Relation of Adrenal Cortical Steroids to Antibody Release

Conclusions 1. The anamnestic reaction was produced by means of subcutaneously administered adrenal cortical steroids in oil to rabbits immunized against sheep erythrocytes. 2. Lymphocytes obtained from the appendix, thymus and mesenteric node of rabbits when injected intravenously into a normal rabbit circulate for a period of about 30 minutes only. 3. Lymphocytes obtained from the appendix, thymus and mesenteric node of rabbits immunized against sheep erythrocytes when injected intravenously into a normal rabbit do not release antibody under the conditions of the experimental method employed. 4. Adrenal cortical steroids administered to a normal rabbit which also receives lymphocytes intravenously from rabbits immunized against sheep erythrocytes do not induce a release of antibody from these cells while they are circulating according to the experimental method employed. The authors are indebted to the Upjohn Co., Kalamazoo, Mich., for 40 cc of the 80 cc of Lipo-Adrenal Cortex used in the experiment.