Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study).

[1]  J. Kohoutek,et al.  The exposure of Czech firefighters to perfluoroalkyl substances and polycyclic aromatic hydrocarbons: CELSPAC – FIREexpo case-control human biomonitoring study , 2023, The Science of the total environment.

[2]  Janet Ong,et al.  Perfluoroalkyl substances and lipid concentrations in the blood: A systematic review of epidemiological studies. , 2022, The Science of the total environment.

[3]  L. Chatzi,et al.  Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis , 2022, Environmental health perspectives.

[4]  Tyler D. Johnson,et al.  Perfluoroalkyl and Polyfluoroalkyl Substances in Groundwater Used as a Source of Drinking Water in the Eastern United States , 2022, Environmental science & technology.

[5]  J. González,et al.  State-of-the-art methods for exposure-health studies: Results from the exposome data challenge event. , 2022, Environment international.

[6]  M. Orešič,et al.  Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease. , 2021, Journal of hepatology.

[7]  R. Morello-Frosch,et al.  Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco , 2021, Environmental Health.

[8]  Jeong-eun Oh,et al.  Assessment of Exposure of Korean Firefighters to Polybrominated Diphenyl Ethers and Polycyclic Aromatic Hydrocarbons via Their Measurement in Serum and Polycyclic Aromatic Hydrocarbon Metabolites in Urine. , 2021, Environmental science & technology.

[9]  M. Longnecker,et al.  Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms , 2021, Toxicology.

[10]  S. Morais,et al.  Firefighters' occupational exposure: Contribution from biomarkers of effect to assess health risks. , 2021, Environment international.

[11]  A. Gu,et al.  Urinary biomarkers of polycyclic aromatic hydrocarbons and their associations with liver function in adolescents. , 2021, Environmental pollution.

[12]  B. Lindeman,et al.  Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not? , 2021, Critical reviews in toxicology.

[13]  Shimin Zheng,et al.  Association between per and polyfluoroalkyl substances and markers of inflammation and oxidative stress. , 2020, Environmental research.

[14]  P. Thai,et al.  Characterising the exposure of Australian firefighters to polycyclic aromatic hydrocarbons generated in simulated compartment fires. , 2020, International journal of hygiene and environmental health.

[15]  Carla A. Ng,et al.  Per‐ and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research , 2020, Environmental toxicology and chemistry.

[16]  T. Fletcher,et al.  Associations between perfluoroalkyl substances and lipid profile in a highly exposed young adult population in the Veneto Region. , 2020, Environment international.

[17]  R. Grashow,et al.  Gaussian graphical modeling of the serum exposome and metabolome reveals interactions between environmental chemicals and endogenous metabolites , 2020, Scientific Reports.

[18]  T. Fletcher,et al.  Perfluoroalkyl substances are associated with elevated blood pressure and hypertension in highly exposed young adults , 2020, Environmental Health.

[19]  E. Papadopoulou,et al.  Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children , 2020, Hepatology.

[20]  B. Rossbach,et al.  Internal Exposure of Firefighting Instructors to Polycyclic Aromatic Hydrocarbons (PAH) during live Fire Training. , 2020, Toxicology letters.

[21]  T. Fletcher,et al.  Associations between perfluoroalkyl substances and serum lipids in a Swedish adult population with contaminated drinking water , 2020, Environmental Health.

[22]  A. Fernandes,et al.  Firefighters exposure to fire emissions: Impact on levels of biomarkers of exposure to polycyclic aromatic hydrocarbons and genotoxic/oxidative-effects. , 2020, Journal of hazardous materials.

[23]  A. Braeuning,et al.  Activation of human nuclear receptors by perfluoroalkylated substances (PFAS). , 2020, Toxicology in vitro : an international journal published in association with BIBRA.

[24]  Y. Hwang,et al.  The association between total serum isomers of per- and polyfluoroalkyl substances, lipid profiles, and the DNA oxidative/nitrative stress biomarkers in middle-aged Taiwanese adults. , 2019, Environmental research.

[25]  Fang Li,et al.  Hepatotoxic effects of inhalation exposure to polycyclic aromatic hydrocarbons on lipid metabolism of C57BL/6 mice. , 2019, Environment international.

[26]  E. Colicino,et al.  Per- and poly-fluoroalkyl substances and bone mineral density , 2019, Environmental epidemiology.

[27]  C. Christophi,et al.  Cancer Incidence and Mortality in Firefighters: A State-of-the-Art Review and Meta-Analysis , 2019, Asian Pacific journal of cancer prevention : APJCP.

[28]  D. Dumitrascu,et al.  Cardiovascular Risk in Fatty Liver Disease: The Liver-Heart Axis—Literature Review , 2019, Front. Med..

[29]  R. Morello-Frosch,et al.  Exposure to Perfluoroalkyl Substances in a Cohort of Women Firefighters and Office Workers in San Francisco. , 2019, Environmental science & technology.

[30]  M. Lag,et al.  Potential role of polycyclic aromatic hydrocarbons as mediators of cardiovascular effects from combustion particles , 2019, Environmental Health.

[31]  R. Attanasio Sex differences in the association between perfluoroalkyl acids and liver function in US adolescents: Analyses of NHANES 2013-2016. , 2019, Environmental pollution.

[32]  Denise L. Smith,et al.  Firefighters' and instructors’ absorption of PAHs and benzene during training exercises , 2019, International journal of hygiene and environmental health.

[33]  H. Yao,et al.  Polycyclic aromatic hydrocarbons exposure and hematotoxicity in occupational population: A two-year follow-up study. , 2019, Toxicology and applied pharmacology.

[34]  Denise L. Smith,et al.  Firefighters’ absorption of PAHs and VOCs during controlled residential fires by job assignment and fire attack tactic , 2019, Journal of Exposure Science & Environmental Epidemiology.

[35]  R. Naidu,et al.  Using 2003-2014 U.S. NHANES data to determine the associations between per- and polyfluoroalkyl substances and cholesterol: Trend and implications. , 2019, Ecotoxicology and environmental safety.

[36]  Fang Li,et al.  Dysregulation of lipid metabolism induced by airway exposure to polycyclic aromatic hydrocarbons in C57BL/6 mice. , 2019, Environmental pollution.

[37]  J. Sommar,et al.  Associations between repeated measure of plasma perfluoroalkyl substances and cardiometabolic risk factors. , 2019, Environment international.

[38]  Heather M. Wallace,et al.  Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food , 2018, EFSA journal. European Food Safety Authority.

[39]  Balaji Meriga,et al.  Role of glutathione S-transferases in detoxification of a polycyclic aromatic hydrocarbon, methylcholanthrene. , 2018, Chemico-biological interactions.

[40]  Gang Wu,et al.  Identification of hepatotoxicity and renal dysfunction of pyrene in adult male rats , 2018, Environmental toxicology.

[41]  H. Stapleton,et al.  Perfluorinated Chemicals as Emerging Environmental Threats to Kidney Health: A Scoping Review. , 2018, Clinical journal of the American Society of Nephrology : CJASN.

[42]  L. Lind,et al.  Changes in markers of liver function in relation to changes in perfluoroalkyl substances - A longitudinal study. , 2018, Environment international.

[43]  Nam Hoon Kim,et al.  Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study , 2018, Scientific Reports.

[44]  U. Vogel,et al.  Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises , 2018, Mutagenesis.

[45]  Cecilia Hammar Wijkmark,et al.  Impact of Fire Suit Ensembles on Firefighter PAH Exposures as Assessed by Skin Deposition and Urinary Biomarkers , 2017, Annals of work exposures and health.

[46]  K. Broberg,et al.  Early markers of cardiovascular disease are associated with occupational exposure to polycyclic aromatic hydrocarbons , 2017, Scientific Reports.

[47]  U. Apte,et al.  The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction. , 2016, Toxicology and applied pharmacology.

[48]  Kathrene R. Conway,et al.  A cross-sectional survey of occupational history as a wildland firefighter and health. , 2016, American journal of industrial medicine.

[49]  M. Andrew,et al.  The association of urinary polycyclic aromatic hydrocarbon biomarkers and cardiovascular disease in the US population. , 2016, Environment international.

[50]  K. Steenland,et al.  Modeled Perfluorooctanoic Acid (PFOA) Exposure and Liver Function in a Mid-Ohio Valley Community , 2016, Environmental health perspectives.

[51]  L. Toms,et al.  Elevated levels of PFOS and PFHxS in firefighters exposed to aqueous film forming foam (AFFF). , 2015, Environment international.

[52]  Hyun-Sul Lim,et al.  Biomarkers for polycyclic aromatic hydrocarbons and serum liver enzymes. , 2015, American journal of industrial medicine.

[53]  M. Long,et al.  Perfluoroalkylated substances (PFAS) affect oxidative stress biomarkers in vitro. , 2015, Chemosphere.

[54]  D. J. Carlin,et al.  Polycyclic aromatic hydrocarbons: from metabolism to lung cancer. , 2015, Toxicological sciences : an official journal of the Society of Toxicology.

[55]  Mats Fredrikson,et al.  Fibrosis stage is the strongest predictor for disease‐specific mortality in NAFLD after up to 33 years of follow‐up , 2015, Hepatology.

[56]  June-Soo Park,et al.  High exposure of California firefighters to polybrominated diphenyl ethers. , 2015, Environmental science & technology.

[57]  Anna Kärrman,et al.  Novel fluorinated surfactants tentatively identified in firefighters using liquid chromatography quadrupole time-of-flight tandem mass spectrometry and a case-control approach. , 2015, Environmental science & technology.

[58]  Keqiu Li,et al.  Polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress for a rural population from the North China Plain , 2015, Environmental Science and Pollution Research.

[59]  June-Soo Park,et al.  Biomonitoring in California Firefighters , 2015, Journal of occupational and environmental medicine.

[60]  J. Koponen,et al.  Firefighters' exposure to perfluoroalkyl acids and 2-butoxyethanol present in firefighting foams. , 2014, Toxicology letters.

[61]  P. Schlattmann,et al.  Occupational polycyclic aromatic hydrocarbon exposure and risk of larynx cancer: a systematic review and meta-analysis , 2014, Occupational and Environmental Medicine.

[62]  Yuanxiang Jin,et al.  Sub-chronically exposing mice to a polycyclic aromatic hydrocarbon increases lipid accumulation in their livers. , 2014, Environmental toxicology and pharmacology.

[63]  F. Thiesen,et al.  Atherosclerotic process in taxi drivers occupationally exposed to air pollution and co-morbidities. , 2014, Environmental research.

[64]  T. Reponen,et al.  Exposure of Firefighters to Particulates and Polycyclic Aromatic Hydrocarbons , 2014, Journal of occupational and environmental hygiene.

[65]  Ki-Hyun Kim,et al.  A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects. , 2013, Environment international.

[66]  M. Shima,et al.  Consumption of Seafood, Serum Liver Enzymes, and Blood Levels of PFOS and PFOA in the Japanese Population , 2013, Journal of occupational health.

[67]  J. Laitinen,et al.  Firefighters' multiple exposure assessments in practice. , 2012, Toxicology letters.

[68]  G. Leonardi,et al.  Serum Perfluorooctanoate (PFOA) and Perfluorooctane Sulfonate (PFOS) Concentrations and Liver Function Biomarkers in a Population with Elevated PFOA Exposure , 2012, Environmental health perspectives.

[69]  C. Christophi,et al.  Firefighters' physical activity: relation to fitness and cardiovascular disease risk. , 2011, Medicine and science in sports and exercise.

[70]  Stefanos N. Kales,et al.  Cardiovascular Disease in US Firefighters: A Systematic Review , 2011, Cardiology in review.

[71]  E. Niki Assessment of antioxidant capacity in vitro and in vivo. , 2010, Free radical biology & medicine.

[72]  Pau-Chung Chen,et al.  Investigation of the Associations Between Low-Dose Serum Perfluorinated Chemicals and Liver Enzymes in US Adults , 2010, The American Journal of Gastroenterology.

[73]  Greger Lindberg,et al.  Decreased survival of subjects with elevated liver function tests during a 28‐year follow‐up , 2010, Hepatology.

[74]  V. Vaccarino,et al.  Association of perfluorooctanoic acid and perfluorooctane sulfonate with serum lipids among adults living near a chemical plant. , 2009, American journal of epidemiology.

[75]  S. Snyder,et al.  Bilirubin and glutathione have complementary antioxidant and cytoprotective roles , 2009, Proceedings of the National Academy of Sciences.

[76]  D. Consonni,et al.  Thirty Years of Medical Surveillance in Perfluooctanoic Acid Production Workers , 2009, Journal of occupational and environmental medicine.

[77]  John W Green,et al.  Cross-Sectional Study of Lipids and Liver Enzymes Related to a Serum Biomarker of Exposure (ammonium perfluorooctanoate or APFO) as Part of a General Health Survey in a Cohort of Occupationally Exposed Workers , 2007, Journal of occupational and environmental medicine.

[78]  Mark R Cullen,et al.  Longitudinal Study of Serum Lipids and Liver Enzymes in Workers With Occupational Exposure to Ammonium Perfluorooctanoate , 2007, Journal of occupational and environmental medicine.

[79]  Geary W Olsen,et al.  Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers , 2007, International archives of occupational and environmental health.

[80]  D. Dix,et al.  Toxicogenomic study of triazole fungicides and perfluoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity. , 2007, Toxicological sciences : an official journal of the Society of Toxicology.

[81]  L. Shaw,et al.  Community Exposure to Perfluorooctanoate: Relationships Between Serum Levels and Certain Health Parameters , 2006, Journal of occupational and environmental medicine.

[82]  Y. Benjamini,et al.  False Discovery Rate–Adjusted Multiple Confidence Intervals for Selected Parameters , 2005 .

[83]  J. Kapitulnik Bilirubin: An Endogenous Product of Heme Degradation with Both Cytotoxic and Cytoprotective Properties , 2004, Molecular Pharmacology.

[84]  J. Cerhan,et al.  Epidemiologic Evaluation of Measurement Data in the Presence of Detection Limits , 2004, Environmental Health Perspectives.

[85]  S. Snyder,et al.  Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. , 2004, Pediatrics.

[86]  J. Speakman,et al.  Physical activity and resting metabolic rate , 2003, Proceedings of the Nutrition Society.

[87]  A. Batlle,et al.  Bilirubin: its role in cytoprotection against oxidative stress. , 2002, The international journal of biochemistry & cell biology.

[88]  S. Ryter,et al.  The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. , 2000, Free radical biology & medicine.

[89]  S. Snyder,et al.  Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[90]  M L Tomaro,et al.  Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage. , 1994, Biochimica et biophysica acta.

[91]  O. Spydevold,et al.  The mechanism underlying the hypolipemic effect of perfluorooctanoic acid (PFOA), perfluorooctane sulphonic acid (PFOSA) and clofibric acid. , 1992, Biochimica et biophysica acta.

[92]  F. Fukai,et al.  Protection of glutathione S-transferase from bilirubin inhibition. , 1989, Journal of biochemistry.

[93]  D. Bevan,et al.  Benzo(a)pyrene disposition and metabolism in rats following intratracheal instillation. , 1986, Cancer research.

[94]  M. Uribe,et al.  Bilirubin as a Biomarker in Liver Disease , 2016 .

[95]  J. Gleason,et al.  Associations of perfluorinated chemical serum concentrations and biomarkers of liver function and uric acid in the US population (NHANES), 2007-2010. , 2015, Environmental research.

[96]  Ian Shrier,et al.  Reducing bias through directed acyclic graphs , 2008 .

[97]  Paul D Jones,et al.  Gene expression profiles in rat liver treated with perfluorooctanoic acid (PFOA). , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[98]  C. Guillemette Pharmacogenomics of human UDP-glucuronosyltransferase enzymes , 2003, The Pharmacogenomics Journal.

[99]  P. Chessex,et al.  Influence of bilirubin on the antioxidant capacity of plasma in newborn infants. , 1997, Biology of the neonate.