Silver Nanoparticles: Synthesis and Application for Nanomedicine

Over the past few decades, metal nanoparticles less than 100 nm in diameter have made a substantial impact across diverse biomedical applications, such as diagnostic and medical devices, for personalized healthcare practice. In particular, silver nanoparticles (AgNPs) have great potential in a broad range of applications as antimicrobial agents, biomedical device coatings, drug-delivery carriers, imaging probes, and diagnostic and optoelectronic platforms, since they have discrete physical and optical properties and biochemical functionality tailored by diverse size- and shape-controlled AgNPs. In this review, we aimed to present major routes of synthesis of AgNPs, including physical, chemical, and biological synthesis processes, along with discrete physiochemical characteristics of AgNPs. We also discuss the underlying intricate molecular mechanisms behind their plasmonic properties on mono/bimetallic structures, potential cellular/microbial cytotoxicity, and optoelectronic property. Lastly, we conclude this review with a summary of current applications of AgNPs in nanoscience and nanomedicine and discuss their future perspectives in these areas.

[1]  Homan Kang,et al.  Near‐Infrared SERS Nanoprobes with Plasmonic Au/Ag Hollow‐Shell Assemblies for In Vivo Multiplex Detection , 2013 .

[2]  J. West,et al.  Immunotargeted nanoshells for integrated cancer imaging and therapy. , 2005, Nano letters.

[3]  S. Gurunathan,et al.  Cytotoxicity of Biologically Synthesized Silver Nanoparticles in MDA-MB-231 Human Breast Cancer Cells , 2013, BioMed research international.

[4]  Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications , 2018, Applied Sciences.

[5]  Jae Hyun Kim,et al.  Silver nanoparticle-embedded graphene oxide-methotrexate for targeted cancer treatment. , 2017, Colloids and surfaces. B, Biointerfaces.

[6]  C. Granqvist,et al.  Bacteria as workers in the living factory: metal-accumulating bacteria and their potential for materials science. , 2001, Trends in biotechnology.

[7]  Theresa M Reineke,et al.  Theranostics: combining imaging and therapy. , 2011, Bioconjugate chemistry.

[8]  Ignacy Gryczynski,et al.  Metal-enhanced fluorescence: an emerging tool in biotechnology. , 2005, Current opinion in biotechnology.

[9]  U. Landman,et al.  Ultrastable silver nanoparticles , 2013, Nature.

[10]  Younan Xia,et al.  Polyol Synthesis of Uniform Silver Nanowires: A Plausible Growth Mechanism and the Supporting Evidence , 2003 .

[11]  Junaidi,et al.  High-Performance Silver Nanowire Film on Flexible Substrate Prepared by Meyer-rod Coating , 2017 .

[12]  R. Prucek,et al.  Antifungal effects of copper and silver nanoparticles against white and brown-rot fungi , 2017, Journal of Materials Science.

[13]  Chen-Sheng Yeh,et al.  Laser ablation method: use of surfactants to form the dispersed Ag nanoparticles , 2002 .

[14]  A. Agrawal,et al.  Anticancer activity of Moringa oleifera mediated silver nanoparticles on human cervical carcinoma cells by apoptosis induction. , 2014, Colloids and surfaces. B, Biointerfaces.

[15]  S. Iravani,et al.  Synthesis of silver nanoparticles: chemical, physical and biological methods , 2014, Research in pharmaceutical sciences.

[16]  George John,et al.  Silver-nanoparticle-embedded antimicrobial paints based on vegetable oil. , 2008, Nature materials.

[17]  Jhantu Kumar Saha,et al.  Broadband enhancement in thin-film amorphous silicon solar cells enabled by nucleated silver nanoparticles. , 2012, Nano letters.

[18]  X. Qiao,et al.  Synthesis and electrical properties of uniform silver nanoparticles for electronic applications , 2009 .

[19]  B. Guan,et al.  Fungus-Mediated Green Synthesis of Silver Nanoparticles Using Aspergillus terreus , 2011, International journal of molecular sciences.

[20]  D. Evanoff,et al.  Synthesis and optical properties of silver nanoparticles and arrays. , 2005, Chemphyschem : a European journal of chemical physics and physical chemistry.

[21]  H. Atwater,et al.  Plasmonics for improved photovoltaic devices. , 2010, Nature materials.

[22]  B. Lee,et al.  Versatile surface plasmon resonance of carbon-dot-supported silver nanoparticles in polymer optoelectronic devices , 2013, Nature Photonics.

[23]  K. Rajendran,et al.  Clinically Approved Drugs against CNS Diseases as Potential Therapeutic Agents To Target Brain-Eating Amoebae. , 2018, ACS chemical neuroscience.

[24]  Jie Zheng,et al.  Antibacterial Activity of Silver Nanoparticles: Structural Effects , 2018, Advanced healthcare materials.

[25]  E. Rauwel,et al.  A Review on the Green Synthesis of Silver Nanoparticles and Their Morphologies Studied via TEM , 2015 .

[26]  Shakeel Ahmed,et al.  Silver nanoparticles: One Pot Green Synthesis Using Terminalia arjuna Extract for Biological Application , 2015 .

[27]  Ho-Sub Kim,et al.  Dual Functionalized Freestanding TiO2 Nanotube Arrays Coated with Ag Nanoparticles and Carbon Materials for Dye-Sensitized Solar Cells , 2017 .

[28]  Albert Duschl,et al.  Shape matters: effects of silver nanospheres and wires on human alveolar epithelial cells , 2011, Particle and Fibre Toxicology.

[29]  M. Meneghetti,et al.  Laser ablation synthesis in solution and size manipulation of noble metal nanoparticles. , 2009, Physical chemistry chemical physics : PCCP.

[30]  Salmiati,et al.  A Review of Silver Nanoparticles: Research Trends, Global Consumption, Synthesis, Properties, and Future Challenges , 2017 .

[31]  V. Balakumar,et al.  Nanosilver for selective and sensitive sensing of saturnism , 2017 .

[32]  Kimberly Hamad-Schifferli,et al.  Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses. , 2015, Lab on a chip.

[33]  M. El-Sayed,et al.  Dependence of the enhanced optical scattering efficiency relative to that of absorption for gold metal nanorods on aspect ratio, size, end-cap shape, and medium refractive index. , 2005, The journal of physical chemistry. B.

[34]  Ruchi Yadav,et al.  Biogenic synthesis of silver nanoparticles and their synergistic effect with antibiotics: a study against gram-positive and gram-negative bacteria. , 2010, Nanomedicine : nanotechnology, biology, and medicine.

[35]  Matthew Boyles,et al.  The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types , 2015, Journal of Nanobiotechnology.

[36]  B. Sreedhar,et al.  Green synthesis, characterization of gold and silver nanoparticles and their potential application for cancer therapeutics. , 2015, Materials science & engineering. C, Materials for biological applications.

[37]  K. A. El-Nour,et al.  Synthesis and applications of silver nanoparticles , 2010 .

[38]  R. Chandra,et al.  Role of gold and silver nanoparticles in cancer nano-medicine , 2018, Artificial cells, nanomedicine, and biotechnology.

[39]  Younan Xia,et al.  Shape-Controlled Synthesis of Gold and Silver Nanoparticles , 2002, Science.

[40]  Alexandru Mihai Grumezescu,et al.  Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview , 2018, Nanomaterials.

[41]  S. Okabe,et al.  In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cells. , 2009, Environmental science & technology.

[42]  J. Turkevich,et al.  Palladium: Preparation and Catalytic Properties of Particles of Uniform Size , 1970, Science.

[43]  Bong-Hyun Jun,et al.  Ag Nanoparticle–Functionalized Open-Ended Freestanding TiO2 Nanotube Arrays with a Scattering Layer for Improved Energy Conversion Efficiency in Dye-Sensitized Solar Cells , 2016, Nanomaterials.

[44]  Paolo Prosposito,et al.  Hydrophilic silver nanoparticles with tunable optical properties: application for the detection of heavy metals in water , 2016, Beilstein journal of nanotechnology.

[45]  Tikam Chand Dakal,et al.  Mechanistic Basis of Antimicrobial Actions of Silver Nanoparticles , 2016, Frontiers in microbiology.

[46]  H. Sharghi,et al.  The effect of charge at the surface of silver nanoparticles on antimicrobial activity against gram-positive and gram-negative bacteria: a preliminary study , 2015 .

[47]  G. Southam,et al.  Biosynthesis of silver nanoparticles by filamentous cyanobacteria from a silver(I) nitrate complex. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[48]  H. Chiang,et al.  Near infrared surface-enhanced Raman scattering based on star-shaped gold/silver nanoparticles and hyperbolic metamaterial , 2017, Scientific Reports.

[49]  Sudhakar R. Sainkar,et al.  Fungus-mediated synthesis of silver nanoparticles and their immobilization in the mycelial matrix: a novel biological approach to nanoparticle synthesis , 2001 .

[50]  S. Gurunathan,et al.  Biosynthesis of silver nanocrystals by Bacillus licheniformis. , 2008, Colloids and surfaces. B, Biointerfaces.

[51]  Younan Xia,et al.  Seed-Mediated Growth of Colloidal Metal Nanocrystals. , 2017, Angewandte Chemie.

[52]  J. Jung,et al.  Metal nanoparticle generation using a small ceramic heater with a local heating area , 2006 .

[53]  H. Autrup,et al.  Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549 , 2011, Archives of Toxicology.

[54]  Toshiki Tsubota,et al.  Effect of core@shell (Au@Ag) nanostructure on surface plasmon-induced photocatalytic activity under visible light irradiation , 2017 .

[55]  Sang Hun Lee,et al.  Gold-silver bimetallic nanoparticles with a Raman labeling chemical assembled on silica nanoparticles as an internal-standard-containing nanoprobe , 2019, Journal of Alloys and Compounds.

[56]  R. V. Van Duyne,et al.  A nanoscale optical biosensor: sensitivity and selectivity of an approach based on the localized surface plasmon resonance spectroscopy of triangular silver nanoparticles. , 2002, Journal of the American Chemical Society.

[57]  Sang Hun Lee,et al.  Highly sensitive and reliable SERS probes based on nanogap control of a Au–Ag alloy on silica nanoparticles , 2017 .

[58]  M. Jeyaraj,et al.  Biogenic silver nanoparticles for cancer treatment: an experimental report. , 2013, Colloids and surfaces. B, Biointerfaces.

[59]  Carsten Sönnichsen,et al.  A molecular ruler based on plasmon coupling of single gold and silver nanoparticles , 2005, Nature Biotechnology.

[60]  M. Moskovits,et al.  Hot spots in silver nanowire bundles for surface-enhanced Raman spectroscopy. , 2006, Journal of the American Chemical Society.

[61]  E. Spiecker,et al.  Synthesis of silver nanoparticle necklaces without explicit addition of reducing or templating agents. , 2012, Chemical communications.

[62]  Ya‐Wen Zhang,et al.  Shape control of bimetallic nanocatalysts through well-designed colloidal chemistry approaches. , 2012, Chemical Society reviews.

[63]  D. Gray,et al.  Bactericidal paper impregnated with silver nanoparticles for point-of-use water treatment. , 2011, Environmental science & technology.

[64]  C. Mirkin,et al.  Mechanistic study of photomediated triangular silver nanoprism growth. , 2008, Journal of the American Chemical Society.

[65]  J. Lakowicz,et al.  Silver particles enhance emission of fluorescent DNA oligomers. , 2003, BioTechniques.

[66]  Francesco Stellacci,et al.  Antibacterial activity of silver nanoparticles: A surface science insight , 2015 .

[67]  Luke P. Lee,et al.  Nanoplasmonic optical antennas for life sciences and medicine , 2018, Nature Reviews Materials.

[68]  R. Hurt,et al.  Chemical transformations of nanosilver in biological environments. , 2012, ACS nano.

[69]  Yulei Chang,et al.  Towards high quality triangular silver nanoprisms: improved synthesis, six-tip based hot spots and ultra-high local surface plasmon resonance sensitivity. , 2015, Nanoscale.

[70]  J. Turkevich,et al.  Colloidal gold. Part I , 1985 .

[71]  Frank Einar Kruis,et al.  Sintering and evaporation characteristics of gas-phase synthesis of size-selected PbS nanoparticles , 2000 .

[72]  Deirdre M. Ledwith,et al.  Optical Properties and Growth Aspects of Silver Nanoprisms Produced by a Highly Reproducible and Rapid Synthesis at Room Temperature , 2008 .

[73]  Yanming Liu,et al.  Enhanced chemiluminescence by Au-Ag core-shell nanoparticles: A general and practical biosensing platform for tumor marker detection , 2018, Journal of Luminescence.

[74]  R. G. Freeman,et al.  SERS as a Foundation for Nanoscale, Optically Detected Biological Labels , 2007 .

[75]  Jun Li,et al.  Shape Control of Silver Nanoparticles by Stepwise Citrate Reduction , 2009 .

[76]  Richard P Van Duyne,et al.  Creating, characterizing, and controlling chemistry with SERS hot spots. , 2013, Physical chemistry chemical physics : PCCP.

[77]  V. Sharma,et al.  Silver nanoparticles: green synthesis and their antimicrobial activities. , 2009, Advances in colloid and interface science.

[78]  Zhe-Sheng Chen,et al.  Silver nanoparticles: synthesis, properties, and therapeutic applications. , 2015, Drug discovery today.

[79]  Marco Lazzarino,et al.  Nanoscale chemical mapping using three-dimensional adiabatic compression of surface plasmon polaritons. , 2010, Nature Nanotechnology.

[80]  E Olsson,et al.  Silver-based crystalline nanoparticles, microbially fabricated. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[81]  Younan Xia,et al.  Right bipyramids of silver: a new shape derived from single twinned seeds. , 2006, Nano letters.

[82]  H. Bönnemann,et al.  Nanoscopic Metal Particles − Synthetic Methods and Potential Applications , 2001 .

[83]  Enzyme-catalyzed Ag Growth on Au Nanoparticle-assembled Structure for Highly Sensitive Colorimetric Immunoassay , 2018, Scientific Reports.

[84]  Dieter Braun,et al.  The toxic effect of silver ions and silver nanoparticles towards bacteria and human cells occurs in the same concentration range , 2012 .

[85]  Ramanathan Vaidyanathan,et al.  Antiangiogenic properties of silver nanoparticles. , 2009, Biomaterials.

[86]  Yu-Ming Chang,et al.  Large-Scale Hot Spot Engineering for Quantitative SERS at the Single-Molecule Scale. , 2015, Journal of the American Chemical Society.

[87]  Younan Xia,et al.  Synthesis and optical properties of silver nanobars and nanorice. , 2007, Nano letters.

[88]  Yong-Kweon Kim,et al.  Multifunctional silver-embedded magnetic nanoparticles as SERS nanoprobes and their applications. , 2010, Small.

[89]  I. Sondi,et al.  Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. , 2004, Journal of colloid and interface science.

[90]  R. Lennox,et al.  New insights into Brust-Schiffrin metal nanoparticle synthesis. , 2010, Journal of the American Chemical Society.

[91]  Joel N. Meyer,et al.  A systematic review of evidence for silver nanoparticle-induced mitochondrial toxicity , 2016 .

[92]  B. Nyström,et al.  Anti-cancerous effect of albumin coated silver nanoparticles on MDA-MB 231 human breast cancer cell line , 2017, Scientific Reports.

[93]  Janina Kneipp,et al.  In vivo molecular probing of cellular compartments with gold nanoparticles and nanoaggregates. , 2006, Nano letters.

[94]  Sang Hun Lee,et al.  Multifunctional self-assembled monolayers via microcontact printing and degas-driven flow guided patterning , 2018, Scientific Reports.

[95]  Aniket Gade,et al.  Fungus-mediated synthesis of silver nanoparticles and their activity against pathogenic fungi in combination with fluconazole. , 2009, Nanomedicine : nanotechnology, biology, and medicine.

[96]  Tai Hyun Park,et al.  Nanomaterial-Based Biosensor as an Emerging Tool for Biomedical Applications , 2011, Annals of Biomedical Engineering.

[97]  Mingli Chen,et al.  Core-shell-shell nanorods for controlled release of silver that can serve as a nanoheater for photothermal treatment on bacteria. , 2015, Acta biomaterialia.

[98]  R. L. Jones,et al.  Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. , 2008, The journal of physical chemistry. B.

[99]  Soumyo Mukherji,et al.  Size-controlled silver nanoparticles synthesized over the range 5–100 nm using the same protocol and their antibacterial efficacy , 2014 .

[100]  Preparation of plasmonic monolayer with Ag and Au nanoparticles for dye-sensitized solar cells , 2017 .

[101]  Alke Petri-Fink,et al.  Form Follows Function: Nanoparticle Shape and Its Implications for Nanomedicine. , 2017, Chemical reviews.

[102]  M. Natan,et al.  Glass-Coated, Analyte-Tagged Nanoparticles: A New Tagging System Based on Detection with Surface-Enhanced Raman Scattering , 2003 .

[103]  Seonho Cho,et al.  Green synthesis of gold and silver nanoparticles using gallic acid: catalytic activity and conversion yield toward the 4-nitrophenol reduction reaction , 2016, Journal of Nanoparticle Research.

[104]  Yi Yan Yang,et al.  Au-Ag core-shell nanoparticles for simultaneous bacterial imaging and synergistic antibacterial activity. , 2017, Nanomedicine : nanotechnology, biology, and medicine.

[105]  G. Thompson,et al.  Release of silver and copper nanoparticles from polyethylene nanocomposites and their penetration into Listeria monocytogenes. , 2014, Materials science & engineering. C, Materials for biological applications.

[106]  Younan Xia,et al.  Kinetically controlled overgrowth of Ag or Au on Pd nanocrystal seeds: from hybrid dimers to nonconcentric and concentric bimetallic nanocrystals. , 2012, Journal of the American Chemical Society.

[107]  Sulabha K. Kulkarni,et al.  Nitrate reductase-mediated synthesis of silver nanoparticles from AgNO3 , 2007, Biotechnology Letters.

[108]  Younan Xia,et al.  Gold nanocages: synthesis, properties, and applications. , 2008, Accounts of chemical research.

[109]  C. Whitchurch,et al.  Combination of Silver Nanoparticles and Curcumin Nanoparticles for Enhanced Anti-biofilm Activities. , 2016, Journal of agricultural and food chemistry.

[110]  Xuesi Chen,et al.  One-pot synthesis of polyacrylamide-gold nanocomposite , 2007 .

[111]  Tai Hyun Park,et al.  Real-time monitoring of odorant-induced cellular reactions using surface plasmon resonance. , 2009, Biosensors & bioelectronics.

[112]  Sureshbabu Ram Kumar Pandian,et al.  Enhanced silver nanoparticle synthesis by optimization of nitrate reductase activity. , 2010, Colloids and surfaces. B, Biointerfaces.

[113]  A. Ludwig,et al.  Antibacterial Efficacy of Sacrifical Anode Thin Films Combining Silver with Platinum Group Elements within a Bacteria‐Containing Human Plasma Clot , 2018 .

[114]  M. Hande,et al.  Anti-proliferative activity of silver nanoparticles , 2009, BMC Cell Biology.

[115]  Younan Xia,et al.  Polyol Synthesis of Silver Nanoparticles: Use of Chloride and Oxygen to Promote the Formation of Single-Crystal, Truncated Cubes and Tetrahedrons , 2004 .

[116]  Valeria Caprettini,et al.  Live Intracellular Biorthogonal Imaging by Surface Enhanced Raman Spectroscopy using Alkyne-Silver Nanoparticles Clusters , 2018, Scientific Reports.

[117]  Mathias Brust,et al.  Synthesis of thiol-derivatised gold nanoparticles in a two-phase liquid-liquid system , 1994 .

[118]  K. Kalishwaralal,et al.  Size-based cytotoxicity of silver nanoparticles in bovine retinal endothelial cells , 2012 .

[119]  Markus Niederberger,et al.  The fascinating world of nanoparticle research , 2013 .

[120]  P. Kamat,et al.  What Factors Control the Size and Shape of Silver Nanoparticles in the Citrate Ion Reduction Method , 2004 .

[121]  Chad A Mirkin,et al.  Colloidal gold and silver triangular nanoprisms. , 2009, Small.

[122]  Ying Wang,et al.  A novel aptasensor based on silver nanoparticle enhanced fluorescence. , 2012, Biosensors & bioelectronics.

[123]  Sang Hun Lee,et al.  Front-illuminated dye-sensitized solar cells with Ag nanoparticle-functionalized freestanding TiO 2 nanotube arrays , 2014 .

[124]  Van Son Vu,et al.  Optical nanoparticles: synthesis and biomedical application , 2015 .

[125]  Wei Wang,et al.  Cytotoxicity induced by engineered silver nanocrystallites is dependent on surface coatings and cell types. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[126]  C. Mirkin,et al.  Photoinduced Conversion of Silver Nanospheres to Nanoprisms , 2001, Science.

[127]  M. Stockman.  Nanoplasmonics: The physics behind the applications , 2011 .

[128]  Myeong Geun Cha,et al.  Multilayer Ag-Embedded Silica Nanostructure as a Surface-Enhanced Raman Scattering-Based Chemical Sensor with Dual-Function Internal Standards. , 2018, ACS applied materials & interfaces.

[129]  Pieter G. Kik,et al.  Single Particle Spectroscopy Study of Metal-Film-Induced Tuning of Silver Nanoparticle Plasmon Resonances† , 2010 .

[130]  Xiaohong Sun,et al.  Fabrication of Ag@SiO(2)@Y(2)O(3):Er nanostructures for bioimaging: tuning of the upconversion fluorescence with silver nanoparticles. , 2010, Journal of the American Chemical Society.

[131]  Chunlei Wang,et al.  Enhanced Raman scattering of graphene by silver nanoparticles with different densities and locations , 2017 .

[132]  Tae Han Kim,et al.  Ag and Ag─Au Introduced Silica‐coated Magnetic Beads , 2018 .

[133]  Luping Yu,et al.  Cooperative plasmonic effect of Ag and Au nanoparticles on enhancing performance of polymer solar cells. , 2013, Nano letters.

[134]  Kai Zhang,et al.  Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity. , 2015, ACS nano.

[135]  M. Saravanan,et al.  Green synthesis of silver nanoparticles using Rheum palmatum root extract and their antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa , 2017, Artificial cells, nanomedicine, and biotechnology.

[136]  Wei Zhou,et al.  A label-free biosensor based on silver nanoparticles array for clinical detection of serum p53 in head and neck squamous cell carcinoma , 2011, International journal of nanomedicine.

[137]  M. M. Oliveira,et al.  Influence of synthetic parameters on the size, structure, and stability of dodecanethiol-stabilized silver nanoparticles. , 2005, Journal of colloid and interface science.

[138]  Qingshan Shi,et al.  Antibacterial activity and mechanism of silver nanoparticles on Escherichia coli , 2009, Applied Microbiology and Biotechnology.

[139]  S. Kim,et al.  Antibacterial Activity of Silver-nanoparticles Against Staphylococcus aureus and Escherichia coli , 2011 .

[140]  R. V. Van Duyne,et al.  Probing the structure of single-molecule surface-enhanced Raman scattering hot spots. , 2008, Journal of the American Chemical Society.

[141]  C. D. Geddes,et al.  Distance Dependence of Metal-Enhanced Fluorescence , 2012, Plasmonics.

[142]  S. Gurunathan,et al.  Molecular Sciences , 2022 .