Using random networks to study the dynamics of respiratory syncytial virus (RSV) in the Spanish region of Valencia

Seasonal fluctuations in the incidence of several respiratory infections are a feature of epidemiological surveys all around the world. This phenomenon is characteristic of influenza and respiratory syncytial virus pandemics. However, the explanation of the seasonal outbreaks of these diseases remains poorly understood. Many statistical studies have been carried out in order to provide a correlation of the outbreaks with climatic or social factors without achieving a definitive conclusion. Here we show that, in a random social network, self-sustained seasonal epidemics emerge as a process modulated by the infection probability and the immunity period after recovering from the infection. This is a purely endogenous phenomenon that does not require any exogenous forcing. Assuming that this is the dominant mechanism for seasonal epidemics, many implications for public health policies for infectious respiratory diseases could be drawn.

[1]  Herbert W. Hethcote,et al.  The Mathematics of Infectious Diseases , 2000, SIAM Rev..

[2]  A. Weber,et al.  Modeling epidemics caused by respiratory syncytial virus (RSV). , 2001, Mathematical biosciences.

[3]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[4]  R. Welliver,et al.  Temperature, Humidity, and Ultraviolet B Radiation Predict Community Respiratory Syncytial Virus Activity , 2007, The Pediatric infectious disease journal.

[5]  F. W. Denny,et al.  Epidemiology of acute lower respiratory disease in children. , 1973, The New England journal of medicine.

[6]  Alessandro Vespignani,et al.  Epidemic spreading in scale-free networks. , 2000, Physical review letters.

[7]  C B Hall,et al.  Modes of transmission of respiratory syncytial virus. , 1981, The Journal of pediatrics.

[8]  Alessandro Vespignani,et al.  Epidemic dynamics in finite size scale-free networks. , 2002, Physical review. E, Statistical, nonlinear, and soft matter physics.

[9]  Elena N Naumova,et al.  Mystery of Seasonality: Getting the Rhythm of Nature , 2006, Journal of public health policy.

[10]  N. Christakis,et al.  The Spread of Obesity in a Large Social Network Over 32 Years , 2007, The New England journal of medicine.

[11]  R. Villanueva,et al.  Mathematical modelling of respiratory syncytial virus (RSV): vaccination strategies and budget applications , 2009, Epidemiology and Infection.

[12]  R. Feigin,et al.  Textbook of Pediatric Infectious Diseases , 1986 .

[13]  N. Christakis,et al.  SUPPLEMENTARY ONLINE MATERIAL FOR: The Collective Dynamics of Smoking in a Large Social Network , 2022 .

[14]  R. Prozorov Temperature , 1890, The Hospital.

[15]  R. Walker,et al.  Development of a PIV-vectored RSV vaccine: preclinical evaluation of safety, toxicity, and enhanced disease and initial clinical testing in healthy adults. , 2008, Vaccine.

[16]  N. E. Babady,et al.  Respiratory Syncytial Virus and Human Metapneumovirus , 2011 .

[17]  J. Díez Domingo,et al.  Incidencia y costes de la hospitalización por bronquiolitis y de las infecciones , 2006 .

[18]  Catherine H Mercer,et al.  Scale-Free Networks and Sexually Transmitted Diseases: A Description of Observed Patterns of Sexual Contacts in Britain and Zimbabwe , 2004, Sexually transmitted diseases.

[19]  Tamara J Meerhoff,et al.  Variation of Respiratory Syncytial Virus and the Relation With Meteorological Factors in Different Winter Seasons , 2009, The Pediatric infectious disease journal.

[20]  Jie Lou,et al.  The dynamics of spreading and immune strategies of sexually transmitted diseases on scale-free network , 2010 .

[21]  P. Cochat,et al.  Et al , 2008, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[22]  C B Hall,et al.  Respiratory syncytial viral infection in children with compromised immune function. , 1986, The New England journal of medicine.

[23]  J. Dushoff,et al.  Dynamical resonance can account for seasonality of influenza epidemics. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[24]  Aravind Srinivasan,et al.  Structure of Social Contact Networks and Their Impact on Epidemics , 2004, Discrete Methods in Epidemiology.