MR-guided laser interventions

Low-power interstitial thermal therapy using a 1064 nm Nd:YAG laser and a newly designed fiberoptic transmission system, the ITT laser fiber, is a promising therapeutic approach in the treatment of cerebral tumors. After CT-guided stereotactic implantation of an applicator probe, we performed laser-induced interstitial thermal therapy in a patient with an astrocytomas WHO grade II under simultaneous magnetic resonance imaging (MRI) control. In order to assess the effects of the treatment a 2D-Flash sequence with an acquisition time of 15 sec was used. It could be demonstrated that laser-tissue interactions progressed with duration of irradiation depending on laser powers applied. There was a well-defined area of tissue necrosis with a maximum size of 17 mm in diameter in the center of the tumor and a small zone of transient perifocal edema. With regard to experimental studies, it seems to be possible to define between reversible and irreversible laser-tissue effects.

[1]  F Frank,et al.  [Nd-Yag laser in neurosurgery]. , 1984, MMW, Munchener medizinische Wochenschrift.

[2]  M Kiessling,et al.  Time course and spatial distribution of neodymium: yttrium-aluminum-garnet (Nd:YAG) laser-induced lesions in the rat brain. , 1985, Neurosurgery.

[3]  M Kiessling,et al.  Cerebrovascular and metabolic effects on the rat brain of focal Nd:YAG laser irradiation. , 1990, Journal of neurosurgery.

[4]  J Hahl,et al.  Laser‐Induced hyperthermia in the treatment of liver tumors , 1990, Lasers in surgery and medicine.

[5]  A. Welch,et al.  The thermal response of laser irradiated tissue , 1984, IEEE Journal of Quantum Electronics.

[6]  M Ohyama,et al.  Laserthermia: A new computer‐controlled contact Nd:YAG system for interstitial local hyperthermia , 1988, Lasers in surgery and medicine.

[7]  T. Foster,et al.  A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1-100 MHz: dependence on tissue type, NMR frequency, temperature, species, excision, and age. , 1984, Medical physics.

[8]  J. Hand,et al.  Heating techniques in hyperthermia , 1981 .

[9]  S. Hessel,et al.  Technical prerequisites for the interstitial thermotherapy using the Nd:YAG laser , 1990, Photonics West - Lasers and Applications in Science and Engineering.

[10]  M Salcman,et al.  Feasibility of microwave hyperthermia for brain tumor therapy. , 1984, Progress in experimental tumor research.

[11]  K. Uemura,et al.  Stereotactic interstitial laser-hyperthermia using Nd-YAG laser. , 1990, Stereotactic and functional neurosurgery.

[12]  A. Cheung,et al.  Deep local hyperthermia for cancer therapy: external electromagnetic and ultrasound techniques. , 1984, Cancer research.

[13]  W. Coley,et al.  THE TREATMENT OF MALIGNAT TUMORS BY REPEATED INOCULATIONS OF ERYSIPELAS: WITH A REPORT OF TEN ORIGINAL CASES , 1893 .

[14]  D L Parker,et al.  Temperature distribution measurements in two-dimensional NMR imaging. , 1983, Medical physics.

[15]  M. Nauenberg,et al.  Thermal effects of laser radiation in biological tissue. , 1983, Biophysical journal.

[16]  Martin Bettag,et al.  Gadolinium-DTPA-enhanced MRI and positron emission tomography of stereotactic laser-induced interstitial thermal therapy in cerebral gliomas , 1991 .

[17]  Ryuichi Tanaka,et al.  Radiofrequency hyperthermia for malignant brain tumors: preliminary results of clinical trials. , 1987, Neurosurgery.