Complexity and healthcare organization: a view from the street

Aims:  Atypical immature metaplasia (AIM) refers to a full‐thickness intraepithelial basaloid lesion in the uterine cervix that features both metaplasia and atypia and is therefore difficult to distinguish from high‐grade cervical intraepithelial neoplasia (CIN III). p16 is a marker for human papillomavirus (HPV)‐induced dysplasia. Cytokeratin (CK) 17 is a marker for cervical reserve (stem) cells, which give rise to metaplasia. The aim was to determine whether AIM can be reclassified into metaplasia and CIN III based on p16 and CK17 immunohistochemistry.

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