevM10 in myeloid cells in vivo and in vitro. , 1997, Blood.
[75] J. Bergelson,et al. Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5 , 1997, Science.
[76] J. Isner,et al. Vascular endothelial growth factor/vascular permeability factor augments nitric oxide release from quiescent rabbit and human vascular endothelium. , 1997, Circulation.
[77] S. Morrison,et al. Design and production of novel tetravalent bispecific antibodies , 1997, Nature Biotechnology.
[78] A. Belldegrun,et al. Identification of a positive regulatory element responsible for tissue-specific expression of prostate-specific antigen. , 1997, Cancer research.
[79] J. Isner,et al. Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion. , 1996, Circulation.
[80] D. Brough,et al. Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types , 1996, Nature Biotechnology.
[81] D. Curiel,et al. Targeted gene delivery by tropism-modified adenoviral vectors , 1996, Nature Biotechnology.
[82] A. Fattaey,et al. An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells , 1996, Science.
[83] G. Karsenty,et al. Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models. , 1996, Cancer research.
[84] E. Nabel,et al. A new cationic liposome DNA complex enhances the efficiency of arterial gene transfer in vivo. , 1996, Human gene therapy.
[85] Shannon R. Magari,et al. A humanized system for pharmacologic control of gene expression , 1996, Nature Medicine.
[86] S. Schreiber,et al. Dimeric ligands define a role for transcriptional activation domains in reinitiation , 1996, Nature.
[87] Takayuki Asahara,et al. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb , 1996, The Lancet.
[88] K. Mechtler,et al. Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. , 1996, Human gene therapy.
[89] E. Nabel,et al. Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[90] G. Gibbons,et al. Molecular Therapies for Vascular Diseases , 1996, Science.
[91] J. Wilson,et al. Adenoviruses as gene-delivery vehicles. , 1996, The New England journal of medicine.
[92] Peipei Ping,et al. Intracoronary gene transfer of fibroblast growth factor–5 increases blood flow and contractile function in an ischemic region of the heart , 1996, Nature Medicine.
[93] J. Leiden,et al. Immune responses to transgene–encoded proteins limit the stability of gene expression after injection of replication–defective adenovirus vectors , 1996, Nature Medicine.
[94] R. Evans,et al. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[95] J. Folkman. Clinical Applications of Research on Angiogenesis , 1995 .
[96] J. Leiden,et al. Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty. , 1995, The Journal of clinical investigation.
[97] S. Epstein,et al. Gene therapy for vascular disease , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[98] T. Ogihara,et al. A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[99] G. Condorelli,et al. Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo , 1995, Nature Medicine.
[100] N. Yang,et al. Gene gun and other non-viral approaches for cancer gene therapy , 1995, Nature Medicine.
[101] Y. Kaneda,et al. Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[102] J. Seltzer,et al. Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product , 1995, Science.
[103] S. Russell. Replicating vectors for cancer therapy: a question of strategy. , 1994, Seminars in cancer biology.
[104] Moolten Fl. Drug sensitivity ("suicide") genes for selective cancer chemotherapy. , 1994 .
[105] J. Burns,et al. A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[106] E. Nabel,et al. Gene therapy for vascular smooth muscle cell proliferation after arterial injury. , 1994, Science.
[107] E. Jaffee,et al. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. , 1994, Science.
[108] S. Epstein,et al. Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. , 1994, Circulation.
[109] E. Brogi,et al. Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. , 1994, The Journal of clinical investigation.
[110] T. Ogihara,et al. Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[111] D Needham,et al. Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue. , 1993, Cancer research.
[112] H. T. Yang,et al. Angiotensin-converting enzyme inhibition increases collateral-dependent muscle blood flow. , 1993, Journal of applied physiology.
[113] G. Nabel,et al. Immunotherapy of malignancy by in vivo gene transfer into tumors. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[114] G. Nemerow,et al. Integrins α v β 3 and α v β 5 promote adenovirus internalization but not virus attachment , 1993, Cell.
[115] E. Jaffee,et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[116] M. Colombo,et al. Local cytokine availability elicits tumor rejection and systemic immunity through granulocyte-T-lymphocyte cross-talk. , 1992, Cancer research.
[117] Michael Simons,et al. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo , 1992, Nature.
[118] M. Gossen,et al. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[119] J. D. Watson. The human genome project: past, present, and future. , 1990, Science.
[120] R. Samulski,et al. AAV vectors: is clinical success on the horizon? , 2000, Gene Therapy.
[121] T. Clackson,et al. Regulated gene expression systems , 2000, Gene Therapy.
[122] Leaf Huang,et al. Nonviral gene therapy: promises and challenges , 2000, Gene Therapy.
[123] K. Yanagihara,et al. Effects of epidermal growth factor, transferrin, and insulin on lipofection efficiency in human lung carcinoma cells , 2000, Cancer Gene Therapy.
[124] T. Hollon. Researchers and regulators reflect on first gene therapy death , 2000, Nature Medicine.
[125] F. Szoka,et al. Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer–plasmid complexes , 1999, Gene Therapy.
[126] Y. Kaneda. Development of a novel fusogenic viral liposome system (HVJ-liposomes) and its applications to the treatment of acquired diseases. , 1999, Molecular membrane biology.
[127] R. Crystal,et al. Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart. , 1998, The Journal of thoracic and cardiovascular surgery.
[128] J. Isner. Angiogenesis and Collateral Formation , 1997 .
[129] Von der Leyen. Gene therapy inhibiting neointimal vascular lesion , 1995 .
[130] E. Nabel,et al. Complex models for the study of gene function in cardiovascular biology. , 1994, Annual review of physiology.