Numeric Investigation of Brain Tumor Influence on the Current Distributions During Transcranial Direct Current Stimulation

This study constructed a series of high-resolution realistic human-head models with brain tumors, and numerically investigated the influence of brain tumor's location and grade on the current distributions, under different electrode montages during tDCS. The threshold area and the peak current density were also derived and analyzed in the region of interest. The simulation result showed that it is safe to apply tDCS on the patients with brain tumors to treat their neuropsychiatric conditions and cancer pain caused by the tumor; although considerable changes of the current distributions are induced by the presence of a brain tumor. In addition, several observations on the global and local influences of tumor grade and possible edema have been made as well. These findings should be helpful for researchers and clinical doctors to treat patients with brain tumors. This study is also the first numerical study to fill in the gap of tDCS applications on the patients with brain tumors.

[1]  H. Fricke,et al.  The Electric Capacity of Tumors of the Breast , 1926 .

[2]  M. Hallett,et al.  A finite element analysis of the effect of electrode area and inter-electrode distance on the spatial distribution of the current density in tDCS , 2011, Journal of neural engineering.

[3]  R A Betensky,et al.  Tumor location and growth pattern correlate with genetic signature in oligodendroglial neoplasms. , 2001, Cancer research.

[4]  Mark W. Woolrich,et al.  Advances in functional and structural MR image analysis and implementation as FSL , 2004, NeuroImage.

[5]  Bin He,et al.  Neuromodulation for Brain Disorders: Challenges and Opportunities , 2013, IEEE Transactions on Biomedical Engineering.

[6]  Alvaro Pascual-Leone,et al.  Cognitive effects of repeated sessions of transcranial direct current stimulation in patients with depression , 2006, Depression and anxiety.

[7]  Alvaro Pascual-Leone,et al.  Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease , 2006, Journal of the Neurological Sciences.

[8]  Peng Wen,et al.  Effects of model complexity and tissue anisotropic conductivity on cortical modulation during transcranial direct current stimulation , 2012 .

[9]  M. Bikson,et al.  Transcranial current stimulation focality using disc and ring electrode configurations: FEM analysis , 2008, Journal of neural engineering.

[10]  Rafael V. Davalos,et al.  Electrical conductivity changes during irreversible electroporation treatment of brain cancer , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[11]  B. R. Pullan,et al.  The effects of low-level direct current therapy on a preclinical mammary carcinoma: tumour regression and systemic biochemical sequelae. , 1994, British Journal of Cancer.

[12]  Bin He,et al.  Magnetic-Resonance-Based Electrical Properties Tomography: A Review , 2014, IEEE Reviews in Biomedical Engineering.

[13]  David R. Wozny,et al.  The electrical conductivity of human cerebrospinal fluid at body temperature , 1997, IEEE Transactions on Biomedical Engineering.

[14]  C. Oji,et al.  Destruction of an advanced malignant tumour by direct electrical current-case report , 2010 .

[15]  L. Vodovnik,et al.  Tumor treatment by direct electric current-tumor temperature and pH, electrode material and configuration , 1993 .

[16]  R. Anderson,et al.  On Electrical Impedance Scanning - Principles and Simulations , 2000 .

[17]  D. Reato,et al.  Gyri-precise head model of transcranial direct current stimulation: Improved spatial focality using a ring electrode versus conventional rectangular pad , 2009, Brain Stimulation.

[18]  P. Turjanski,et al.  Ion transport in tumors under electrochemical treatment: in vivo, in vitro and in silico modeling. , 2007, Bioelectrochemistry.

[19]  F. H. Lopes da Silva,et al.  In vivo measurement of the brain and skull resistivities using an EIT-based method and the combined analysis of SEF/SEP data , 2003, IEEE Transactions on Biomedical Engineering.

[20]  Damijan Miklavčič,et al.  The feasibility of low level direct current electrotherapy for regional cancer treatment , 1993 .

[21]  Walter Paulus,et al.  Anodal transcranial direct current stimulation of the motor cortex ameliorates chronic pain and reduces short intracortical inhibition. , 2010, Journal of pain and symptom management.

[22]  Thom F. Oostendorp,et al.  The conductivity of the human skull: results of in vivo and in vitro measurements , 2000, IEEE Transactions on Biomedical Engineering.

[23]  D. B. Heppner,et al.  Considerations of quasi-stationarity in electrophysiological systems. , 1967, The Bulletin of mathematical biophysics.

[24]  Á. Pascual-Leone,et al.  Treatment of cancer pain with noninvasive brain stimulation. , 2007, Journal of pain and symptom management.

[25]  Tobias Voigt,et al.  Electrical Properties Tomography in the Human Brain at 1.5, 3, and 7T: A Comparison Study , 2014, Magnetic resonance in medicine.

[26]  Ahmedin Jemal,et al.  Childhood and adolescent cancer statistics, 2014 , 2014, CA: a cancer journal for clinicians.

[27]  Ron Kikinis,et al.  Adaptive, template moderated, spatially varying statistical classification , 2000, Medical Image Anal..

[28]  Rosalind J. Sadleir,et al.  Transcranial direct current stimulation (tDCS) in a realistic head model , 2010, NeuroImage.

[29]  D Maintz,et al.  Local treatment of hepatic metastases with low-level direct electric current: experimental results. , 2000, Scandinavian Journal of Gastroenterology.

[30]  M. Nitsche,et al.  Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation , 2000, The Journal of physiology.

[31]  R. Kikinis,et al.  Automated segmentation of MR images of brain tumors. , 2001, Radiology.

[32]  Warren M Grill,et al.  Analysis of the quasi-static approximation for calculating potentials generated by neural stimulation , 2008, Journal of neural engineering.

[33]  Walter Paulus,et al.  Transcranial Direct Current Stimulation Over Somatosensory Cortex Decreases ExperimentallyInduced Acute Pain Perception , 2008, The Clinical journal of pain.

[34]  R. W. Lau,et al.  The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz. , 1996, Physics in medicine and biology.

[35]  S. Dokos,et al.  A computational model of direct brain excitation induced by electroconvulsive therapy: Comparison among three conventional electrode placements , 2012, Brain Stimulation.

[36]  Tobias A Mattei,et al.  The effects of alternating electric fields in glioblastoma: current evidence on therapeutic mechanisms and clinical outcomes. , 2015, Neurosurgical focus.

[37]  L. Cohen,et al.  Transcranial direct current stimulation: State of the art 2008 , 2008, Brain Stimulation.

[38]  Luca Cucullo,et al.  Very low intensity alternating current decreases cell proliferation , 2005, Glia.

[39]  P. Nicholson,et al.  Specific impedance of cerebral white matter. , 1965, Experimental neurology.

[40]  L. Vodovnik,et al.  Tumor Treatment by Direct Electric Current: Computation of Electric Current and Power Density Distribution , 1997 .

[41]  E. Dekel,et al.  Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors , 2007, Proceedings of the National Academy of Sciences.

[42]  Olaf Dössel,et al.  Determination of Electric Conductivity and Local SAR Via B1 Mapping , 2009, IEEE Transactions on Medical Imaging.

[43]  Socrates Dokos,et al.  A computational modelling study of transcranial direct current stimulation montages used in depression , 2014, NeuroImage.

[44]  S. Dokos,et al.  A review of computational models of transcranial electrical stimulation. , 2013, Critical reviews in biomedical engineering.

[45]  Walter Paulus,et al.  The use of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) to relieve pain , 2008, Brain Stimulation.

[46]  G.D. O'Clock,et al.  Potential uses of low-level direct current electrotherapy for the treatment of cancer , 1993, Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ.

[47]  Ryan J Halter,et al.  Passive bioelectrical properties for assessing high‐ and low‐grade prostate adenocarcinoma , 2011, The Prostate.

[48]  M. Chesler.  Regulation and modulation of pH in the brain. , 2003, Physiological reviews.

[49]  A. Antal,et al.  Safety aspects of transcranial direct current stimulation concerning healthy subjects and patients , 2007, Brain Research Bulletin.

[50]  D Maintz,et al.  Experimental low-level direct current therapy in liver metastases: influence of polarity and current dose. , 2000, Bioelectromagnetics.

[51]  J. Fermaglich.  Electric Fields of the Brain: The Neurophysics of EEG , 1982 .

[52]  M. Bikson,et al.  Electrodes for high-definition transcutaneous DC stimulation for applications in drug delivery and electrotherapy, including tDCS , 2010, Journal of Neuroscience Methods.

[53]  Mae-Wan Ho,et al.  Bioenergetics and Biocommunication , 1996 .

[54]  L. Geddes,et al.  The specific resistance of biological material—A compendium of data for the biomedical engineer and physiologist , 1967, Medical and biological engineering.

[55]  Jin Keun Seo,et al.  Recent Progress and Future Challenges in MR Electric Properties Tomography , 2013, Comput. Math. Methods Medicine.

[56]  S. Edelman,et al.  Human Brain Mapping 6:316–328(1998) � A Sequence of Object-Processing Stages Revealed by fMRI in the Human Occipital Lobe , 2022 .

[57]  D. Stuss,et al.  Humour appreciation: a role of the right frontal lobe. , 1999, Brain : a journal of neurology.

[58]  D Miklavcic,et al.  Inhibition of SA-1 tumor growth in mice by human leukocyte interferon alpha combined with low-level direct current. , 1990, Molecular biotherapy.

[59]  M. Nitsche,et al.  Safety limits of cathodal transcranial direct current stimulation in rats , 2009, Clinical Neurophysiology.

[60]  B. Scheithauer,et al.  The New WHO Classification of Brain Tumours , 1993, Brain pathology.

[61]  D. Absolom,et al.  Effect of low level direct current on in vivo tumor growth in hamsters. , 1985, Cancer research.

[62]  S. Bauer,et al.  A survey of MRI-based medical image analysis for brain tumor studies , 2013, Physics in medicine and biology.

[63]  Yifan Chen,et al.  Effect of Lesion Morphology on Microwave Signature in 2-D Ultra-Wideband Breast Imaging , 2008, IEEE Transactions on Biomedical Engineering.

[64]  Zhenyu Guo,et al.  A review of electrical impedance techniques for breast cancer detection. , 2003, Medical engineering & physics.

[65]  C Gabriel,et al.  The dielectric properties of biological tissues: I. Literature survey. , 1996, Physics in medicine and biology.

[66]  Peng Wen,et al.  Assessment of electric field distribution in anisotropic cortical and subcortical regions under the influence of tDCS , 2014, Bioelectromagnetics.

[67]  Roger J Ordidge,et al.  Anodal transcranial direct current stimulation increases brain intracellular pH and modulates bioenergetics. , 2013, The international journal of neuropsychopharmacology.

[68]  M. Snoj,et al.  Electrochemotherapy of tumours , 2006, Current oncology.

[69]  Alessia Paglialonga,et al.  Transcranial Direct Current Stimulation: Estimation of the Electric Field and of the Current Density in an Anatomical Human Head Model , 2011, IEEE Transactions on Biomedical Engineering.

[70]  K. Foster,et al.  Dielectric Properties of VX-2 Carcinoma Versus Normal Liver Tissue , 1986, IEEE Transactions on Biomedical Engineering.

[71]  Faisal Mahmood,et al.  Preclinical validation of electrochemotherapy as an effective treatment for brain tumors. , 2011, Cancer research.

[72]  Ohin Kwon,et al.  Numerical Simulations of MREIT Conductivity Imaging for Brain Tumor Detection , 2013, Comput. Math. Methods Medicine.

[73]  Peng Wen,et al.  Numerical investigation of white matter anisotropic conductivity in defining current distribution under tDCS , 2013, Comput. Methods Programs Biomed..

[74]  Alan C. Evans,et al.  BrainWeb: Online Interface to a 3D MRI Simulated Brain Database , 1997 .

[75]  Colleen Loo,et al.  Transcranial direct current stimulation influences probabilistic association learning in schizophrenia , 2011, Schizophrenia Research.

[76]  Li Li,et al.  Characterization of the mechanisms of electrochemotherapy in an in vitro model for human cervical cancer. , 2005, International journal of oncology.

[77]  F. Fregni,et al.  Noninvasive Brain Stimulation with Low-Intensity Electrical Currents: Putative Mechanisms of Action for Direct and Alternating Current Stimulation , 2010, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.