Absolute lymphocyte count recovery at 1 month after transplantation predicts favorable outcomes of patients with hepatocellular carcinoma

Absolute lymphocyte count (ALC) and the recovery of ALC after treatment have been identified as a prognostic biomarker for several malignancies. In this study, we aimed to investigate the prognostic role of peritransplant ALC and ALC recovery after liver transplantation (LT) in hepatocellular carcinoma (HCC) patients.

[1]  M. Zhang,et al.  Genetic Polymorphism of Interferon Regulatory Factor 5 (IRF5) Correlates with Allograft Acute Rejection of Liver Transplantation , 2014, PloS one.

[2]  D. Altshuler,et al.  Peritransplant absolute lymphocyte count as a predictive factor for advanced recurrence of hepatitis C after liver transplantation , 2014, Hepatology.

[3]  M. Abouljoud,et al.  Peritransplant Lymphopenia Is a Novel Prognostic Factor in Recurrence of Hepatocellular Carcinoma After Liver Transplantation , 2013, Transplantation.

[4]  M. Álvarez-Mon,et al.  Defective thymopoiesis and poor peripheral homeostatic replenishment of T-helper cells cause T-cell lymphopenia in cirrhosis. , 2013, Journal of hepatology.

[5]  T. Wen,et al.  Scoring Selection Criteria Including Total Tumour Volume and Pretransplant Percentage of Lymphocytes to Predict Recurrence of Hepatocellular Carcinoma after Liver Transplantation , 2013, PloS one.

[6]  J. Jia,et al.  Update on epidemiology of hepatitis B and C in China , 2013, Journal of gastroenterology and hepatology.

[7]  Jiyuan Zhang,et al.  Impairment of CD4+ cytotoxic T cells predicts poor survival and high recurrence rates in patients with hepatocellular carcinoma , 2013, Hepatology.

[8]  H. Friess,et al.  Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells , 2013, Hepatology.

[9]  T. Kagaya,et al.  Enhancement of tumor‐associated antigen‐specific T cell responses by radiofrequency ablation of hepatocellular carcinoma , 2013, Hepatology.

[10]  T. Chiba,et al.  Reduction of Immunocompetent T Cells Followed by Prolonged Lymphopenia in Severe Sepsis in the Elderly* , 2013, Critical care medicine.

[11]  E. Plimack,et al.  Lymphopenia is an independent predictor of inferior outcome in clear cell renal carcinoma. , 2013, The Journal of urology.

[12]  S. Gitto,et al.  Influence of Age and Gender Before and After Liver Transplantation , 2013, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[13]  T. Luedde,et al.  Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer , 2012, Gut.

[14]  M. Correia,et al.  The impact of nutrition on cirrhotic patients awaiting liver transplantation , 2010, Current opinion in clinical nutrition and metabolic care.

[15]  E. Paz-Artal,et al.  Pretransplant lymphocyte count predicts the incidence of infection during the first two years after liver transplantation , 2009, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[16]  J. Blay,et al.  Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas. , 2009, Cancer research.

[17]  Johnny C. Hong,et al.  Recurrence of hepatocellular carcinoma following liver transplantation: a review of preoperative and postoperative prognostic indicators. , 2008, Archives of surgery.

[18]  S. Vowler,et al.  Tumour lymphocytic infiltrate and recurrence of hepatocellular carcinoma following liver transplantation. , 2006, Journal of hepatology.

[19]  T. Liang,et al.  Prevention of hepatitis B recurrence after liver transplantation using lamivudine or lamivudine combined with hepatitis B Immunoglobulin prophylaxis , 2006, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[20]  R. Mesa,et al.  Absolute lymphocyte count recovery after induction chemotherapy predicts superior survival in acute myelogenous leukemia , 2005, Leukemia.

[21]  B. van Damme,et al.  FTY720, an immunosuppressant that alters lymphocyte trafficking, abrogates chronic rejection in combination with cyclosporine A , 2003, Transplantation.

[22]  Santhosh K. P. Kumar,et al.  Early lymphocyte recovery is a predictive factor for prolonged survival after autologous hematopoietic stem cell transplantation for acute myelogenous leukemia , 2002, Leukemia.

[23]  ndrea,et al.  Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. , 1996, The New England journal of medicine.

[24]  Roger Williams,et al.  MALNUTRITION AND IMMUNO-INCOMPETENCE IN PATIENTS WITH LIVER DISEASE , 1980, The Lancet.

[25]  L. Ose.  L.D.L. AND TOTAL CHOLESTEROL IN CORD-BLOOD SCREENING FOR FAMILIAL HYPERCHOLESTEROLÆMIA , 1975, The Lancet.

[26]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.