Recently, the author successfully applied the classic Wilhelmy balance method and the dynamic contact angle analysis (DCA) on initial interfacial reactions of surface-modified biomaterials. In this study, the authors present further results which underline the potential of these methods to yield time-resolved data of ionic and protein interfacial reactions. In contrast to many spectroscopic methods, an on-line method, which works time-resolved and without disturbing the interface, would be important in the process-engineered quality control. This is underlined by the fact, that many biomedical material surfaces currently are pre-biofunctionalized before their application in order to increase their biocompatibility and bifunctionality. The above-outlined statement of the problems involves many disciplines. In this approach, it is highlighted and discussed on the background of current research on biomaterials.