Enhancement of muscle cell glucose uptake by medicinal plant species of Canada's native populations is mediated by a common, metformin-like mechanism.

[1]  Suna Kim,et al.  The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. , 2008, Biochemical and biophysical research communications.

[2]  B. Kola.  Role of AMP-Activated Protein Kinase in the Control of Appetite , 2008, Journal of neuroendocrinology.

[3]  B. Furman,et al.  Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice , 2008, British journal of pharmacology.

[4]  P. Haddad,et al.  Antioxidant and mitochondrial protective effects of silibinin in cold preservation-warm reperfusion liver injury. , 2008, Journal of ethnopharmacology.

[5]  M. Prentki,et al.  Antidiabetic Activity of Nigella sativa. Seed Extract in Cultured Pancreatic β-cells, Skeletal Muscle Cells, and Adipocytes , 2008 .

[6]  P. Misra.  AMP activated protein kinase: a next generation target for total metabolic control , 2008, Expert opinion on therapeutic targets.

[7]  Catherine H. Yu,et al.  Type 2 diabetes and impaired glucose tolerance in aboriginal populations: a global perspective. , 2007, Diabetes research and clinical practice.

[8]  Hui-yu Liu,et al.  Epigallocatechin-3-gallate (EGCG), A Green Tea Polyphenol, Suppresses Hepatic Gluconeogenesis through 5′-AMP-activated Protein Kinase* , 2007, Journal of Biological Chemistry.

[9]  C. Matar,et al.  Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes. , 2007, Canadian journal of physiology and pharmacology.

[10]  Y. Lee,et al.  CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells. , 2007, Biochemical and biophysical research communications.

[11]  F. Wong-Staal,et al.  Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase. , 2007, The Journal of endocrinology.

[12]  W. Winder,et al.  Cellular energy sensing and signaling by AMP-activated protein kinase , 2007, Cell Biochemistry and Biophysics.

[13]  J. Wojtaszewski,et al.  Role of Akt substrate of 160 kDa in insulin-stimulated and contraction-stimulated glucose transport. , 2007, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[14]  J. Ha,et al.  Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase , 2007, Experimental & Molecular Medicine.

[15]  F. Thong,et al.  The Rab GTPase-Activating Protein AS160 Integrates Akt, Protein Kinase C, and AMP-Activated Protein Kinase Signals Regulating GLUT4 Traffic , 2007, Diabetes.

[16]  M. Prentki,et al.  Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait. , 2006, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[17]  M. Prentki,et al.  Selected plant species from the Cree pharmacopoeia of northern Quebec possess anti-diabetic potential. , 2006, Canadian journal of physiology and pharmacology.

[18]  Mengwei Zang,et al.  Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice , 2006, Diabetes.

[19]  D. James,et al.  Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States , 2006, Diabetes.

[20]  G. Shulman,et al.  The role of AMP‐activated protein kinase in mitochondrial biogenesis , 2006, The Journal of physiology.

[21]  J. Bernatonienė,et al.  The effect of flavonoids on rat heart mitochondrial function. , 2006, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[22]  C. Leduc,et al.  Plants used by the Cree Nation of Eeyou Istchee (Quebec, Canada) for the treatment of diabetes: A novel approach in quantitative ethnobotany. , 2006, Journal of ethnopharmacology.

[23]  Mark Hargreaves,et al.  EXERCISE AND SKELETAL MUSCLE GLUCOSE TRANSPORTER 4 EXPRESSION: MOLECULAR MECHANISMS , 2006, Clinical and experimental pharmacology & physiology.

[24]  J. Ha,et al.  Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. , 2005, Biochemical and biophysical research communications.

[25]  B. Lyoussi,et al.  Antidiabetic Plants of North Africa and the Middle East , 2005 .

[26]  A. C. Santos,et al.  The interaction of flavonoids with mitochondria: effects on energetic processes. , 2005, Chemico-biological interactions.

[27]  J. Zierath,et al.  Sending the signal: molecular mechanisms regulating glucose uptake. , 2004, Medicine and science in sports and exercise.

[28]  S. Del Prato,et al.  Reducing insulin resistance with metformin: the evidence today. , 2003, Diabetes & metabolism.

[29]  A. Klip,et al.  GLUT4 activation: thoughts on possible mechanisms. , 2003, Acta physiologica Scandinavica.

[30]  R. Balcarcel,et al.  24-well plate spectrophotometric assay for preliminary screening of metabolic activity. , 2003, Assay and drug development technologies.

[31]  Gideon Maxwell Polya,et al.  Biochemical Targets of Plant Bioactive Compounds: A Pharmacological Reference Guide to Sites of Action and Biological Effects , 2003 .

[32]  G. Rutter,et al.  Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. , 2003, The Biochemical journal.

[33]  Robert J Gillies,et al.  Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors. , 2003, Neoplasia.

[34]  Margaret S. Wu,et al.  Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.

[35]  L. Witters.  The blooming of the French lilac. , 2001, The Journal of clinical investigation.

[36]  W. Winder.  Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle. , 2001, Journal of applied physiology.

[37]  J. Tillement,et al.  Curcumin induces the mitochondrial permeability transition pore mediated by membrane protein thiol oxidation , 2001, FEBS letters.

[38]  T. K. Young,et al.  Type 2 diabetes mellitus in Canada's first nations: status of an epidemic in progress. , 2000, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[39]  F. Ismail-Beigi,et al.  Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport. , 2000, Archives of biochemistry and biophysics.

[40]  M. Owen,et al.  Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. , 2000, The Biochemical journal.

[41]  M. Rigoulet,et al.  Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I* , 2000, The Journal of Biological Chemistry.

[42]  F. Ismail-Beigi,et al.  Dual Control of glut1 Glucose Transporter Gene Expression by Hypoxia and by Inhibition of Oxidative Phosphorylation* , 1997, The Journal of Biological Chemistry.

[43]  R. Kahl,et al.  Enhancement of glycolysis and CO2 formation from glycerol by hydroxyl radical scavengers in rat hepatocytes. , 1996, Research communications in molecular pathology and pharmacology.

[44]  R. Marles,et al.  Antidiabetic plants and their active constituents. , 1995, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[45]  F. Ismail-Beigi,et al.  Induction of GLUT1 mRNA in response to inhibition of oxidative phosphorylation. , 1993, The American journal of physiology.

[46]  A. Klip,et al.  Mechanisms of adaptation of glucose transporters to changes in the oxidative chain of muscle and fat cells. , 1993, The American journal of physiology.

[47]  Lawrence A Leiter,et al.  Stimulation of hexose transport by metformin in L6 muscle cells in culture. , 1992, Endocrinology.

[48]  A. Marette,et al.  Acute and chronic signals controlling glucose transport in skeletal muscle , 1992, Journal of cellular biochemistry.

[49]  H. Towbin,et al.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[50]  M. Eggstein,et al.  Lactic acidosis in biguanide-treated diabetics , 1978, Diabetologia.

[51]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.

[52]  J V Maizel,et al.  Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. , 1967, Biochemical and biophysical research communications.

[53]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[54]  B. Viollet,et al.  Targeting the AMPK pathway for the treatment of Type 2 diabetes. , 2009, Frontiers in bioscience.

[55]  S. McGee,et al.  AMPK and transcriptional regulation. , 2008, Frontiers in bioscience : a journal and virtual library.

[56]  J. Torrie,et al.  Cree Diabetes Information System (CDIS) 2007 Annual Report Cree Diabetes Information System (CDIS) 2007 Annual Report , 2008 .

[57]  N. Fujii,et al.  Symposium 1 : Exercise signalling pathways controlling fuel oxidation during and after exercise Regulation of glucose transport by the AMP-activated protein kinase , 2004 .

[58]  N. Fujii,et al.  Activation of AMP-Activated Protein Kinase as a Unifying Coupling Mechanism , 2000 .

[59]  H. Lardy,et al.  [15] Isolation of liver or kidney mitochondria , 1967 .