DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathway.
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Linting Wei | Zhao Chen | Li Wang | Xianghui Chen | Weihao Zhao | Yuzhan Zhang | Ke Li | Yan Li | Pengfei Liu | Rongguo Fu | Xuefei Tian | Rongrong Wang | Na Nie
[1] Xuefei Tian,et al. New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors , 2022, Frontiers in Pharmacology.
[2] Xiancheng Li,et al. Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells. , 2021, Pharmacological research.
[3] S. Gygi,et al. DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation , 2021, Nature.
[4] N. Frangogiannis,et al. The role of Smad signaling cascades in cardiac fibrosis. , 2020, Cellular signalling.
[5] De-juan Sun,et al. Si-Miao-Yong-An Decoction attenuates isoprenaline-induced myocardial fibrosis in AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[6] B. Zhang,et al. PTEN improve renal fibrosis in vitro and in vivo through inhibiting FAK/AKT signaling pathway , 2019, Journal of cellular biochemistry.
[7] I. Plastira,et al. Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes , 2018, Front. Physiol..
[8] Wanrong Wu,et al. Targeting dipeptidyl peptidase 8 genes inhibits proliferation, migration and invasion by inhibition of cyclin D1 and MMP2MMP9 signal pathway in cervical cancer , 2018, The journal of gene medicine.
[9] A. Kentsis,et al. DPP8/9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia , 2018, Nature Medicine.
[10] S. Sánchez,et al. Extracellular matrix remodeling and TGF‐β1/Smad signaling in diabetic colon mucosa , 2018, Cell biology international.
[11] C. Henke,et al. Extracellular matrix as a driver of progressive fibrosis. , 2018, The Journal of clinical investigation.
[12] W. Wang,et al. Contribution of upregulated dipeptidyl peptidase 9 (DPP9) in promoting tumoregenicity, metastasis and the prediction of poor prognosis in non‐small cell lung cancer (NSCLC) , 2017, International journal of cancer.
[13] J. Jakić-Razumović,et al. Dipeptidyl peptidase 9 (DPP9) in human skin cells. , 2017, Immunobiology.
[14] S. Hörsten,et al. Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and/or structure homologue (DASH) proteins , 2016, Clinical and experimental immunology.
[15] A. Lambeir,et al. The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis , 2015, Front. Immunol..
[16] Lin Sun,et al. Insights into the Mechanisms Involved in the Expression and Regulation of Extracellular Matrix Proteins in Diabetic Nephropathy. , 2015, Current medicinal chemistry.
[17] Zhangsuo Liu,et al. Proliferation and Cytokine Production of Human Mesangial Cells Stimulated by Secretory IgA Isolated from Patients with IgA Nephropathy , 2015, Cellular Physiology and Biochemistry.
[18] Z. Werb,et al. Remodelling the extracellular matrix in development and disease , 2014, Nature Reviews Molecular Cell Biology.
[19] S. Hubchak,et al. Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis. , 2013, American journal of physiology. Renal physiology.
[20] Yiqian Chen,et al. Advances in Understanding the Expression and Function of Dipeptidyl Peptidase 8 and 9 , 2013, Molecular Cancer Research.
[21] K. Block,et al. Nox4 and diabetic nephropathy: with a friend like this, who needs enemies? , 2013, Free radical biology & medicine.
[22] F. Reinholt,et al. Diabetic Nephropathy and Extracellular Matrix , 2012, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[23] S. Kaneko,et al. Matrix metalloproteinase-2 (MMP-2) and membrane-type 1 MMP (MT1-MMP) affect the remodeling of glomerulosclerosis in diabetic OLETF rats. , 2011, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
[24] Rong Wang,et al. The Role of the p38 MAPK Signaling Pathway in High Glucose-Induced Epithelial-Mesenchymal Transition of Cultured Human Renal Tubular Epithelial Cells , 2011, PloS one.
[25] Kang-Yell Choi,et al. A Novel Role of Dipeptidyl Peptidase 9 in Epidermal Growth Factor Signaling , 2011, Molecular Cancer Research.
[26] Xin Chen,et al. Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. , 2009, Biochemical pharmacology.
[27] Hyun Soon Lee,et al. Differential role of mesangial cells and podocytes in TGF-beta-induced mesangial matrix synthesis in chronic glomerular disease. , 2009, Histology and histopathology.
[28] Xin Chen,et al. Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8. , 2005, Bioorganic & medicinal chemistry letters.
[29] Y. Kurogi. Mesangial cell proliferation inhibitors for the treatment of proliferative glomerular disease , 2003, Medicinal research reviews.
[30] D. Yue,et al. The role of the mesangial cell and its matrix in the pathogenesis of diabetic nephropathy. , 1999, Cellular and molecular biology.
[31] J. Egido,et al. Receptors for immune complexes activate gene expression and synthesis of matrix proteins in cultured rat and human mesangial cells: role of TGF-beta. , 1996, Journal of immunology.
[32] Jing-hong Zhao. Mesangial Cells and Renal Fibrosis. , 2019, Advances in experimental medicine and biology.
[33] Taotao Ma,et al. TGF-β/Smad and Renal Fibrosis. , 2019, Advances in experimental medicine and biology.
[34] H. Wilson,et al. Glomerular epithelial and mesangial cell culture and characterization. , 2012, Methods in molecular biology.