Clinical features of acute anterior uveitis.

We studied the clinical features and prognosis of 73 patients with HLA-B27 positive and 71 patients with HLA-B27 negative acute anterior uveitis using computer analysis of more than 50 variables per patient. The patients with HLA-B27 positive acute anterior uveitis showed the following characteristics which were significantly different from patients with HLA-B27 negative acute anterior uveitis: younger age at onset; high male to female ratio; frequent unilateral alternating eye involvement; severe ocular symptoms during activity, such as presence of fibrin in the anterior chamber; absence of mutton fat keratic precipitates; high incidence of ocular complications; and frequent association with seronegative spondyloarthropathies. Despite the difference of disease severity and incidence of complications, the long-term visual outcome did not differ significantly between the two groups. No distinctions were observed when patients with HLA-B27 positive acute anterior uveitis were subdivided according to sex or the presence of ankylosing spondylitis. HLA-B27 positive acute anterior uveitis formed a distinct clinical entity associated with serious prognosis as compared to HLA-B27 negative acute anterior uveitis.

[1]  M. Hogan,et al.  Signs and symptoms of uveitis. II. Classification of the posterior manifestations of uveitis. , 1959, American journal of ophthalmology.

[2]  D. Harrington.  The pathogenesis of the glaucoma field: clinical evidence that circulatory insufficiency in the optic nerve is the primary cause of visual field loss in glaucoma. , 1959, American journal of ophthalmology.

[3]  M. Nahir,et al.  Anterior uveitis in ankylosing spondylitis: a histocompatibility study. , 1979, Annals of ophthalmology.

[4]  P. D. de Jong,et al.  Possible ankylosing spondylitis in acute anterior uveitis. , 1983, British journal of rheumatology.

[5]  M. Hogan,et al.  Signs and symptoms of uveitis. I. Anterior uveitis. , 1959, American journal of ophthalmology.

[6]  M. Saari,et al.  Clinical characteristics of familial acute anterior uveitis. , 1977, Canadian Journal of Ophthalmology-journal Canadien D Ophtalmologie.

[7]  N. Ehlers,et al.  Letter: HL-A27 in acute and chronic uveitis. , 1974, Lancet.

[8]  K. Berg,et al.  Ankylosing spondylitis is part of a multifactorial syndrome: hereditary multifocal relapsing inflammation (HEMRI) , 1984, Clinical genetics.

[9]  B. M. Jongh,et al.  The risk of developing ankylosing spondylitis in HLA-B27 positive individuals. A comparison of relatives of spondylitis patients with the general population. , 1984, Arthritis and rheumatism.

[10]  D. A. Brewerton,et al.  Acute anterior uveitis and HL-A 27. , 1973, Lancet.

[11]  A. Ebringer,et al.  Ankylosing spondylitis: klebsiella and HL-A B27. , 1977, Rheumatology and rehabilitation.

[12]  W. Braun,et al.  Comparison of clinical features in HLA-B27 positive and negative patients with ankylosing spondylitis. , 1977, Arthritis and rheumatism.

[13]  J. C. Woodrow,et al.  HL-A 27 and acute anterior uveitis. , 1975, The British journal of ophthalmology.

[14]  D. Wakefield,et al.  CLINICAL FEATURES OF HLA‐B27 ANTERIOR UVEITIS , 1984 .

[15]  J. Edmonds,et al.  Possible role of enteric organisms in the pathogenesis of ankylosing spondylitis and other seronegative arthropathies , 1983, Infection and immunity.