Incidence, serum IgE and TARC/CCL17 levels in atopic dermatitis associated with other allergic diseases: an update from the Ishigaki cohort.

Population cohort studies are important for understanding the current status of the target disease and its relation to comorbidity, gender, age, or environmental factors. To better understand atopic dermatitis (AD) and its related diseases, we initiated in 2001 a population cohort study of nursery school children from Ishigaki Island, Okinawa, Japan. The cohort study comprised a dermatologist-based physical examination, questionnaire administration, and blood sample analysis. The mean prevalence of AD was 6.3%. Questionnaire-based bronchial asthma and egg allergy in the children and paternal and sibling AD were statistically significant risk factors for AD. Boys with AD had a high incidence of asthma that was coexistent with a high serum total immunoglobulin E level. Also a high incidence of egg allergy was associated with greater AD severity as assessed by TARC/CCL17.

[1]  J. Hayashi,et al.  Filaggrin loss-of-function mutations are not a predisposing factor for atopic dermatitis in an Ishigaki Island under subtropical climate. , 2014, Journal of dermatological science.

[2]  M. Wickman,et al.  Eczema severity in preadolescent children and its relation to sex, filaggrin mutations, asthma, rhinitis, aggravating factors and topical treatment: a report from the BAMSE birth cohort , 2013, The British journal of dermatology.

[3]  R. Weller,et al.  Protease–antiprotease imbalance may be linked to potential defects in profilaggrin proteolysis in atopic dermatitis , 2012, The British journal of dermatology.

[4]  J. Marinković,et al.  Health‐related quality of life in patients with atopic dermatitis , 2012, The Journal of dermatology.

[5]  T. Bandurski,et al.  Relationship between serum levels of interleukin‐18, IgE and disease severity in patients with atopic dermatitis , 2011, Clinical and experimental dermatology.

[6]  M. Ohtsuki,et al.  Guidelines for management of atopic dermatitis , 2009, The Journal of dermatology.

[7]  J. Fujiwara,et al.  Serum levels of Th2 chemokines, CCL17, CCL22, and CCL27, were the important markers of severity in infantile atopic dermatitis , 2008, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[8]  J. Hayashi,et al.  Association factors for atopic dermatitis in nursery school children in Ishigaki islands - Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). , 2008, European journal of dermatology : EJD.

[9]  F. D. de Benedictis,et al.  Confirmation of the association between high levels of immunoglobulin E food sensitization and eczema in infancy: an international study , 2007, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[10]  J. Hayashi,et al.  Thymus and activation regulated chemokines in children with atopic dermatitis: Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). , 2007, European journal of dermatology : EJD.

[11]  J. Hayashi,et al.  Incidence of atopic dermatitis in nursery school children - a follow-up study from 2001 to 2004, Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). , 2006, European journal of dermatology : EJD.

[12]  Colin N A Palmer,et al.  Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis , 2006, Nature Genetics.

[13]  J. Hayashi,et al.  Prevalence of Atopic Dermatitis and Serum IgE Values in Nursery School Children in Ishigaki Island, Okinawa, Japan , 2005, The Journal of dermatology.

[14]  C. Lam,et al.  Serum concentration of macrophage‐derived chemokine may be a useful inflammatory marker for assessing severity of atopic dermatitis in infants and young children , 2003, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[15]  H. Ueda,et al.  Increase of adult atopic dermatitis (AD) in recent Japan , 2000 .

[16]  D. Strachan,et al.  Worldwide variations in the prevalence of symptoms of atopic eczema in the International Study of Asthma and Allergies in Childhood. , 1999, The Journal of allergy and clinical immunology.

[17]  K. Tanaka,et al.  Prevalence of childhood and adolescent atopic dermatitis in a Japanese population: comparison with the disease frequency examined 20 years ago. , 1998, Acta dermato-venereologica.

[18]  H. Williams,et al.  Is the prevalence of atopic dermatitis increasing? , 1992, Clinical and experimental dermatology.