Obacunone inhibits RANKL/M-CSF-mediated osteoclastogenesis by suppressing integrin- FAK-Src signaling.

[1]  Eun-Young Kim,et al.  Effects of Melandrium firmum Rohrbach on RANKL-induced osteoclast differentiation and OVX rats , 2021, Molecular Medicine Reports.

[2]  Hyung-Mun Yun,et al.  Limonoid Triterpene, Obacunone Increases Runt-Related Transcription Factor 2 to Promote Osteoblast Differentiation and Function , 2021, International journal of molecular sciences.

[3]  B. Alman,et al.  Monocyte/Macrophage Lineage Cells From Fetal Erythromyeloid Progenitors Orchestrate Bone Remodeling and Repair , 2021, Frontiers in Cell and Developmental Biology.

[4]  M. Shimaoka,et al.  Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin , 2020, Frontiers in Cell and Developmental Biology.

[5]  Jean X. Jiang,et al.  Osteocytes and Bone Metastasis , 2020, Frontiers in Endocrinology.

[6]  A. Shibli-Rahhal,et al.  Bone Health and Osteoporosis Prevention and Treatment , 2020, Clinical obstetrics and gynecology.

[7]  E. Della Bella,et al.  Bone's Response to Mechanical Loading in Aging and Osteoporosis: Molecular Mechanisms , 2020, Calcified Tissue International.

[8]  A. Mócsai,et al.  Osteoclast Signal Transduction During Bone Metastasis Formation , 2020, Frontiers in Cell and Developmental Biology.

[9]  Zhengtao Wang,et al.  Obacunone Protects Against Ulcerative Colitis in Mice by Modulating Gut Microbiota, Attenuating TLR4/NF-κB Signaling Cascades, and Improving Disrupted Epithelial Barriers , 2020, Frontiers in Microbiology.

[10]  B. He,et al.  Integrin‐associated molecules and signalling cross talking in osteoclast cytoskeleton regulation , 2020, Journal of cellular and molecular medicine.

[11]  S. Mani,et al.  Obacunone reduces inflammatory signalling and tumour occurrence in mice with chronic inflammation-induced colorectal cancer , 2020, Pharmaceutical biology.

[12]  S. Lim,et al.  FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation , 2019, Scientific Reports.

[13]  L. McNamara,et al.  Estrogen deficiency impairs integrin αvβ3-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling , 2019, Scientific Reports.

[14]  E. Schwarz,et al.  Osteoblast–osteoclast interactions , 2018, Connective tissue research.

[15]  Cheng Peng,et al.  Obacunone causes sustained expression of MKP‐1 thus inactivating p38 MAPK to suppress pro‐inflammatory mediators through intracellular MIF , 2018, Journal of cellular biochemistry.

[16]  L. Gesualdo,et al.  Inflammation induces osteoclast differentiation from peripheral mononuclear cells in chronic kidney disease patients: crosstalk between the immune and bone systems , 2018, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[17]  K. Yokota.  [Inflammation and osteoclasts]. , 2017, Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology.

[18]  Guo-Dong Zhang,et al.  Targeting Integrin-β1 Impedes Cytokine-Induced Osteoclast Differentiation: A Potential Pharmacological Intervention in Pathological Osteolysis , 2016 .

[19]  Bo Chen,et al.  Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation. , 2016, Life sciences.

[20]  L. McNamara,et al.  Differential β3 and β1 Integrin Expression in Bone Marrow and Cortical Bone of Estrogen Deficient Rats , 2015, Anatomical record.

[21]  B. Patil,et al.  Cytotoxicity of obacunone and obacunone glucoside in human prostate cancer cells involves Akt-mediated programmed cell death. , 2015, Toxicology.

[22]  B. Patil,et al.  Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by inhibiting the p38 MAPK signaling pathway in MCF-7 human breast adenocarcinoma cells. , 2014, Biochimie.

[23]  C. Panaroni,et al.  Mesenchymal Progenitors and the Osteoblast Lineage in Bone Marrow Hematopoietic Niches , 2014, Current Osteoporosis Reports.

[24]  S. Kook,et al.  Acteoside Suppresses RANKL-Mediated Osteoclastogenesis by Inhibiting c-Fos Induction and NF-κB Pathway and Attenuating ROS Production , 2013, PloS one.

[25]  R. Müller,et al.  Lentiviral-mediated integrin α5 expression in human adult mesenchymal stromal cells promotes bone repair in mouse cranial and long-bone defects. , 2012, Human gene therapy.

[26]  Jing Liu,et al.  C-Src-mediated RANKL-induced breast cancer cell migration by activation of the ERK and Akt pathway. , 2012, Oncology letters.

[27]  E. Cho,et al.  The effects of rosiglitazone on osteoblastic differentiation, osteoclast formation and bone resorption , 2012, Molecules and cells.

[28]  L. Xing,et al.  Src inhibitors in the treatment of metastatic bone disease: rationale and clinical data. , 2011, Clinical investigation.

[29]  T. Rachner,et al.  Osteoporosis: now and the future , 2011, The Lancet.

[30]  Xu Feng,et al.  Disorders of bone remodeling. , 2011, Annual review of pathology.

[31]  J. Guan.  Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer , 2010, IUBMB life.

[32]  Donald Gullberg,et al.  Integrins , 2009, Cell and Tissue Research.

[33]  M. Mullender,et al.  The Src Inhibitor AZD0530 Reversibly Inhibits the Formation and Activity of Human Osteoclasts , 2009, Molecular Cancer Research.

[34]  V. Brunton,et al.  Src and focal adhesion kinase as therapeutic targets in cancer. , 2008, Current opinion in pharmacology.

[35]  F. Aoudjit,et al.  α1β1 integrin and interleukin‐7 receptor up‐regulate the expression of RANKL in human T cells and enhance their osteoclastogenic function , 2008, Immunology.

[36]  S. Rodan,et al.  Involvement of αvβ3 integrins in osteoclast function , 2007, Journal of Bone and Mineral Metabolism.

[37]  Yoshiya Tanaka,et al.  Osteoblasts and osteoclasts in bone remodeling and inflammation. , 2005, Current drug targets. Inflammation and allergy.

[38]  Yoshiya Tanaka,et al.  β1 Integrin/Focal Adhesion Kinase-mediated Signaling Induces Intercellular Adhesion Molecule 1 and Receptor Activator of Nuclear Factor κB Ligand on Osteoblasts and Osteoclast Maturation* , 2003, Journal of Biological Chemistry.

[39]  Xu Feng,et al.  PYK2 and FAK in osteoclasts. , 2003, Frontiers in bioscience : a journal and virtual library.

[40]  Paul J. Williams,et al.  C-SRC tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis. , 2003, Cancer research.

[41]  C. Deal,et al.  Osteoporosis in elderly: prevention and treatment. , 2002, Clinics in geriatric medicine.

[42]  J. Heino,et al.  Diminished Callus Size and Cartilage Synthesis in α1β1 Integrin-Deficient Mice during Bone Fracture Healing , 2002 .

[43]  M. Poupon,et al.  Src kinase contributes to the metastatic spread of carcinoma cells , 2002, Oncogene.

[44]  Sakae Tanaka,et al.  c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption , 1996, Nature.

[45]  R. Baron,et al.  Osteoclasts express high levels of pp60c-src in association with intracellular membranes , 1992, The Journal of cell biology.