Coenzyme A fuels T cell anti-tumor immunity.

[1]  B. Kishore,et al.  Conversion of extracellular ATP into adenosine: a master switch in renal health and disease , 2020, Nature Reviews Nephrology.

[2]  P. Ohashi,et al.  The Roles of CD8+ T Cell Subsets in Antitumor Immunity. , 2020, Trends in cell biology.

[3]  M. Lenardo,et al.  A guide to cancer immunotherapy: from T cell basic science to clinical practice , 2020, Nature Reviews Immunology.

[4]  Lindsay K. Pino,et al.  The Skyline ecosystem: Informatics for quantitative mass spectrometry proteomics. , 2020, Mass spectrometry reviews.

[5]  P. Naquet,et al.  Regulation of coenzyme A levels by degradation: the 'Ins and Outs'. , 2020, Progress in lipid research.

[6]  Trevor J Pugh,et al.  IL6 Induces an IL22+ CD8+ T-cell Subset with Potent Antitumor Function , 2020, Cancer Immunology Research.

[7]  J. Locasale,et al.  T cell stemness and dysfunction in tumors are triggered by a common mechanism , 2019, Science.

[8]  Jianguo Xia,et al.  MetaboAnalystR 2.0: From Raw Spectra to Biological Insights , 2019, Metabolites.

[9]  D. Cescon,et al.  AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer , 2019, Proceedings of the National Academy of Sciences.

[10]  Russell G. Jones,et al.  Activation of Peroxisome Proliferator-Activated Receptors α and δ Synergizes with Inflammatory Signals to Enhance Adoptive Cell Therapy. , 2019, Cancer research.

[11]  J. Locasale,et al.  Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism , 2018, Cell.

[12]  K. Pilipow,et al.  Antioxidant metabolism regulates CD8+ T memory stem cell formation and antitumor immunity. , 2018, JCI insight.

[13]  E. Hanse,et al.  The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells , 2018, Nature.

[14]  Simon C Watkins,et al.  4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses , 2018, The Journal of experimental medicine.

[15]  Laurence Zitvogel,et al.  Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors , 2018, Science.

[16]  E. Le Chatelier,et al.  Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients , 2018, Science.

[17]  G. Freeman,et al.  Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. , 2017, Cancer cell.

[18]  T. Honjo,et al.  Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity , 2017, Proceedings of the National Academy of Sciences.

[19]  L. Zenewicz,et al.  Transcription Factor HIF-1α Controls Expression of the Cytokine IL-22 in CD4 T Cells , 2016, The Journal of Immunology.

[20]  E. Wherry,et al.  Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion. , 2016, Immunity.

[21]  Simon C Watkins,et al.  The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. , 2016, Immunity.

[22]  L. Chin,et al.  Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade. , 2016, Cancer discovery.

[23]  J. Rathmell,et al.  A guide to immunometabolism for immunologists , 2016, Nature Reviews Immunology.

[24]  O. Kretz,et al.  Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming , 2016, Cell.

[25]  G. V. D. van der Windt,et al.  Measuring Bioenergetics in T Cells Using a Seahorse Extracellular Flux Analyzer , 2016, Current protocols in immunology.

[26]  Chih-Hao Chang,et al.  Emerging concepts of T cell metabolism as a target of immunotherapy , 2016, Nature Immunology.

[27]  Brian Keith,et al.  Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells. , 2016, Immunity.

[28]  Jason B. Williams,et al.  Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy , 2015, Science.

[29]  A. Regev,et al.  CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity , 2015, Cell.

[30]  H. Petković,et al.  Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis. , 2015, Nature chemical biology.

[31]  V. de Crécy-Lagard,et al.  Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes , 2015, Front. Genet..

[32]  Mark S. Sundrud,et al.  Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics. , 2015, Cancer research.

[33]  J. Locasale,et al.  Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. , 2015, The Journal of clinical investigation.

[34]  S. Filler,et al.  OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 111 ( 51 ) ISSN 0027-8424 , 2014 .

[35]  Y. Li,et al.  IL-22 Fate Reporter Reveals Origin and Control of IL-22 Production in Homeostasis and Infection , 2014, The Journal of Immunology.

[36]  Nataliya Gorinski,et al.  De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells , 2014, Nature Medicine.

[37]  M. Birnbaum,et al.  Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. , 2014, Immunity.

[38]  M. Huber,et al.  Heterogeneity in the Differentiation and Function of CD8+ T Cells , 2014, Archivum Immunologiae et Therapiae Experimentalis.

[39]  John P. Overington,et al.  An atlas of genetic influences on human blood metabolites , 2014, Nature Genetics.

[40]  Chih-Hao Chang,et al.  Fueling Immunity: Insights into Metabolism and Lymphocyte Function , 2013, Science.

[41]  B. Faubert,et al.  Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis , 2013, Cell.

[42]  Liang Zheng,et al.  Succinate is an inflammatory signal that induces IL-1β through HIF-1α , 2013, Nature.

[43]  C. Klebanoff,et al.  Paths to stemness: building the ultimate antitumour T cell , 2012, Nature Reviews Cancer.

[44]  G. V. D. van der Windt,et al.  Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. , 2012, Immunity.

[45]  J. Gommerman,et al.  Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells , 2011, Nature Medicine.

[46]  P. Ohashi,et al.  Immunological perspective of self versus tumor antigens: insights from the RIP‐gp model , 2011, Immunological reviews.

[47]  J. Rathmell,et al.  Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets , 2011, The Journal of Immunology.

[48]  M. Veldhoen,et al.  The aryl hydrocarbon receptor: fine-tuning the immune-response. , 2010, Current opinion in immunology.

[49]  Russell G. Jones,et al.  Enhancing CD8 T-cell memory by modulating fatty acid metabolism , 2009, Nature.

[50]  B. Ebert,et al.  Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo , 2006 .

[51]  D. Speiser,et al.  Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance , 2002, The Journal of experimental medicine.

[52]  R. Zinkernagel,et al.  Virus‐specific major MHC class II‐restricted TCR‐transgenic mice: effects on humoral and cellular immune responses after viral infection , 1998, European journal of immunology.

[53]  H. Pircher,et al.  Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen , 1989, Nature.

[54]  C. Rock,et al.  Regulation of pantothenate kinase by coenzyme A and its thioesters. , 1987, The Journal of biological chemistry.

[55]  David G. Watson,et al.  Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. , 2005, Cancer cell.