An interactive tool for rapid biventricular analysis of congenital heart disease

Cardiac malformations are the most common birth defect. Better interventions in early life have improved mortality for children with congenital heart disease, but heart failure is a significant problem in adulthood. These patients require regular imaging and analysis of biventricular (left and right ventricular) function. In this study, we describe a rapid method to analyse left and right ventricular shape and function from cardiac MRI examinations. A 4D (3D+time) finite element model template is interactively customized to the anatomy and motion of the biventricular unit. The method was validated in 17 patients and 10 ex‐vivo hearts. Interactive model updates were achieved through preconditioned conjugate gradient optimization on a multithread system, and by precomputing points predicted from a coarse mesh optimization.

[1]  Poul Michael Fonss Nielsen.  The anatomy of the heart : a finite element model , 1987 .

[2]  B. Cowan,et al.  In-line automated tracking for ventricular function with magnetic resonance imaging. , 2010, JACC. Cardiovascular imaging.

[3]  Alistair A. Young,et al.  Left Ventricular Mass and Volume: Fast Calculation with Guide-Point Modeling , 2000 .

[4]  Endong Wang,et al.  Intel Math Kernel Library , 2014 .

[5]  Daniel Rueckert,et al.  Spatio-Temporal Free-Form Registration of Cardiac MR Image Sequences , 2004, MICCAI.

[6]  Stefan Neubauer,et al.  Normal human left and right ventricular and left atrial dimensions using steady state free precession magnetic resonance imaging. , 2005, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[7]  Michael Jerosch-Herold,et al.  Three-dimensional shape analysis of right ventricular remodeling in repaired tetralogy of Fallot. , 2008, The American journal of cardiology.

[8]  S. Hunt,et al.  Right Ventricular Function in Cardiovascular Disease, Part II: Pathophysiology, Clinical Importance, and Management of Right Ventricular Failure , 2008, Circulation.

[9]  James C Moon,et al.  Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic resonance. , 2004, American heart journal.

[10]  A. Roos,et al.  Imaging of patients with congenital heart disease , 2012, Nature Reviews Cardiology.

[11]  Peter J Hunter,et al.  Sarcomere length changes in a 3D mathematical model of the pig ventricles. , 2003, Progress in biophysics and molecular biology.

[12]  W SederbergThomas,et al.  Free-form deformation of solid geometric models , 1986 .

[13]  Christopher M Haggerty,et al.  Patients with repaired tetralogy of Fallot suffer from intra- and inter-ventricular cardiac dyssynchrony: a cardiac magnetic resonance study. , 2014, European heart journal cardiovascular Imaging.

[14]  Roy W. Martin,et al.  Three-dimensional echocardiographic measurement of left and right ventricular mass and volume: in vitro validation , 2002, The International Journal of Cardiovascular Imaging.

[15]  S. Solomon,et al.  Usefulness of right ventricular fractional area change to predict death, heart failure, and stroke following myocardial infarction (from the VALIANT ECHO Study). , 2008, The American journal of cardiology.

[16]  Justin W. Fernandez,et al.  Anatomically based geometric modelling of the musculo-skeletal system and other organs , 2004, Biomechanics and modeling in mechanobiology.

[17]  W. J. Hedley,et al.  Left ventricular mass and volume: fast calculation with guide-point modeling on MR images. , 2000, Radiology.

[18]  Mark A. Fogel,et al.  Ventricular function and blood flow in congenital heart disease , 2007 .

[19]  S. Colan,et al.  Midwall shortening after coarctation repair: the effect of through-plane motion on single-plane indices of left ventricular function. , 2005, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[20]  Bin Gu,et al.  Direct Estimation of Cardiac Biventricular Volumes With an Adapted Bayesian Formulation , 2014, IEEE Transactions on Biomedical Engineering.

[21]  Philipp Birken,et al.  Numerical Linear Algebra , 2011, Encyclopedia of Parallel Computing.

[22]  Alistair A. Young,et al.  The Cardiac Atlas Project—an imaging database for computational modeling and statistical atlases of the heart , 2011, Bioinform..

[23]  Thomas W. Sederberg,et al.  Free-form deformation of solid geometric models , 1986, SIGGRAPH.

[24]  Hopewell N. Ntsinjana,et al.  The Role of Cardiovascular Magnetic Resonance in Pediatric Congenital Heart Disease , 2011, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[25]  Daniel Rueckert,et al.  Fast Spatio-temporal Free-Form Registration of Cardiac MR Image Sequences , 2004, FIMH.