Detecting neuronal currents with MRI: A human study

Recently developed neuronal current magnetic resonance imaging aims to directly detect neuronal currents associated with brain activity, but controversial results have been reported in different studies on human subjects. Although there is no dispute that local neuronal currents produce weak transient magnetic fields that would attenuate local MR signal intensity, there is not yet consensus as to whether this attenuation is detectable with present magnetic resonance imaging techniques. This study investigates the magnitude of neuronal current‐induced signal attenuation in human visual cortex.

[1]  Manbir Singh Sensitivity of MR phase shift to detect evoked neuromagnetic fields inside the head , 1992 .

[2]  D. Heeger,et al.  Linear Systems Analysis of Functional Magnetic Resonance Imaging in Human V1 , 1996, The Journal of Neuroscience.

[3]  M. Livingstone,et al.  Neuronal correlates of visibility and invisibility in the primate visual system , 1998, Nature Neuroscience.

[4]  A. Leventhal,et al.  Signal timing across the macaque visual system. , 1998, Journal of neurophysiology.

[5]  K. Iramina,et al.  Neuronal current distribution imaging using magnetic resonance , 1999, IEEE International Magnetics Conference.

[6]  J. Xiong,et al.  Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging , 2003, Human brain mapping.

[7]  Susana Martinez-Conde,et al.  The spatial and temporal effects of lateral inhibitory networks and their relevance to the visibility of spatiotemporal edges , 2004, Neurocomputing.

[8]  Bruno Maraviglia,et al.  Combination of BOLD-fMRI and VEP recordings for spin-echo MRI detection of primary magnetic effects caused by neuronal currents. , 2004, Magnetic resonance imaging.

[9]  Jeff H. Duyn,et al.  Hunting for neuronal currents: absence of rapid MRI signal changes during visual-evoked response , 2004, NeuroImage.

[10]  Li Sze Chow,et al.  Investigation of MR signal modulation due to magnetic fields from neuronal currents in the adult human optic nerve and visual cortex. , 2006, Magnetic resonance imaging.

[11]  Daniel Brandeis,et al.  Heart beats brain: The problem of detecting alpha waves by neuronal current imaging in joint EEG–MRI experiments , 2007, NeuroImage.

[12]  Laura M Parkes,et al.  Inability to directly detect magnetic field changes associated with neuronal activity , 2007, Magnetic resonance in medicine.

[13]  J. Gore,et al.  Failure to direct detect magnetic field dephasing corresponding to ERP generation. , 2008, Magnetic resonance imaging.

[14]  M. Paley,et al.  Comparison of BOLD and direct‐MR neuronal detection (DND) in the human visual cortex at 3T , 2008, Magnetic resonance in medicine.

[15]  Michele Migliore,et al.  Realistic simulations of neuronal activity: A contribution to the debate on direct detection of neuronal currents by MRI , 2008, NeuroImage.

[16]  J. Xiong,et al.  Direct MRI mapping of neuronal activity evoked by electrical stimulation of the median nerve at the right wrist , 2009, Magnetic resonance in medicine.

[17]  Jia-Hong Gao,et al.  Physiologically evoked neuronal current MRI in a bloodless turtle brain: Detectable or not? , 2009, NeuroImage.

[18]  Jianfeng Gao,et al.  Modeling magnitude and phase neuronal current MRI signal dependence on echo time , 2010, Magnetic resonance in medicine.

[19]  A. Wilkins,et al.  fMRI evidence that precision ophthalmic tints reduce cortical hyperactivation in migraine , 2011, Cephalalgia : an international journal of headache.

[20]  Jianfeng Gao,et al.  Detection of neuronal current MRI in human without BOLD contamination , 2011, Magnetic resonance in medicine.

[21]  Bin Chen,et al.  Modeling neuronal current MRI signal with human neuron , 2011, Magnetic resonance in medicine.