When and how to start prophylaxis in boys with severe hemophilia without inhibitors: communication from the SSC of the ISTH

K . F I SCHER ,*† P . W. COLL INS ,‡ M. C . OZELO,§¶ A . SR IVASTAVA ,k G. YOUNG**†† and V . S . BLANCHETTE‡‡§§ *Van Creveldkliniek, University Medical Center Utrecht; †Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; ‡Arthur Bloom Haemophilia Centre, School of Medicine, Cardiff University, Cardiff, UK; §INCT do Sangue Hemocentro Unicamp, University of Campinas; ¶Faculty of Medical Sciences Unicamp, University of Campinas, Campinas, Brazil; kDepartment of Haematology, Christian Medical College, Vellore, India; **Hemostasis and Thrombosis Center, Children’s Hospital; ††University of Southern California Keck School of Medicine, Los Angeles, CA, USA; ‡‡Pediatric Thrombosis and Hemostasis Program, Hospital for Sick Children, University of Toronto; and §§Department of Pediatrics, University of Toronto, Toronto, Canada