Median infective dose of Treponema pallidum determined in a highly susceptible guinea pig strain

The median infective dose of Treponema pallidum subsp. pallidum and the production of immunity to reinfection in C4D guinea pigs have been determined with 10(1) to 10(6) organisms per infective dose. The mean infective dose is 10(2) organisms, and immunity--in those animals that demonstrated lesions--developed after 4.5 months postinfection.

[1]  J. Ząbek,et al.  Experimental neonatal syphilis in a susceptible (C4D) and a resistant (Albany) strain of guinea pig. , 1990, Clinical immunology and immunopathology.

[2]  J. V. van Embden,et al.  Immunogenicity of three recombinant Treponema pallidum antigens examined in guinea pigs. , 1989, International archives of allergy and applied immunology.

[3]  R. Baughn.  Congenital syphilis: immunologic challenges. , 1989, Pathology and immunopathology research.

[4]  K. Wicher,et al.  Experimental syphilis in guinea pig. , 1989, Critical reviews in microbiology.

[5]  R. Gruhn,et al.  Factors affecting the clinical course of Treponema pallidum infection in guinea pigs. , 1988, International archives of allergy and applied immunology.

[6]  S. Nakeeb,et al.  Adoptive transfer of immunity to Treponema pallidum Nichols infection in inbred strain 2 and C4D guinea pigs , 1987, Infection and immunity.

[7]  K. Wicher,et al.  Humoral response in Treponema pallidum-infected guinea pigs: I. Antibody specificity. , 1987, Clinical and experimental immunology.

[8]  R. Baughn,et al.  Humoral response in Treponema pallidum-infected guinea pigs. II. Circulating immune complexes and autoimmune responses. , 1987, Journal of immunology.

[9]  D. Bitter‐Suermann,et al.  Guinea pigs deficient in C2, C4, C3 or the C3a receptor. , 1986, Progress in allergy.

[10]  C. Pavia,et al.  Experimental infection of inbred guinea pigs with Treponema pallidum: development of lesions and formation of antibodies. , 1985, Genitourinary medicine.

[11]  R. Gruhn,et al.  Differences in susceptibility to infection with Treponema pallidum (Nichols) between five strains of guinea pig. , 1985, Genitourinary medicine.

[12]  S. Nakeeb,et al.  Experimental syphilis: guinea pig model. , 1983, The British journal of venereal diseases.

[13]  E. Shevach,et al.  Evaluation of the role of C4 in the cellular immune response in vitro. , 1979, Journal of immunology.

[14]  R. Webster,et al.  C4 synthesis in C4-deficient guinea pig radiation chimeras: restoration of the classic complement pathway. , 1976, Journal of immunology.

[15]  M. Frank,et al.  Bactericidal and opsonic properties of C4-deficient guinea pig serum. , 1972, Journal of immunology.

[16]  M. Frank,et al.  IN VIVO STUDIES IN C4-DEFICIENT GUINEA PIGS , 1971, The Journal of experimental medicine.

[17]  M. Frank,et al.  IN VITRO STUDIES OF COMPLEMENT FUNCTION IN SERA OF C4-DEFICIENT GUINEA PIGS , 1971, The Journal of experimental medicine.

[18]  I. Green,et al.  Genetically Controlled Total Deficiency of the Fourth Component of Complement in the Guinea Pig , 1970, Science.

[19]  P. Koller,et al.  Radiation chimeras. , 1961, Advances in cancer research.

[20]  H. J. Magnuson,et al.  INOCULATION SYPHILIS IN HUMAN VOLUNTEERS , 1956, Medicine.

[21]  H. Eagle,et al.  The minimal infectious inoculum of Spirochaeta pallida (Nichols strain) and a consideration of its rate of multiplication in vivo. , 1948, American journal of syphilis, gonorrhea, and venereal diseases.