Psychological Benefits of Nonpharmacological Methods Aimed for Improving Balance in Parkinson's Disease: A Systematic Review

Parkinson's disease (PD) is a serious condition with a major negative impact on patient's physical and mental health. Postural instability is one of the cardinal difficulties reported by patients to deal with. Neuroanatomical, animal, and clinical studies on nonparkinsonian and parkinsonian subjects suggest an important correlation between the presence of balance dysfunction and multiple mood disorders, such as anxiety, depression, and apathy. Considering that balance dysfunction is a very common symptom in PD, we can presume that by its management we could positively influence patient's state of mind too. This review is an analysis of nonpharmacological methods shown to be effective and successful for improving balance in patients suffering from PD. Strategies such as general exercise, robotic assisted training, Tai Chi, Qi Gong, Yoga, dance (such as tango or ballet), box, virtual reality-based, or neurofeedback-based techniques and so forth can significantly improve the stability in these patients. Beside this physical outcome, many methods have also shown effect on quality of life, depression level, enjoyment, and motivation to continue in practicing the method independently. The purpose of this review is to provide information about practical and creative methods designed to improve balance in PD and highlight their positive impact on patient's psychology.

[1]  P. Stanzione,et al.  Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease. , 2007, Brain : a journal of neurology.

[2]  J. Cudeiro,et al.  Aquatic therapy versus conventional land-based therapy for Parkinson's disease: an open-label pilot study. , 2011, Archives of physical medicine and rehabilitation.

[3]  N. Paker,et al.  Effects of robotic treadmill training on functional mobility, walking capacity, motor symptoms and quality of life in ambulatory patients with Parkinson's disease: a preliminary prospective longitudinal study. , 2013, NeuroRehabilitation.

[4]  X. Caro,et al.  EEG Biofeedback Treatment Improves Certain Attention and Somatic Symptoms in Fibromyalgia: A Pilot Study , 2011, Applied psychophysiology and biofeedback.

[5]  G. Batson Feasibility of an Intensive Trial of Modern Dance for Adults with Parkinson Disease , 2010 .

[6]  M. Hely,et al.  The Sydney multicentre study of Parkinson’s disease: progression and mortality at 10 years , 1999, Journal of neurology, neurosurgery, and psychiatry.

[7]  R. Mattioli,et al.  Effects of treadmill-walking training with additional body load on quality of life in subjects with Parkinson's disease. , 2010, Revista brasileira de fisioterapia (Sao Carlos (Sao Paulo, Brazil)).

[8]  A. Bentivoglio,et al.  Replacement of dopaminergic medication with subthalamic nucleus stimulation in Parkinson's disease: Long‐term observation , 2009, Movement disorders : official journal of the Movement Disorder Society.

[9]  J F Thayer,et al.  Neurological bases for balance-anxiety links. , 2001, Journal of anxiety disorders.

[10]  Madeleine. E. Hackney,et al.  A Study on the Effects of Argentine Tango as a Form of Partnered Dance for those with Parkinson Disease and the Healthy Elderly , 2007 .

[11]  C. Maitland,et al.  The effects of a balance and strength training program on equilibrium in Parkinsonism: A preliminary study. , 2000, NeuroRehabilitation.

[12]  Jeffrey M. Hausdorff,et al.  Six weeks of intensive treadmill training improves gait and quality of life in patients with Parkinson's disease: a pilot study. , 2007, Archives of physical medicine and rehabilitation.

[13]  Wiebren Zijlstra,et al.  Audio-Biofeedback training for posture and balance in Patients with Parkinson's disease , 2011, Journal of NeuroEngineering and Rehabilitation.

[14]  M. Mak,et al.  Repetitive step training with preparatory signals improves stability limits in patients with Parkinson's disease. , 2012, Journal of rehabilitation medicine.

[15]  K. Fitzgerald,et al.  2.358 POSTURAL STABILITY IN PARKINSON'S DISEASE PATIENTS AFTER TAI CHI TRAINING: A RANDOMIZED CONTROLLED TRIAL , 2012 .

[16]  Mark V Albert,et al.  Wii Fit Balance Board Playing Improves Balance and Gait in Parkinson Disease , 2013, PM & R : the journal of injury, function, and rehabilitation.

[17]  S. Gill,et al.  Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson's disease , 2005, Neuroreport.

[18]  S. Fereshtehnejad,et al.  Tango for treatment of motor and non-motor manifestations in Parkinson's disease: a randomized control study. , 2015, Complementary therapies in medicine.

[19]  S. Hague,et al.  Neurodegenerative disorders: Parkinson’s disease and Huntington’s disease , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[20]  G. Reppa The Effects of a New Program (balance & reform) On Trait Anxiety and Self- esteem: a Pilot Study , 2013 .

[21]  G. Earhart,et al.  Effects of a short duration, high dose contact improvisation dance workshop on Parkinson disease: a pilot study. , 2010, Complementary therapies in medicine.

[22]  Aaas News,et al.  Book Reviews , 1893, Buffalo Medical and Surgical Journal.

[23]  Carey D. Balaban,et al.  Vestibular nucleus projections to the parabrachial nucleus in rabbits: implications for vestibular influences on the autonomic nervous system , 1996, Experimental Brain Research.

[24]  Miss A.O. Penney (b) , 1974, The New Yale Book of Quotations.

[25]  A. Bentivoglio,et al.  Motor and cognitive outcome in patients with Parkinson's disease 8 years after subthalamic implants. , 2010, Brain : a journal of neurology.

[26]  D. Aarsland,et al.  The association between motor subtypes and psychopathology in Parkinson's disease. , 2009, Parkinsonism & related disorders.

[27]  F. Grandas,et al.  Risk of Falls in Parkinson's Disease: A Cross-Sectional Study of 160 Patients , 2012, Parkinson's disease.

[28]  W. Marsden I and J , 2012 .

[29]  R. D. de Haan,et al.  Determinants of disability and quality of life in mild to moderate Parkinson disease , 2008, Neurology.

[30]  D. Charney,et al.  Toward an integrated neurobiology of panic disorder. , 1997, The Journal of clinical psychiatry.

[31]  Gammon M Earhart,et al.  Tai Chi improves balance and mobility in people with Parkinson disease. , 2008, Gait & posture.

[32]  Jean-Francois Esculier,et al.  Home-based balance training programme using Wii Fit with balance board for Parkinsons's disease: a pilot study. , 2012, Journal of rehabilitation medicine.

[33]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[34]  K. Dujardin,et al.  Symptomatology and markers of anxiety disorders in Parkinson's disease: A cross‐sectional study , 2011, Movement disorders : official journal of the Movement Disorder Society.

[35]  D. Menétrey,et al.  Neuropeptides and catecholamines in efferent projections of the nuclei of the solitary tract in the rat , 1990, The Journal of comparative neurology.

[36]  M. Fernández-Del-Olmo,et al.  Mechanisms involved in treadmill walking improvements in Parkinson's disease. , 2010, Gait & posture.

[37]  Chengqi He,et al.  Effects of Tai Chi on balance and fall prevention in Parkinson’s disease: a randomized controlled trial , 2014, Clinical rehabilitation.

[38]  Angelo Antonini,et al.  The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease , 2009, Movement disorders : official journal of the Movement Disorder Society.

[39]  D. Aarsland,et al.  The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson’s disease , 2009, Journal of Neurology, Neurosurgery, and Psychiatry.

[40]  G. Ebersbach,et al.  Whole body vibration versus conventional physiotherapy to improve balance and gait in Parkinson's disease. , 2008, Archives of physical medicine and rehabilitation.

[41]  J. Jeong,et al.  Tai Chi Exercise can Improve the Obstacle Negotiating Ability of People with Parkinson’s Disease: A Preliminary Study , 2014, Journal of physical therapy science.

[42]  N. Murphy,et al.  A controlled clinical trial investigating the effects of cycle ergometry training on exercise tolerance, balance and quality of life in patients with Parkinson’s disease , 2013, Disability and rehabilitation.

[43]  A. Schrag,et al.  Psychosis, apathy, depression and anxiety in Parkinson's disease , 2012, Neurobiology of Disease.

[44]  E. Siemers,et al.  Anxiety and motor performance in parkinson's disease , 1993, Movement disorders : official journal of the Movement Disorder Society.

[45]  Andreas Daffertshofer,et al.  Effects of augmented visual feedback during balance training in Parkinson's disease: a pilot randomized clinical trial. , 2014, Parkinsonism & related disorders.

[46]  Madeleine. E. Hackney,et al.  Short duration, intensive tango dancing for Parkinson disease: an uncontrolled pilot study. , 2009, Complementary therapies in medicine.

[47]  Y. Agid,et al.  Stimulation of the subthalamic nucleus in Parkinson’s disease: a 5 year follow up , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[48]  M. Fernández-Del-Olmo,et al.  The effects of treadmill or overground walking training program on gait in Parkinson's disease. , 2013, Gait & posture.

[49]  R. Moore,et al.  Efferent projections of the paraventricular thalamic nucleus in the rat , 1995, The Journal of comparative neurology.

[50]  Vittorio Sanguineti,et al.  A feasibility study on using kinect™ for the rehabilitation in persons with Parkinson's disease , 2013 .

[51]  A. Bauman Chapter 1 – Health benefits of physical activity for older adults – epidemiological approaches to the evidence , 2004 .

[52]  J. D. Porter,et al.  Connections between the vestibular nuclei and brain stem regions that mediate autonomic function in the rat. , 1997, Journal of vestibular research : equilibrium & orientation.

[53]  Madeleine. E. Hackney,et al.  Effects of Dance on Gait and Balance in Parkinson’s Disease: A Comparison of Partnered and Nonpartnered Dance Movement , 2010, Neurorehabilitation and neural repair.

[54]  W. H. Staples,et al.  Boxing Training for Patients With Parkinson Disease: A Case Series , 2011, Physical Therapy.

[55]  Meg E Morris,et al.  Determinants of health-related quality of life in Parkinson's disease: a systematic review. , 2011, Parkinsonism & related disorders.

[56]  A. Genç,et al.  The effect of supervised exercises on static and dynamic balance in Parkinson's disease patients. , 2012, NeuroRehabilitation.

[57]  B. Bloem,et al.  Balance problems with Parkinson's disease: are they anxiety-dependent? , 2011, Neuroscience.

[58]  Yvonne M Colgrove,et al.  A randomized controlled pilot study of the therapeutic effects of yoga in people with Parkinson's disease , 2015, International journal of yoga.

[59]  Wim E J Weber,et al.  Neuroanatomical correlates of apathy in Parkinson's disease: A magnetic resonance imaging study using voxel‐based morphometry , 2010, Movement disorders : official journal of the Movement Disorder Society.

[60]  Tatiana de Paula Oliveira,et al.  Effect of Nintendo Wii™-based motor and cognitive training on activities of daily living in patients with Parkinson's disease: a randomised clinical trial. , 2012, Physiotherapy.

[61]  J. Gallo,et al.  Systematic review of factors associated with depression and anxiety disorders among older adults with Parkinson's disease. , 2014, Parkinsonism & related disorders.

[62]  J. Black,et al.  Parkinson's disease complicated by anxiety. , 1987, Mayo Clinic proceedings.

[63]  I. Bodis-Wollner,et al.  Dance for PD: a preliminary investigation of effects on motor function and quality of life among persons with Parkinson’s disease (PD) , 2015, Journal of Neural Transmission.

[64]  J E Deutsch,et al.  Feasibility, safety and outcomes of playing Kinect Adventures!™ for people with Parkinson's disease: a pilot study. , 2014, Physiotherapy.

[65]  M. Jahanshahi,et al.  Quality of life in Parkinson's disease: The relative importance of the symptoms , 2008, Movement disorders : official journal of the Movement Disorder Society.

[66]  R. Maestri,et al.  Effectiveness of an intensive rehabilitation treatment on different Parkinson's disease subtypes. , 2013, NeuroRehabilitation.

[67]  K. Willett,et al.  Wii-habilitation: is there a role in trauma? , 2010, Injury.

[68]  Luca Fiorentini,et al.  Postural rehabilitation and Kinesio taping for axial postural disorders in Parkinson's disease. , 2014, Archives of physical medicine and rehabilitation.

[69]  N. Smania,et al.  Does robotic gait training improve balance in Parkinson's disease? A randomized controlled trial. , 2012, Parkinsonism & related disorders.

[70]  J. Wilczyński,et al.  Postural stability in Parkinson's disease patients. , 2017, Acta of bioengineering and biomechanics.

[71]  A. Schmid,et al.  Effect of a 12-week yoga intervention on fear of falling and balance in older adults: a pilot study. , 2010, Archives of physical medicine and rehabilitation.

[72]  M. Lanotte,et al.  Freezing and hypokinesia of gait induced by stimulation of the subthalamic region , 2007, Journal of the Neurological Sciences.

[73]  Joe R. Nocera,et al.  The effect of Tai Chi exercise on gait initiation and gait performance in persons with Parkinson's disease. , 2013, Parkinsonism & related disorders.

[74]  Heidi Sveistrup,et al.  Functional Balance and Dual-Task Reaction Times in Older Adults Are Improved by Virtual Reality and Biofeedback Training , 2007, Cyberpsychology Behav. Soc. Netw..

[75]  Lynn Rochester,et al.  Mild depressive symptoms are associated with gait impairment in early Parkinson's disease , 2013, Movement disorders : official journal of the Movement Disorder Society.

[76]  Colin G. Ellard,et al.  Does Anxiety Cause Freezing of Gait in Parkinson's Disease? , 2014, PloS one.

[77]  K. Sethi,et al.  Nintendo Wii rehabilitation ("Wii-hab") provides benefits in Parkinson's disease. , 2013, Parkinsonism & related disorders.

[78]  A. Damasio,et al.  Emotion in the perspective of an integrated nervous system 1 Published on the World Wide Web on 27 January 1998. 1 , 1998, Brain Research Reviews.

[79]  S. Rehncrona,et al.  The effects of high frequency subthalamic stimulation on balance performance and fear of falling in patients with Parkinson's disease , 2009, Journal of NeuroEngineering and Rehabilitation.

[80]  Hyun-Seung Song,et al.  Effect of virtual reality dance exercise on the balance, activities of daily living, and depressive disorder status of Parkinson’s disease patients , 2015, Journal of physical therapy science.

[81]  T. Sathyaprabha,et al.  Effect of partial weight-supported treadmill gait training on balance in patients with Parkinson disease. , 2011, PM & R : the journal of injury, function, and rehabilitation.

[82]  J. Obeso,et al.  Functional organization of the basal ganglia: Therapeutic implications for Parkinson's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.

[83]  Tung-Wu Lu,et al.  Effects of Virtual Reality–Augmented Balance Training on Sensory Organization and Attentional Demand for Postural Control in People With Parkinson Disease: A Randomized Controlled Trial , 2011, Physical Therapy.

[84]  E. Bézard,et al.  Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms , 2009, The Lancet Neurology.

[85]  S. Rehncrona,et al.  Multicenter study on deep brain stimulation in Parkinson's disease: An independent assessment of reported adverse events at 4 years , 2008, Movement disorders : official journal of the Movement Disorder Society.

[86]  M. Zigmond,et al.  Can the brain be protected through exercise? Lessons from an animal model of parkinsonism☆ , 2003, Experimental Neurology.

[87]  A Schnitzler,et al.  Review: Deep brain stimulation in Parkinson’s disease , 2009, Therapeutic advances in neurological disorders.

[88]  S. Thomas,et al.  The health benefits of yoga and exercise: a review of comparison studies. , 2010, Journal of alternative and complementary medicine.

[89]  Gammon M Earhart,et al.  Barriers to Exercise in People With Parkinson Disease , 2013, Physical Therapy.

[90]  Claire Ballinger,et al.  A randomised controlled trial of a home based exercise programme to reduce the risk of falling among people with Parkinson’s disease , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[91]  P. Moberg,et al.  Falling risk factors in Parkinson's disease. , 2005, NeuroRehabilitation.

[92]  Anna Kamrowska,et al.  [Depression in Parkinson's disease]. , 2009, Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.

[93]  D. Basta,et al.  Vibrotactile neurofeedback balance training in patients with Parkinson's disease: reducing the number of falls. , 2013, Gait & posture.

[94]  J. Friedman Parkinson's disease psychosis 2010: a review article. , 2010, Parkinsonism & related disorders.

[95]  A M Bronstein,et al.  Combining physical training with transcranial direct current stimulation to improve gait in Parkinson’s disease: a pilot randomized controlled study , 2014, Clinical rehabilitation.

[96]  M. Mintz,et al.  Balance dysfunction in childhood anxiety: findings and theoretical approach , 2003, Journal of anxiety disorders.

[97]  H. Dinse,et al.  Frontiers in Aging Neuroscience Aging Neuroscience , 2022 .

[98]  Nicola Smania,et al.  Robot-Assisted Gait Training in Patients With Parkinson Disease , 2012, Neurorehabilitation and neural repair.

[99]  A. Bonnet,et al.  Nonmotor Symptoms in Parkinson's Disease in 2012: Relevant Clinical Aspects , 2012, Parkinson's disease.

[100]  P. Robert,et al.  Imaging correlates of apathy and depression in Parkinson's disease , 2011, Journal of the Neurological Sciences.

[101]  S. Loftus Qi Gong to Improve Postural Stability (QTIPS) for Parkinson Fall Prevention: A Neuroplasticity Approach , 2014 .

[102]  Marten Munneke,et al.  Effects of stereotactic neurosurgery on postural instability and gait in Parkinson's disease , 2004, Movement disorders : official journal of the Movement Disorder Society.

[103]  M. Sohrabi,et al.  Neurofeedback and physical balance in Parkinson's patients. , 2014, Gait & posture.

[104]  D. Aarsland,et al.  Prevalence and clinical correlates of apathy in Parkinson's disease: a community-based study. , 2009, Parkinsonism & related disorders.

[105]  Marjan Jahanshahi,et al.  What contributes to quality of life in patients with Parkinson's disease? , 2000, Journal of neurology, neurosurgery, and psychiatry.

[106]  S. Rehncrona,et al.  Deep‐brain stimulation in the subthalamic nuclei improves balance performance in patients with Parkinson's disease, when tested without anti‐parkinsonian medication , 2005, Acta neurologica Scandinavica.

[107]  Madeleine. E. Hackney,et al.  Health-related quality of life and alternative forms of exercise in Parkinson disease. , 2009, Parkinsonism & related disorders.

[108]  A. Teixeira,et al.  Impact of changes in balance and walking capacity on the quality of life in patients with Parkinson's disease. , 2012, Arquivos de neuro-psiquiatria.

[109]  P. Kluding,et al.  Multidimensional exercise for people with Parkinson's disease: A case report , 2006, Physiotherapy theory and practice.

[110]  L. Panton,et al.  The effects of loading and unloading treadmill walking on balance, gait, fall risk, and daily function in Parkinsonism. , 2005, NeuroRehabilitation.

[111]  D. Bowers,et al.  Measurement of patient-centered outcomes in Parkinson's disease: what do patients really want from their treatment? , 2011, Parkinsonism & related disorders.

[112]  A Deutch,et al.  A functional neuroanatomy of anxiety and fear: implications for the pathophysiology and treatment of anxiety disorders. , 1996, Critical reviews in neurobiology.

[113]  A. Zwinderman,et al.  Prospective assessment of falls in Parkinson's disease , 2001, Journal of Neurology.

[114]  A. Brice,et al.  Parkinson's disease: from monogenic forms to genetic susceptibility factors. , 2009, Human molecular genetics.

[115]  Gammon M Earhart,et al.  Effects of dance on movement control in Parkinson's disease: a comparison of Argentine tango and American ballroom. , 2009, Journal of rehabilitation medicine.

[116]  L. Defebvre,et al.  Apathy may herald cognitive decline and dementia in Parkinson's disease , 2009, Movement disorders : official journal of the Movement Disorder Society.

[117]  G. Moriello,et al.  Incorporating yoga into an intense physical therapy program in someone with Parkinson's disease: a case report. , 2013, Journal of bodywork and movement therapies.

[118]  M. Morris,et al.  A randomized controlled trial of movement strategies compared with exercise for people with Parkinson's disease , 2009, Movement disorders : official journal of the Movement Disorder Society.

[119]  Margaret Schenkman,et al.  Exercise to Improve Spinal Flexibility and Function for People with Parkinson's Disease: A Randomized, Controlled Trial , 1998, Journal of the American Geriatrics Society.

[120]  H. Miyaguchi,et al.  Effects of dance on motor functions, cognitive functions, and mental symptoms of Parkinson's disease: a quasi-randomized pilot trial. , 2015, Complementary therapies in medicine.

[121]  P. Silburn,et al.  Anxiety disorders in Parkinson's disease: Prevalence and risk factors , 2010, Movement disorders : official journal of the Movement Disorder Society.

[122]  E. Tolosa,et al.  Cognitive dysfunction and dementia in Parkinson disease , 2007, Movement disorders : official journal of the Movement Disorder Society.

[123]  P. Rabins,et al.  Prevalence of anxiety disorders and anxiety subtypes in patients with Parkinson's disease , 2009, Movement disorders : official journal of the Movement Disorder Society.

[124]  F. Stella,et al.  Exercise programs improve mobility and balance in people with Parkinson's disease. , 2009, Parkinsonism & related disorders.

[125]  M. Gelabert-González,et al.  [Deep brain stimulation in Parkinson's disease]. , 2013, Revista de neurologia.

[126]  E. Tolosa,et al.  The Onset of Nonmotor Symptoms in Parkinson's disease (The ONSET PD Study) , 2015, Movement disorders : official journal of the Movement Disorder Society.

[127]  R. Stephenson A and V , 1962, The British journal of ophthalmology.

[128]  A. Ashburn,et al.  Effect of a yoga programme on an individual with Parkinson's disease: a single-subject design , 2011, Disability and rehabilitation.

[129]  Joe R. Nocera,et al.  Effects of home-based exercise on postural control and sensory organization in individuals with Parkinson disease. , 2009, Parkinsonism & related disorders.

[130]  A. Stiggelbout,et al.  A comprehensive model of health-related quality of life in Parkinson’s disease , 2008, Journal of Neurology.

[131]  The effects of deep brain stimulation and levodopa on postural sway in subjects with Parkinson's disease , 2002, Journal of neurology, neurosurgery, and psychiatry.

[132]  M. Hepp-Reymond,et al.  Impact of a Weekly Dance Class on the Functional Mobility and on the Quality of Life of Individuals with Parkinson’s Disease , 2011, Front. Ag. Neurosci..

[133]  C. Hass,et al.  Correlations of apathy and depression with postural instability in Parkinson disease , 2014, Journal of the Neurological Sciences.

[134]  A. Ståhle,et al.  Is highly challenging and progressive balance training feasible in older adults with Parkinson's disease? , 2014, Archives of physical medicine and rehabilitation.

[135]  Matti Mintz,et al.  Balance deficit enhances anxiety and balance training decreases anxiety in vestibular mutant mice , 2015, Behavioural Brain Research.

[136]  M. Morris,et al.  Optimizing Exercise and Physical Activity in Older People , 2004 .

[137]  J. A. Ricardo,et al.  Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat , 1978, Brain Research.

[138]  J. Jankovic Parkinson’s disease: clinical features and diagnosis , 2008, Journal of Neurology, Neurosurgery, and Psychiatry.

[139]  D. Maraganore,et al.  Fracture risk after the diagnosis of Parkinson's disease: Influence of concomitant dementia , 2006, Movement disorders : official journal of the Movement Disorder Society.

[140]  M. Mintz,et al.  Balance treatment ameliorates anxiety and increases self-esteem in children with comorbid anxiety and balance disorder. , 2009, Research in developmental disabilities.

[141]  Mehrsa Faridnia,et al.  The effect of neurofeedback training on the anxiety of elite female swimmers , 2012 .

[142]  H. Erdem,et al.  The effects of incremental speed-dependent treadmill training on postural instability and fear of falling in Parkinson's disease , 2007, Clinical rehabilitation.

[143]  A. Bronstein,et al.  Using vibrotactile feedback of instability to trigger a forward compensatory stepping response , 2007, Journal of Neurology.

[144]  E. Workman,et al.  Psychosis , 2010, BMJ : British Medical Journal.

[145]  C. Maitland,et al.  The effects of balance training and high-intensity resistance training on persons with idiopathic Parkinson's disease. , 2003, Archives of physical medicine and rehabilitation.

[146]  J. Raub,et al.  Psychophysiologic effects of Hatha Yoga on musculoskeletal and cardiopulmonary function: a literature review. , 2002, Journal of alternative and complementary medicine.

[147]  A. Benabid,et al.  Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease. , 2003, The New England journal of medicine.

[148]  V. Haroutunian,et al.  The neuropathological basis for depression in Parkinson's disease. , 2009, Parkinsonism & related disorders.

[149]  J. Gerber,et al.  High intensity eccentric resistance training decreases bradykinesia and improves Quality Of Life in persons with Parkinson's disease: a preliminary study. , 2009, Parkinsonism & related disorders.

[150]  David E Vaillancourt,et al.  A two‐year randomized controlled trial of progressive resistance exercise for Parkinson's disease , 2013, Movement disorders : official journal of the Movement Disorder Society.

[151]  W. Tsang Tai Chi training is effective in reducing balance impairments and falls in patients with Parkinson's disease. , 2013, Journal of physiotherapy.

[152]  Joe R. Nocera,et al.  Timed up and go, cognitive, and quality-of-life correlates in Parkinson's disease. , 2014, Archives of physical medicine and rehabilitation.